Gene Pathway Pathway source Gene number Edge number
UBB Activated NOTCH1 Transmits Signal to the Nucleus reactome 30 195
UBB Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon reactome 18 122
UBB Activation of NF-kappaB in B cells reactome 66 1552
UBB Amyloid fiber formation reactome 99 1690
UBB Antigen processing: Ubiquitination & Proteasome degradation reactome 260 9688
UBB APC-Cdc20 mediated degradation of Nek2A reactome 25 301
UBB APC/C:Cdc20 mediated degradation of Cyclin B reactome 23 254
UBB APC/C:Cdc20 mediated degradation of Securin reactome 66 2102
UBB APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 reactome 71 2321
UBB Assembly Of The HIV Virion reactome 5 10
UBB Association of licensing factors with the pre-replicative complex reactome 15 58
UBB Asymmetric localization of PCP proteins reactome 63 1276
UBB Attenuation phase reactome 28 222
UBB AUF1 (hnRNP D0) binds and destabilizes mRNA reactome 54 1209
UBB Autodegradation of Cdh1 by Cdh1:APC/C reactome 62 1892
UBB Autodegradation of the E3 ubiquitin ligase COP1 reactome 51 1160
UBB Budding and maturation of HIV virion reactome 25 300
UBB Cdc20:Phospho-APC/C mediated degradation of Cyclin A reactome 71 2480
UBB CDK-mediated phosphorylation and removal of Cdc6 reactome 50 1181
UBB CDT1 association with the CDC6:ORC:origin complex reactome 58 1191
UBB Circadian Clock reactome 49 389
UBB CLEC7A (Dectin-1) signaling reactome 78 1727
UBB Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants reactome 19 141
UBB Constitutive Signaling by NOTCH1 HD Domain Mutants reactome 15 90
UBB Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants reactome 57 500
UBB Constitutive Signaling by NOTCH1 PEST Domain Mutants reactome 57 500
UBB Cyclin D associated events in G1 reactome 38 366
UBB Deactivation of the beta-catenin transactivating complex reactome 42 236
UBB Dectin-1 mediated noncanonical NF-kB signaling reactome 61 1526
UBB Degradation of AXIN reactome 54 1370
UBB Degradation of beta-catenin by the destruction complex reactome 67 2178
UBB Degradation of DVL reactome 56 1335
UBB Degradation of GLI1 by the proteasome reactome 59 1494
UBB Degradation of GLI2 by the proteasome reactome 59 1505
UBB DNA Damage Recognition in GG-NER reactome 38 547
UBB Downregulation of ERBB2:ERBB3 signaling reactome 13 59
UBB Downregulation of ERBB4 signaling reactome 8 26
UBB Downregulation of SMAD2/3:SMAD4 transcriptional activity reactome 23 145
UBB Downregulation of TGF-beta receptor signaling reactome 26 168
UBB Downstream TCR signaling reactome 101 1991
UBB Dual Incision in GG-NER reactome 39 736
UBB Dual incision in TC-NER reactome 63 1948
UBB EGFR downregulation reactome 27 255
UBB EGFR1 netpath 475 10010
UBB Endosomal Sorting Complex Required For Transport (ESCRT) reactome 28 285
UBB ER-Phagosome pathway reactome 65 1264
UBB Fanconi Anemia Pathway reactome 39 627
UBB FCERI mediated NF-kB activation reactome 88 1785
UBB Formation of Incision Complex in GG-NER reactome 43 698
UBB Formation of TC-NER Pre-Incision Complex reactome 53 1056
UBB G2/M Checkpoints reactome 50 1193
UBB Gap-filling DNA repair synthesis and ligation in GG-NER reactome 23 246
UBB Gap-filling DNA repair synthesis and ligation in TC-NER reactome 62 1884
UBB GLI3 is processed to GLI3R by the proteasome reactome 59 1548
UBB Glycogen synthesis reactome 15 43
UBB HDR through Homologous Recombination (HRR) reactome 46 1019
UBB Hedgehog on state reactome 72 1642
UBB Hedgehog ligand biogenesis reactome 59 1198
UBB Hh mutants that dont undergo autocatalytic processing are degraded by ERAD reactome 55 1173
UBB HSF1-dependent transactivation reactome 34 190
UBB HSF1 activation reactome 31 235
UBB IKK complex recruitment mediated by RIP1 reactome 24 234
UBB IRAK2 mediated activation of TAK1 complex reactome 10 32
UBB IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation reactome 10 32
UBB ISG15 antiviral mechanism reactome 73 887
UBB MAP3K8 (TPL2)-dependent MAPK1/3 activation reactome 16 79
UBB MAPK6/MAPK4 signaling reactome 90 1485
UBB Membrane binding and targetting of GAG proteins reactome 11 45
UBB Myoclonic epilepsy of Lafora reactome 10 21
UBB Negative regulation of FGFR1 signaling reactome 26 303
UBB Negative regulation of FGFR2 signaling reactome 27 343
UBB Negative regulation of FGFR3 signaling reactome 22 219
UBB Negative regulation of FGFR4 signaling reactome 24 268
UBB Negative regulation of MAPK pathway reactome 38 287
UBB Negative regulators of RIG-I/MDA5 signaling reactome 34 215
UBB NF-kB is activated and signals survival reactome 13 61
UBB NIK-->noncanonical NF-kB signaling reactome 58 1471
UBB NOTCH1 Intracellular Domain Regulates Transcription reactome 47 463
UBB NOTCH2 Activation and Transmission of Signal to the Nucleus reactome 21 107
UBB NRIF signals cell death from the nucleus reactome 15 62
UBB Oncogene Induced Senescence reactome 30 146
UBB Orc1 removal from chromatin reactome 70 1618
UBB Oxidative Stress Induced Senescence reactome 120 3580
UBB Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha reactome 18 112
UBB p75NTR recruits signalling complexes reactome 13 53
UBB Pink/Parkin Mediated Mitophagy reactome 22 113
UBB Processing of DNA double-strand break ends reactome 98 2697
UBB PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 reactome 9 16
UBB Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor reactome 14 81
UBB Recognition of DNA damage by PCNA-containing replication complex reactome 28 338
UBB Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks reactome 75 2122
UBB Regulation of activated PAK-2p34 by proteasome mediated degradation reactome 49 1133
UBB Regulation of FZD by ubiquitination reactome 21 80
UBB Regulation of HSF1-mediated heat shock response reactome 82 1421
UBB Regulation of innate immune responses to cytosolic DNA reactome 14 43
UBB Regulation of PLK1 Activity at G2/M Transition reactome 87 2819
UBB Regulation of RAS by GAPs reactome 67 1453
UBB Regulation of TNFR1 signaling reactome 31 297
UBB Regulation of TP53 Activity through Methylation reactome 19 77
UBB Regulation of TP53 Activity through Phosphorylation reactome 89 1144
UBB Regulation of TP53 Degradation reactome 35 257
UBB SCF-beta-TrCP mediated degradation of Emi1 reactome 54 1387
UBB SCF(Skp2)-mediated degradation of p27/p21 reactome 59 1486
UBB Senescence-Associated Secretory Phenotype (SASP) reactome 108 2712
UBB Separation of Sister Chromatids reactome 163 7519
UBB Signaling by ERBB2 reactome 25 198
UBB SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription reactome 32 197
UBB Spry regulation of FGF signaling reactome 16 90
UBB Stabilization of p53 reactome 9 35
UBB Stimuli-sensing channels reactome 77 397
UBB TCF dependent signaling in response to WNT reactome 31 189
UBB Termination of translesion DNA synthesis reactome 30 338
UBB TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) reactome 16 116
UBB The role of GTSE1 in G2/M progression after G2 checkpoint reactome 59 1330
UBB TRAF6 Mediated Induction of proinflammatory cytokines reactome 5 10
UBB TRAF6 mediated induction of TAK1 complex reactome 16 101
UBB Transcription-Coupled Nucleotide Excision Repair (TC-NER) reactome 44 946
UBB Translesion Synthesis by POLH reactome 19 158
UBB Translesion synthesis by POLI reactome 17 136
UBB Translesion synthesis by POLK reactome 17 136
UBB Translesion synthesis by REV1 reactome 16 120
UBB Ubiquitin-dependent degradation of Cyclin D1 reactome 50 1137
UBB Ubiquitin Mediated Degradation of Phosphorylated Cdc25A reactome 52 1146
UBB Vif-mediated degradation of APOBEC3G reactome 53 1334
UBB Vpu mediated degradation of CD4 reactome 51 1231
UBB Parkinsons disease kegg 130 1329