TcoF overview
TcoF: CHEK2
GeneID: 10370
Name: Serine/threonine-protein kinase Chk2
Ensembl: ENSG00000183765
Species: Human
Class: class HC
Family: Others
Disease: 50
Go term: 45
Pathway: 20
Hallmark: 4
Super Enhancer:

chr22:29104022-29148727

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Enhancer:

chr22:29106050-29107890 chr22:29169210-29169710 chr22:29195140-29196290 chr22:29440880-29442700 chr22:29193190-29195040 chr22:29117620-29119300 chr22:29151440-29153060 chr22:29040490-29042100 chr22:29153740-29155020 chr22:29217970-29218300 chr22:29179630-29182070 chr22:29192180-29193060 chr22:29169770-29172010 chr22:29155350-29157690 chr22:29211340-29212070 chr22:29055260-29055980 chr22:29131920-29133040 chr22:29058160-29059480 chr22:29123810-29125600 chr22:29125860-29126400 chr22:29427140-29427370 chr22:29536360-29537930 chr22:28791080-28793500 chr22:29108010-29109740 chr22:29313470-29315520 chr22:29316430-29317800 chr22:29318450-29320700 chr22:29372100-29372570 chr22:29372940-29374670 chr22:29439420-29440760 chr22:29469220-29471660 chr22:29476030-29476880 chr22:29478280-29478880 chr22:29479840-29480450 chr22:29490410-29490540 chr22:29524900-29526440 chr22:29425250-29427070 chr22:29490860-29491990 chr22:28724900-28726740 chr22:28942880-28944710 chr22:29016220-29016890 chr22:29375710-29376640 chr22:29287130-29288970 chr22:29290310-29291390 chr22:29503710-29504660 chr22:29043640-29045530 chr22:29129320-29130230 chr22:29191720-29192030 chr22:29212740-29213460 chr22:29216980-29217700 chr22:29338020-29340450 chr22:29343950-29345130 chr22:29345440-29347300 chr22:29351140-29353350 chr22:29354360-29354990 chr22:29355050-29355350 chr22:29355670-29355820 chr22:29360610-29361180 chr22:29377680-29378400 chr22:29381870-29383060 chr22:29399690-29402060 chr22:29414290-29415840 chr22:29417750-29418790 chr22:29419240-29419920 chr22:29515530-29517340 chr22:29703180-29704040 chr22:29704730-29706420 chr22:29706540-29706620 chr22:29706720-29706810 chr22:29706990-29707450 chr22:29709980-29711010 chr22:29744450-29745200 chr22:29755950-29756090 chr22:29756320-29758120 chr22:29772200-29774460 chr22:29865440-29866960 chr22:29948440-29949430 chr22:29970780-29971680 chr22:29975560-29976970 chr22:30012880-30015120 chr22:30016520-30018780 chr22:30018860-30020330 chr22:30100100-30102090 chr22:30105860-30108120 chr22:29116410-29117180 chr22:30047380-30047760 chr22:29505050-29506940 chr22:29492140-29494220 chr22:29545340-29546560 chr22:28576790-28578810 chr22:28583360-28585270 chr22:28604570-28605710 chr22:28643140-28644970 chr22:28695310-28696330 chr22:28805670-28807910 chr22:28822240-28823980 chr22:28844510-28845350 chr22:28955160-28957230 chr22:29051500-29052890 chr22:29326280-29327340 chr22:29334160-29336080 chr22:29591120-29592430 chr22:28523740-28526180 chr22:28916920-28919250 chr22:29101560-29103760 chr22:29110020-29110460 chr22:29066200-29066640 chr22:29147270-29149440

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Promoter:

chr22:29083731-29138410

False
 ChIP-seq based regulatory details of CHEK2
select * from encode where Experiment_target='CHEK2'
Sample ID Experiment target Biosample type Biosample term name GSM ID Tissue type Source
 Downstream target genes of CHEK2
 Protein-protein interaction of CHEK2
OFFICIAL_SYMBOL_A OFFICIAL_SYMBOL_B EXPERIMENTAL_SYSTEM PUBMED_ID ORGANISM_A_ID ORGANISM_B_ID SOURCE
CHEK2 BRCA1 Reconstituted Complex 10724175 9606 9606 BIOGRID
CHEK2 BRCA1 Affinity Capture-Western 10724175 9606 9606 BIOGRID
CHEK2 MSH2 Reconstituted Complex 12447371 9606 9606 BIOGRID
CHEK2 MSH2 Affinity Capture-Western 12447371 9606 9606 BIOGRID
CHEK2 PLK3 Affinity Capture-Western 12242661 9606 9606 BIOGRID
CHEK2 PLK1 Affinity Capture-Western 12493754 9606 9606 BIOGRID
CHEK2 BRCA2 Affinity Capture-Western 17525332 9606 9606 BIOGRID
CHEK2 RAD50 Affinity Capture-Western 17525332 9606 9606 BIOGRID
CHEK2 TP53BP1 Affinity Capture-Western 17525332 9606 9606 BIOGRID
CHEK2 GINS2 Affinity Capture-Western 17525332 9606 9606 BIOGRID
CHEK2 MUS81 Reconstituted Complex 11741546 9606 9606 BIOGRID
CHEK2 BRCA1 Biochemical Activity 18804494 9606 9606 BIOGRID
CHEK2 CDC25A Biochemical Activity 18480045 9606 9606 BIOGRID
CHEK2 MDM2 Biochemical Activity 16943424 9606 9606 BIOGRID
CHEK2 MDM4 Biochemical Activity 16163388 9606 9606 BIOGRID
CHEK2 FOXM1 Biochemical Activity 17101782 9606 9606 BIOGRID
CHEK2 CDC25C Biochemical Activity 16705183 9606 9606 BIOGRID
CHEK2 REV3L Biochemical Activity 18622427 9606 9606 BIOGRID
CHEK2 TP53 Affinity Capture-Western 12810724 9606 9606 BIOGRID
CHEK2 CDC25A Biochemical Activity 12759351 9606 9606 BIOGRID
CHEK2 AATF Affinity Capture-Western 17157788 9606 9606 BIOGRID
CHEK2 TP53 Biochemical Activity 10673501 9606 9606 BIOGRID
CHEK2 CHEK2 Affinity Capture-Western 11901158 9606 9606 BIOGRID
CHEK2 CHEK2 Reconstituted Complex 11901158 9606 9606 BIOGRID
CHEK2 CHEK2 Biochemical Activity 11901158 9606 9606 BIOGRID
CHEK2 CHEK2 Affinity Capture-Western 12024051 9606 9606 BIOGRID
CHEK2 CHEK2 Reconstituted Complex 12024051 9606 9606 BIOGRID
CHEK2 CHEK2 Biochemical Activity 12024051 9606 9606 BIOGRID
CHEK2 CDC25C Biochemical Activity 12024051 9606 9606 BIOGRID
CHEK2 PPP2R2B Two-hybrid 15380617 9606 9606 BIOGRID
CHEK2 PPP2R5A Two-hybrid 15380617 9606 9606 BIOGRID
CHEK2 PPP2R5D Two-hybrid 15380617 9606 9606 BIOGRID
CHEK2 PPP2R5C Two-hybrid 15380617 9606 9606 BIOGRID
CHEK2 PPP2R5E Two-hybrid 15380617 9606 9606 BIOGRID
CHEK2 PPP2R5E Reconstituted Complex 15380617 9606 9606 BIOGRID
CHEK2 PPP2R5A Reconstituted Complex 15380617 9606 9606 BIOGRID
CHEK2 PPP2R5D Reconstituted Complex 15380617 9606 9606 BIOGRID
CHEK2 PPP2R5C Reconstituted Complex 15380617 9606 9606 BIOGRID
CHEK2 PPP2R5B Reconstituted Complex 15380617 9606 9606 BIOGRID
CHEK2 PPP2R5C Affinity Capture-Western 15380617 9606 9606 BIOGRID
CHEK2 PPP2R1A Affinity Capture-Western 15380617 9606 9606 BIOGRID
CHEK2 PPP2CA Affinity Capture-Western 15380617 9606 9606 BIOGRID
CHEK2 PPP2R5C Biochemical Activity 15380617 9606 9606 BIOGRID
CHEK2 TRIM28 Affinity Capture-Western 22496453 9606 9606 BIOGRID
CHEK2 PSME3 Affinity Capture-Western 19556897 9606 9606 BIOGRID
CHEK2 LATS2 Biochemical Activity 21118956 9606 9606 BIOGRID
CHEK2 MDM2 Affinity Capture-Western 19176998 9606 9606 BIOGRID
CHEK2 KAT2B Affinity Capture-Western 19176998 9606 9606 BIOGRID
CHEK2 PML Biochemical Activity 12402044 9606 9606 BIOGRID
CHEK2 CDC25C Biochemical Activity 12402044 9606 9606 BIOGRID
CHEK2 PML Affinity Capture-Western 12402044 9606 9606 BIOGRID
CHEK2 BRCA2 Protein-peptide 14623252 9606 9606 BIOGRID
CHEK2 BRCA1 Biochemical Activity 12438214 9606 9606 BIOGRID
CHEK2 MDM2 Reconstituted Complex 15862297 9606 9606 BIOGRID
CHEK2 TP53 Biochemical Activity 15862297 9606 9606 BIOGRID
CHEK2 MDM2 Biochemical Activity 15862297 9606 9606 BIOGRID
CHEK2 UBR5 Affinity Capture-MS 17074762 9606 9606 BIOGRID
CHEK2 UBR5 Affinity Capture-Western 17074762 9606 9606 BIOGRID
CHEK2 TP53 Biochemical Activity 10710310 9606 9606 BIOGRID
CHEK2 RB1 Biochemical Activity 17380128 9606 9606 BIOGRID
CHEK2 BRCA1 Biochemical Activity 17380128 9606 9606 BIOGRID
CHEK2 RB1 Reconstituted Complex 17380128 9606 9606 BIOGRID
CHEK2 RB1 Affinity Capture-Western 17380128 9606 9606 BIOGRID
CHEK2 KPNA2 Two-hybrid 12909615 9606 9606 BIOGRID
CHEK2 KPNA2 Reconstituted Complex 12909615 9606 9606 BIOGRID
CHEK2 CHEK2 Biochemical Activity 12909615 9606 9606 BIOGRID
CHEK2 CDC25C Biochemical Activity 12909615 9606 9606 BIOGRID
CHEK2 APP Reconstituted Complex 21832049 9606 9606 BIOGRID
CHEK2 STRAP Biochemical Activity 18833288 9606 9606 BIOGRID
CHEK2 TP53 Biochemical Activity 18833288 9606 9606 BIOGRID
CHEK2 CHEK2 Biochemical Activity 12676583 9606 9606 BIOGRID
CHEK2 CDC25A Biochemical Activity 12676583 9606 9606 BIOGRID
CHEK2 CUL4A Affinity Capture-Western 23109433 9606 9606 BIOGRID
CHEK2 CUL1 Affinity Capture-Western 23109433 9606 9606 BIOGRID
CHEK2 CDC25C Biochemical Activity 11438675 9606 9606 BIOGRID
CHEK2 CHEK2 Biochemical Activity 11438675 9606 9606 BIOGRID
CHEK2 CDC25C Biochemical Activity 10744722 9606 9606 BIOGRID
CHEK2 ELAVL1 Two-hybrid 17317627 9606 9606 BIOGRID
CHEK2 ELAVL1 Biochemical Activity 17317627 9606 9606 BIOGRID
CHEK2 CDC25A Biochemical Activity 11298456 9606 9606 BIOGRID
CHEK2 CDC25A Reconstituted Complex 11298456 9606 9606 BIOGRID
CHEK2 RCHY1 Affinity Capture-Western 23449389 9606 9606 BIOGRID
CHEK2 VHL Biochemical Activity 22071692 9606 9606 BIOGRID
CHEK2 CHEK2 Biochemical Activity 16794575 9606 9606 BIOGRID
CHEK2 CHEK2 Co-crystal Structure 16794575 9606 9606 BIOGRID
CHEK2 NR4A1 Two-hybrid 21988832 9606 9606 BIOGRID
CHEK2 POLR2L Two-hybrid 21988832 9606 9606 BIOGRID
CHEK2 SIRT1 Affinity Capture-Western 25361978 9606 9606 BIOGRID
CHEK2 CCAR2 Affinity Capture-Western 25361978 9606 9606 BIOGRID
CHEK2 CHEK2 Biochemical Activity 25361978 9606 9606 BIOGRID
CHEK2 CDC25C Biochemical Activity 25361978 9606 9606 BIOGRID
CHEK2 PSME3 Biochemical Activity 25361978 9606 9606 BIOGRID
CHEK2 BEX1 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 CCL5 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 CDH13 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 CYP17A1 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 DIRAS3 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 FAM84B Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 HOXC6 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 IL24 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 ITIH5 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 KLK7 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 KLK9 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 LYPD3 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 PRDM14 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 PSMC3IP Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 RHOBTB2 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 RNF20 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 ST14 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 WHSC1L1 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 BAALC Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 ENO1 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 GNAS Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 HMGN1 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 SLC25A6 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 PRMT2 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 STMN1 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 TLR3 Two-hybrid 25640309 9606 9606 BIOGRID
CHEK2 IL24 Affinity Capture-Western 25640309 9606 9606 BIOGRID
CHEK2 RNF20 Affinity Capture-Western 25640309 9606 9606 BIOGRID
CHEK2 SIAH2 Affinity Capture-Western 26751770 9606 9606 BIOGRID
CHEK2 SIAH2 Reconstituted Complex 26751770 9606 9606 BIOGRID
CHEK2 SIAH2 Biochemical Activity 26751770 9606 9606 BIOGRID
CHEK2 NFKB1 Two-hybrid 21466675 9606 9606 BIOGRID
CHEK2 ERBB2 Negative Genetic 28319113 9606 9606 BIOGRID
CHEK2 KMT2D Negative Genetic 28319113 9606 9606 BIOGRID
CHEK2 WEE1 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 CHEK1 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 CDC6 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 CDC73 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 BLM Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 RFC1 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 RAD17 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 FZR1 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 ATAD5 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 LLGL1 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 CDC14A Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 RPS10 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 WRN Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 ATR Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 DAAM1 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 TTN Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 BRD4 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK2 CDC25C Biochemical Activity 11053450 9606 9606 BIOGRID
CHEK2 PPM1D Reconstituted Complex 16311512 9606 9606 BIOGRID
CHEK2 PPM1D Affinity Capture-Western 16311512 9606 9606 BIOGRID
CHEK2 CDC25C Biochemical Activity 16311512 9606 9606 BIOGRID
CHEK2 NFKB1 Affinity Capture-Western 21466675 9606 9606 BIOGRID
CHEK2 CNTN2 Affinity Capture-Western 15107832 9606 9606 BIOGRID
CHEK2 CDC25C Biochemical Activity 12897801 9606 9606 BIOGRID
CHEK2 TP53 Biochemical Activity 12897801 9606 9606 BIOGRID
CHEK2 TP53 Reconstituted Complex 12897801 9606 9606 BIOGRID
CHEK2 CDKN1A Reconstituted Complex 12897801 9606 9606 BIOGRID
CHEK2 CDKN1A Biochemical Activity 12897801 9606 9606 BIOGRID
CHEK2 FHL1 Affinity Capture-Western 28094252 9606 9606 BIOGRID
CHEK2 CDC25C Affinity Capture-Western 28094252 9606 9606 BIOGRID
CHEK2 CDC25C Biochemical Activity 28094252 9606 9606 BIOGRID
CHEK2 CDK11B Co-purification 23178491 9606 9606 BIOGRID
CHEK2 USP7 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 CHEK2 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 SF3B1 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 UBR4 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 PPP2R1A Co-purification 23178491 9606 9606 BIOGRID
CHEK2 CSNK2A2 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 SF3B3 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 PKM Co-purification 23178491 9606 9606 BIOGRID
CHEK2 RBM25 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 DHX9 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 PPM1G Co-purification 23178491 9606 9606 BIOGRID
CHEK2 FBXO22 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 PRPF40A Co-purification 23178491 9606 9606 BIOGRID
CHEK2 MYBBP1A Co-purification 23178491 9606 9606 BIOGRID
CHEK2 SMC1A Co-purification 23178491 9606 9606 BIOGRID
CHEK2 HNRNPU Co-purification 23178491 9606 9606 BIOGRID
CHEK2 LMNB1 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 HNRNPK Co-purification 23178491 9606 9606 BIOGRID
CHEK2 PAICS Co-purification 23178491 9606 9606 BIOGRID
CHEK2 SF3B2 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 MCM7 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 SMC3 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 TPR Co-purification 23178491 9606 9606 BIOGRID
CHEK2 NONO Co-purification 23178491 9606 9606 BIOGRID
CHEK2 SMC4 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 BUB3 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 KPNB1 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 KPNA2 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 MCM3 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 EEF1G Co-purification 23178491 9606 9606 BIOGRID
CHEK2 HNRNPAB Co-purification 23178491 9606 9606 BIOGRID
CHEK2 PCBP1 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 MCM5 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 EFTUD2 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 PUF60 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 UBE2O Co-purification 23178491 9606 9606 BIOGRID
CHEK2 SFPQ Co-purification 23178491 9606 9606 BIOGRID
CHEK2 TARDBP Co-purification 23178491 9606 9606 BIOGRID
CHEK2 PPP2CA Co-purification 23178491 9606 9606 BIOGRID
CHEK2 FKBP4 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 XRCC5 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 SYNCRIP Co-purification 23178491 9606 9606 BIOGRID
CHEK2 CSNK2A1 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 LRRC8A Co-purification 23178491 9606 9606 BIOGRID
CHEK2 AP1B1 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 FARSA Co-purification 23178491 9606 9606 BIOGRID
CHEK2 RUVBL1 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 SMC2 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 GTF2I Co-purification 23178491 9606 9606 BIOGRID
CHEK2 EEF1D Co-purification 23178491 9606 9606 BIOGRID
CHEK2 EIF3A Co-purification 23178491 9606 9606 BIOGRID
CHEK2 PPP2R5C Co-purification 23178491 9606 9606 BIOGRID
CHEK2 PCBP2 Co-purification 23178491 9606 9606 BIOGRID
CHEK2 CDK11B Affinity Capture-Western 23178491 9606 9606 BIOGRID
CHEK2 CDK11B Reconstituted Complex 23178491 9606 9606 BIOGRID
CHEK2 CDK11B Biochemical Activity 23178491 9606 9606 BIOGRID
CHEK2 BRCA1 Affinity Capture-Western 12049740 9606 9606 BIOGRID
CHEK2 BRCA2 Biochemical Activity 18317453 9606 9606 BIOGRID
CHEK2 MAPT Biochemical Activity 20159774 9606 9606 BIOGRID
CHEK2 USP39 Affinity Capture-Western 30771428 9606 9606 BIOGRID
CHEK2 EBNA3A Affinity Capture-Western 14716295 9606 10376 BIOGRID
CHEK2 RL2 Protein-peptide 32001251 9606 10298 BIOGRID
CHEK2 RL2 Biochemical Activity 32001251 9606 10298 BIOGRID
 Annotation of CHEK2
 TCGA cancer survival map of CHEK2


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.
Reset Add The plot axis-x order will follow the list.


Calculate the hazards ratio based on Cox PH Model.
We use log2(TPM + 1) for log-scale.
All Add
Reset The plot is based on the datasets of list.


 Disease information of  CHEK2