TcoF overview
TcoF: DOT1L
GeneID: 8110
Name: Histone-lysine N-methyltransferase, H3 lysine-79-specific
Ensembl: ENSG00000104885
Species: Human
Class: NA
Family: Others
Disease: 1
Go term: 19
Pathway: 2
Hallmark: 2
Super Enhancer:

chr19:2149388-2152618 chr19:2164096-2168510 chr19:2161138-2174962 chr19:2154455-2169953 chr19:2162573-2172275 chr19:2153839-2188314 chr19:2154124-2187326 chr19:2160421-2188542 chr19:2153999-2172372 chr19:2154511-2187651 chr19:2162124-2174662 chr19:2163345-2174238 chr19:2162534-2177270 chr19:2163290-2174646 chr19:2163024-2187823 chr19:2163034-2190261 chr19:2209992-2228315 chr19:2161284-2170043 chr19:2162462-2174342 chr19:2153494-2192345 chr19:2159673-2171923 chr19:2161341-2174626 chr19:2161346-2174695 chr19:2149414-2171025 chr19:2149536-2177317 chr19:2149451-2177370 chr19:2149432-2172132 chr19:2149515-2190054 chr19:2149473-2172687 chr19:2149384-2170266 chr19:2149483-2182888 chr19:2149174-2170175 chr19:2144594-2177302 chr19:2144054-2177487 chr19:2149190-2202999 chr19:2149112-2172575 chr19:2149549-2177016 chr19:2148449-2174007 chr19:2149522-2170636 chr19:2149518-2177537 chr19:2149534-2170014 chr19:2149534-2170014 chr19:2147867-2183633 chr19:2149482-2177625 chr19:2149276-2171899 chr19:2149414-2190694 chr19:2149380-2172387 chr19:2145000-2176695 chr19:2149404-2187294 chr19:2145505-2188692 chr19:2145931-2188705 chr19:2149073-2172188 chr19:2149545-2174936 chr19:2148049-2171559 chr19:2148264-2171699 chr19:2149472-2171597 chr19:2149445-2170014 chr19:2129022-2190371 chr19:2129137-2189673 chr19:2149264-2190590 chr19:2149450-2172009 chr19:2149738-2171446 chr19:2149417-2175818

Enhancer:

chr19:2166440-2167850 chr19:2041200-2041830 chr19:2042520-2042600 chr19:2050950-2051090 chr19:2269740-2271380 chr19:2042660-2042760 chr19:2042870-2043120 chr19:2043200-2043500 chr19:2082000-2084060 chr19:2084800-2085170 chr19:2086150-2088590 chr19:2079140-2081340 chr19:2271530-2271780 chr19:2271950-2272730 chr19:2273490-2274630 chr19:2280940-2282080 chr19:2207680-2208930 chr19:2211840-2213530 chr19:2241350-2243380 chr19:2427040-2427250 chr19:2427320-2427410 chr19:2476400-2476530 chr19:2476630-2477020 chr19:2341010-2343200 chr19:2252800-2252910 chr19:2253000-2253610 chr19:2253790-2254180 chr19:1825940-1826870 chr19:2039860-2040130 chr19:2040170-2041030 chr19:2252070-2252240 chr19:2255340-2256380 chr19:2272820-2272970 chr19:2477250-2477480 chr19:2333620-2334600 chr19:2345330-2346890 chr19:1965860-1967730 chr19:1872320-1874420 chr19:1908960-1910680 chr19:2114300-2114740 chr19:2164260-2166420 chr19:2013010-2015290 chr19:2004990-2005540 chr19:2042030-2042430 chr19:2119760-2120580 chr19:2127200-2128660 chr19:2128870-2129080 chr19:2129160-2129310 chr19:2137810-2138610 chr19:2129460-2130400 chr19:1754850-1756620 chr19:2301940-2304060 chr19:2545680-2548040 chr19:1810680-1811480 chr19:1880140-1880890 chr19:1881050-1881230 chr19:1974250-1975710 chr19:1977010-1978300 chr19:2213640-2213840 chr19:2213990-2214460 chr19:2276490-2278140 chr19:2208970-2210140 chr19:2214600-2216270 chr19:2422250-2424080 chr19:2425490-2425620 chr19:2191240-2192770 chr19:2243540-2244110 chr19:2337620-2338750 chr19:2007160-2007620 chr19:2026840-2027240 chr19:2027400-2029900 chr19:2060460-2062830 chr19:2085330-2086020 chr19:2533250-2534680 chr19:2046280-2046360 chr19:2046470-2046600 chr19:2223490-2225380 chr19:2416810-2417990 chr19:2073420-2075920 chr19:2172570-2174550 chr19:2229140-2229440 chr19:2229500-2229780 chr19:2560960-2563040 chr19:2594210-2595120 chr19:2595210-2597700 chr19:2788360-2790410 chr19:2454180-2456660 chr19:2425270-2425350 chr19:2254300-2254440 chr19:1986650-1986820 chr19:1986980-1987160 chr19:1987250-1987490 chr19:1987690-1990000 chr19:1990200-1990710 chr19:1990820-1993010 chr19:1993180-1993880 chr19:2123400-2123820 chr19:2250760-2250840 chr19:2251010-2251090 chr19:2254480-2255200 chr19:2409300-2410250 chr19:2414020-2415660 chr19:2415840-2416530 chr19:2424260-2424990 chr19:2220220-2221970 chr19:2517730-2519100 chr19:2649600-2651350 chr19:2790630-2792350 chr19:2810770-2811590 chr19:2811730-2813110 chr19:2684980-2686980 chr19:2336400-2337440 chr19:2492550-2493240 chr19:2502930-2504890 chr19:2528180-2530540 chr19:2532080-2533190 chr19:2769090-2771260 chr19:2506200-2508360 chr19:2371650-2373310 chr19:2373960-2375910 chr19:1690200-1692230 chr19:1796260-1796700 chr19:2112970-2113330 chr19:2497860-2499600 chr19:2499740-2501400 chr19:2113410-2114120 chr19:1772900-1775150 chr19:1969960-1971740 chr19:2203420-2204970 chr19:2205240-2206100 chr19:2393240-2395580 chr19:2617820-2620070 chr19:2587000-2589300 chr19:1508110-1508440 chr19:2298760-2299410 chr19:2516540-2517260 chr19:2175530-2177630 chr19:1978340-1978440 chr19:1978510-1978600 chr19:1978750-1978850 chr19:1979090-1979160 chr19:1979250-1979310 chr19:2108770-2109080 chr19:1927430-1928360 chr19:2411460-2413690 chr19:2496930-2497560 chr19:1997460-1999640 chr19:1453610-1455140 chr19:1508570-1510140 chr19:1511160-1512960 chr19:1524250-1525300 chr19:1565000-1567460 chr19:2103230-2104660 chr19:2359950-2362090 chr19:2535510-2536940 chr19:2616550-2617620 chr19:2694300-2696280 chr19:2696490-2696890 chr19:2700370-2702640 chr19:2738220-2739940 chr19:2820120-2821820 chr19:2355100-2356830 chr19:2478260-2480660 chr19:1823780-1824100 chr19:2108490-2108680 chr19:2109210-2109580 chr19:2114820-2115210 chr19:2115420-2115530 chr19:2117370-2117870 chr19:2118270-2118500 chr19:2280600-2280840

Promoter:

chr19:2163932-2232577

 ChIP-seq based regulatory details of DOT1L
Sample ID Experiment target Biosample type Biosample term name GSM ID Tissue type Source
TcoF_00_30394 DOT1L cell line NCCIT GSM654638 Embryo ChIP-Atlas
 Downstream target genes of DOT1L
 Protein-protein interaction of DOT1L
OFFICIAL_SYMBOL_A OFFICIAL_SYMBOL_B EXPERIMENTAL_SYSTEM PUBMED_ID ORGANISM_A_ID ORGANISM_B_ID SOURCE
DOT1L MLLT3 Two-hybrid 16636056 9606 9606 BIOGRID
DOT1L MLLT3 Affinity Capture-Western 16636056 9606 9606 BIOGRID
DOT1L MLLT6 Two-hybrid 19864429 9606 9606 BIOGRID
DOT1L NPM1 Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L HNRNPM Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L MLLT3 Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L MLLT1 Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L MLLT10 Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L HIST1H1C Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L DDX21 Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L HIST1H2BB Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L GRWD1 Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L HNRNPU Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L HIST1H2AA Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L ALYREF Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L YBX3 Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L SYNCRIP Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L GNL3 Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L H1FX Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L HIST1H1A Affinity Capture-MS 20431927 9606 9606 BIOGRID
DOT1L NPM1 Affinity Capture-Western 20431927 9606 9606 BIOGRID
DOT1L DDX21 Affinity Capture-Western 20431927 9606 9606 BIOGRID
DOT1L HNRNPM Affinity Capture-Western 20431927 9606 9606 BIOGRID
DOT1L MLLT1 Affinity Capture-Western 20431927 9606 9606 BIOGRID
DOT1L SIRT1 Affinity Capture-Western 20431927 9606 9606 BIOGRID
DOT1L MLLT1 Affinity Capture-Western 20153263 9606 9606 BIOGRID
DOT1L AFF1 Affinity Capture-Western 21030982 9606 9606 BIOGRID
DOT1L HIST2H3C Biochemical Activity 21726816 9606 9606 BIOGRID
DOT1L STAT1 Affinity Capture-Western 22002246 9606 9606 BIOGRID
DOT1L HIST3H3 Biochemical Activity 22619169 9606 9606 BIOGRID
DOT1L BAG6 Affinity Capture-Western 22373577 9606 9606 BIOGRID
DOT1L HIST2H3C Affinity Capture-Western 22373577 9606 9606 BIOGRID
DOT1L MLLT1 Affinity Capture-Western 21873227 9606 9606 BIOGRID
DOT1L MLLT3 Affinity Capture-Western 21873227 9606 9606 BIOGRID
DOT1L KMT2A Affinity Capture-Western 22094252 9606 9606 BIOGRID
DOT1L MLLT6 Co-fractionation 26344197 9606 9606 BIOGRID
DOT1L MLLT3 Affinity Capture-MS 26496610 9606 9606 BIOGRID
DOT1L MLLT6 Affinity Capture-MS 26496610 9606 9606 BIOGRID
DOT1L MAPK7 Affinity Capture-MS 26496610 9606 9606 BIOGRID
DOT1L MLLT10 Affinity Capture-MS 26496610 9606 9606 BIOGRID
DOT1L EBNA1BP2 Affinity Capture-MS 26496610 9606 9606 BIOGRID
DOT1L IBTK Affinity Capture-MS 26496610 9606 9606 BIOGRID
DOT1L NIN Affinity Capture-MS 26496610 9606 9606 BIOGRID
DOT1L PARP16 Affinity Capture-MS 26496610 9606 9606 BIOGRID
DOT1L BRINP1 Affinity Capture-MS 26496610 9606 9606 BIOGRID
DOT1L MCL1 Negative Genetic 28319085 9606 9606 BIOGRID
DOT1L MST1R Negative Genetic 28319085 9606 9606 BIOGRID
DOT1L NTRK1 Positive Genetic 28319085 9606 9606 BIOGRID
DOT1L NR5A1 Positive Genetic 28319085 9606 9606 BIOGRID
DOT1L MYCN Affinity Capture-Western 28209620 9606 9606 BIOGRID
DOT1L MLLT10 Affinity Capture-MS 24981860 9606 9606 BIOGRID
 Annotation of DOT1L
 TCGA cancer survival map of DOT1L


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.
Reset Add The plot axis-x order will follow the list.


Calculate the hazards ratio based on Cox PH Model.
We use log2(TPM + 1) for log-scale.
All Add
Reset The plot is based on the datasets of list.


 Disease information of  DOT1L