TcoF overview
TcoF: JAK2
GeneID: 10656
Name: Tyrosine-protein kinase JAK2
Ensembl: ENSG00000096968
Species: Human
Class: class 2
Family: Others
Disease: 53
Go term: 118
Pathway: 88
Hallmark: 2
Super Enhancer:

chr9:4983628-4986370 chr9:4970744-4986935 chr9:4975733-4986621 chr9:4974946-4988619 chr9:4969807-4987244 chr9:4922310-5017824 chr9:4923466-4988682 chr9:4983261-4989126 chr9:4983261-4989126 chr9:4982243-4990014 chr9:4978299-4991498

Enhancer:

chr9:4985630-4985930 chr9:4665270-4666210 chr9:4666250-4666430 chr9:4738510-4740940 chr9:4986020-4987560 chr9:4793230-4795500 chr9:4814080-4816290 chr9:4935850-4936570 chr9:4938550-4940680 chr9:4970040-4972480 chr9:4689030-4691040 chr9:4752630-4753800 chr9:4973770-4974850 chr9:4529850-4532000 chr9:4831850-4833150 chr9:4833230-4834140 chr9:4855170-4856560 chr9:5009810-5010140 chr9:5019880-5021110 chr9:4827670-4828010 chr9:4987580-4989300 chr9:5268050-5270540

Promoter:

chr9:4984390-5128183

 ChIP-seq based regulatory details of JAK2
Sample ID Experiment target Biosample type Biosample term name GSM ID Tissue type Source
 Downstream target genes of JAK2
 Protein-protein interaction of JAK2
OFFICIAL_SYMBOL_A OFFICIAL_SYMBOL_B EXPERIMENTAL_SYSTEM PUBMED_ID ORGANISM_A_ID ORGANISM_B_ID SOURCE
JAK2 PRMT5 Two-hybrid 10531356 9606 9606 BIOGRID
JAK2 SOCS1 Two-hybrid 10064597 9606 9606 BIOGRID
JAK2 IL12RB2 Affinity Capture-Western 10198225 9606 9606 BIOGRID
JAK2 EPOR Affinity Capture-Western 11779507 9606 9606 BIOGRID
JAK2 SH2B2 Biochemical Activity 10374881 9606 9606 BIOGRID
JAK2 DNAJA3 Affinity Capture-Western 11679576 9606 9606 BIOGRID
JAK2 HSPA8 Affinity Capture-Western 11679576 9606 9606 BIOGRID
JAK2 TEC Affinity Capture-Western 9178903 9606 9606 BIOGRID
JAK2 PTPN12 Affinity Capture-Western 11731619 9606 9606 BIOGRID
JAK2 CSF2RB Reconstituted Complex 7775438 9606 9606 BIOGRID
JAK2 VAV1 Affinity Capture-Western 9162069 9606 9606 BIOGRID
JAK2 VAV1 Biochemical Activity 9162069 9606 9606 BIOGRID
JAK2 SIRPA Affinity Capture-Western 10842184 9606 9606 BIOGRID
JAK2 IRS1 Biochemical Activity 9492017 9606 9606 BIOGRID
JAK2 GRB2 Affinity Capture-Western 7500025 9606 9606 BIOGRID
JAK2 EGFR Affinity Capture-Western 10358079 9606 9606 BIOGRID
JAK2 PTK2B Affinity Capture-Western 11818507 9606 9606 BIOGRID
JAK2 PTPN11 Biochemical Activity 8995399 9606 9606 BIOGRID
JAK2 STAT5A Two-hybrid 9047382 9606 9606 BIOGRID
JAK2 STAT5B Two-hybrid 9047382 9606 9606 BIOGRID
JAK2 STAT5A Reconstituted Complex 9047382 9606 9606 BIOGRID
JAK2 SOCS3 Affinity Capture-Western 10882725 9606 9606 BIOGRID
JAK2 PTPN6 Affinity Capture-Western 8943354 9606 9606 BIOGRID
JAK2 SOCS3 Two-hybrid 10421843 9606 9606 BIOGRID
JAK2 SOCS3 Reconstituted Complex 10421843 9606 9606 BIOGRID
JAK2 HTR2A Affinity Capture-Western 9169451 9606 9606 BIOGRID
JAK2 SOCS1 Two-hybrid 9202126 9606 9606 BIOGRID
JAK2 VAV1 Affinity Capture-Western 7530656 9606 9606 BIOGRID
JAK2 SH2B1 Two-hybrid 9343427 9606 9606 BIOGRID
JAK2 PPP2R1B Affinity Capture-Western 11440634 9606 9606 BIOGRID
JAK2 PTPN11 Biochemical Activity 8639815 9606 9606 BIOGRID
JAK2 IRS1 Affinity Capture-Western 11208867 9606 9606 BIOGRID
JAK2 TUB Biochemical Activity 10455176 9606 9606 BIOGRID
JAK2 TSHR Affinity Capture-Western 10809230 9606 9606 BIOGRID
JAK2 EPOR Reconstituted Complex 8343951 9606 9606 BIOGRID
JAK2 PTPN6 Affinity Capture-Western 10772872 9606 9606 BIOGRID
JAK2 STAT3 Affinity Capture-Western 9211920 9606 9606 BIOGRID
JAK2 SOCS1 Affinity Capture-Western 11971965 9606 9606 BIOGRID
JAK2 SOCS3 Reconstituted Complex 9344848 9606 9606 BIOGRID
JAK2 SOCS1 Reconstituted Complex 9344848 9606 9606 BIOGRID
JAK2 PTPN11 Affinity Capture-Western 8912646 9606 9606 BIOGRID
JAK2 STAM Biochemical Activity 9133424 9606 9606 BIOGRID
JAK2 STAT1 Affinity Capture-Western 20353823 9606 9606 BIOGRID
JAK2 HSP90AA1 Affinity Capture-Western 20353823 9606 9606 BIOGRID
JAK2 HSP90AB1 Affinity Capture-Western 20353823 9606 9606 BIOGRID
JAK2 PRMT5 Affinity Capture-Western 21316606 9606 9606 BIOGRID
JAK2 PRMT5 Biochemical Activity 21316606 9606 9606 BIOGRID
JAK2 PRLR Affinity Capture-Western 20962278 9606 9606 BIOGRID
JAK2 SKP2 Affinity Capture-Western 21119685 9606 9606 BIOGRID
JAK2 ASB2 Affinity Capture-Western 21119685 9606 9606 BIOGRID
JAK2 GTF2I Biochemical Activity 11313464 9606 9606 BIOGRID
JAK2 HIST3H3 Biochemical Activity 19783980 9606 9606 BIOGRID
JAK2 SOCS1 Affinity Capture-Western 14522994 9606 9606 BIOGRID
JAK2 CDKN1B Biochemical Activity 21423214 9606 9606 BIOGRID
JAK2 CDKN1B Affinity Capture-Western 21423214 9606 9606 BIOGRID
JAK2 VHL Affinity Capture-Western 21685897 9606 9606 BIOGRID
JAK2 SOCS1 Affinity Capture-Western 11314018 9606 9606 BIOGRID
JAK2 SOCS3 Affinity Capture-Western 15514089 9606 9606 BIOGRID
JAK2 MAP3K5 Affinity Capture-Western 19287004 9606 9606 BIOGRID
JAK2 MAP3K5 Biochemical Activity 19287004 9606 9606 BIOGRID
JAK2 SOCS1 Affinity Capture-Western 19287004 9606 9606 BIOGRID
JAK2 STAT5A Biochemical Activity 7925280 9606 9606 BIOGRID
JAK2 JAK2 Biochemical Activity 8609418 9606 9606 BIOGRID
JAK2 JAK2 Biochemical Activity 8041779 9606 9606 BIOGRID
JAK2 EGFR Protein-peptide 16273093 9606 9606 BIOGRID
JAK2 ERBB3 Protein-peptide 16273093 9606 9606 BIOGRID
JAK2 STAT1 Affinity Capture-Western 15284024 9606 9606 BIOGRID
JAK2 STAT3 Affinity Capture-Western 15284024 9606 9606 BIOGRID
JAK2 CALM1 Affinity Capture-Western 12626508 9606 9606 BIOGRID
JAK2 PLCG1 Affinity Capture-Western 14978237 9606 9606 BIOGRID
JAK2 SH2B1 Two-hybrid 15767667 9606 9606 BIOGRID
JAK2 JAK2 Biochemical Activity 15767667 9606 9606 BIOGRID
JAK2 JAK2 Biochemical Activity 16609991 9606 9606 BIOGRID
JAK2 RBMX Two-hybrid 21988832 9606 9606 BIOGRID
JAK2 TRAF6 Two-hybrid 21988832 9606 9606 BIOGRID
JAK2 EZH2 Biochemical Activity 24469040 9606 9606 BIOGRID
JAK2 STAT5B Biochemical Activity 24354892 9606 9606 BIOGRID
JAK2 JAK2 Biochemical Activity 24354892 9606 9606 BIOGRID
JAK2 SOCS3 Reconstituted Complex 24354892 9606 9606 BIOGRID
JAK2 EMD Affinity Capture-MS 25852190 9606 9606 BIOGRID
JAK2 KPNB1 Affinity Capture-MS 25852190 9606 9606 BIOGRID
JAK2 NAP1L1 Affinity Capture-MS 25852190 9606 9606 BIOGRID
JAK2 RCN1 Affinity Capture-MS 25852190 9606 9606 BIOGRID
JAK2 SLC2A1 Affinity Capture-MS 25852190 9606 9606 BIOGRID
JAK2 UBP1 Affinity Capture-MS 25852190 9606 9606 BIOGRID
JAK2 EGFR Biochemical Activity 23838182 9606 9606 BIOGRID
JAK2 STAT3 Biochemical Activity 23838182 9606 9606 BIOGRID
JAK2 PIK3R1 Negative Genetic 28319113 9606 9606 BIOGRID
JAK2 STAT3 Biochemical Activity 27351213 9606 9606 BIOGRID
JAK2 ARL11 Two-hybrid 27229929 9606 9606 BIOGRID
JAK2 HSFY1 Two-hybrid 27229929 9606 9606 BIOGRID
JAK2 CBL Affinity Capture-Western 28676638 9606 9606 BIOGRID
JAK2 CBL Co-localization 28676638 9606 9606 BIOGRID
JAK2 CBL Reconstituted Complex 28676638 9606 9606 BIOGRID
JAK2 SOCS1 Affinity Capture-Western 14517242 9606 9606 BIOGRID
JAK2 SOCS3 Affinity Capture-Western 14517242 9606 9606 BIOGRID
JAK2 PIK3R1 Affinity Capture-Western 10026141 9606 9606 BIOGRID
JAK2 JAK2 Biochemical Activity 10026141 9606 9606 BIOGRID
JAK2 PIK3R1 Reconstituted Complex 10026141 9606 9606 BIOGRID
JAK2 SH2B1 Affinity Capture-Western 15316008 9606 9606 BIOGRID
JAK2 IRS1 Affinity Capture-Western 15316008 9606 9606 BIOGRID
JAK2 SOCS3 Reconstituted Complex 29752723 9606 9606 BIOGRID
JAK2 LNX1 Affinity Capture-Western 30634502 9606 9606 BIOGRID
JAK2 LDOC1 Affinity Capture-Western 30634502 9606 9606 BIOGRID
JAK2 LDOC1 Co-localization 30634502 9606 9606 BIOGRID
JAK2 JAK1 Biochemical Activity 32001089 9606 9606 BIOGRID
JAK2 Ifngr1 Reconstituted Complex 7499845 9606 10090 BIOGRID
JAK2 Lmo4 Affinity Capture-Western 15677447 9606 10090 BIOGRID
 Annotation of JAK2
 TCGA cancer survival map of JAK2


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.
Reset Add The plot axis-x order will follow the list.


Calculate the hazards ratio based on Cox PH Model.
We use log2(TPM + 1) for log-scale.
All Add
Reset The plot is based on the datasets of list.


 Disease information of  JAK2