TcoF overview
TcoF: PRKDC
GeneID: 11168
Name: DNA-dependent protein kinase catalytic subunit
Ensembl: ENSG00000253729
Species: Human
Class: class HC
Family: Others
Disease: 22
Go term: 75
Pathway: 13
Hallmark: 7
Super Enhancer:

chr8:48753753-48783924 chr8:48721280-48818953 chr8:48858832-48882819

Enhancer:

chr8:48648560-48649470 chr8:48813830-48815120 chr8:48686940-48689400 chr8:48793410-48793930 chr8:49052960-49055140 chr8:48949120-48950820 chr8:48864300-48865920 chr8:48853300-48855760 chr8:48434320-48435420 chr8:48438660-48439290 chr8:48439370-48439960 chr8:48521070-48521820 chr8:48521910-48524340 chr8:48524380-48525750 chr8:48594570-48596510 chr8:48806440-48807780 chr8:48811130-48812930 chr8:48886400-48887290 chr8:48790530-48791830 chr8:48700800-48701460 chr8:48734350-48736410 chr8:48739420-48740720 chr8:48792220-48793120 chr8:48815800-48817420 chr8:48933760-48934640 chr8:48878970-48879920 chr8:48880050-48882350 chr8:48894750-48896180 chr8:48953680-48955590 chr8:48350620-48352880 chr8:48452150-48453580 chr8:48533740-48534650 chr8:48575260-48576960 chr8:48581100-48582620 chr8:48596690-48597520 chr8:48636610-48637780 chr8:48644790-48645430 chr8:48645480-48647860 chr8:49186020-49187340 chr8:49193300-49195410 chr8:49235880-49237580 chr8:49288490-49290980 chr8:49291860-49293870 chr8:49294050-49295000 chr8:49320370-49320670 chr8:49321080-49321470 chr8:48545100-48546940 chr8:49217300-49218660 chr8:49104000-49105500 chr8:49172750-49174390 chr8:48817770-48818730 chr8:48473580-48474420 chr8:48748220-48748800 chr8:48763740-48765230 chr8:48771780-48772170 chr8:48891220-48892430 chr8:48550310-48552280 chr8:48586500-48588980 chr8:49059090-49060920 chr8:49302130-49304090 chr8:49447660-49449240 chr8:49493640-49495770 chr8:49501740-49503940 chr8:49533090-49534820 chr8:48235580-48236630 chr8:48268420-48269980 chr8:48277380-48279400 chr8:48289420-48291270 chr8:48291530-48292110 chr8:48281310-48283780 chr8:49086580-49087370 chr8:49176520-49177860 chr8:49254960-49256870 chr8:48835920-48836750 chr8:48506130-48506590 chr8:48744490-48746750 chr8:48857100-48858410 chr8:49220490-49222450 chr8:48510280-48511500 chr8:48743760-48744370

Promoter:

chr8:48685669-48872743

 ChIP-seq based regulatory details of PRKDC
Sample ID Experiment target Biosample type Biosample term name GSM ID Tissue type Source
TcoF_00_21095 PRKDC cell line None GSM1340089 None Cistrome
TcoF_00_21096 PRKDC cell line None GSM1340090 None Cistrome
TcoF_00_20910 PRKDC cell line MCF-7 GSM1470001 Breast Cistrome
TcoF_00_20911 PRKDC cell line MCF-7 GSM1470002 Breast Cistrome
TcoF_00_20912 PRKDC cell line MCF-7 GSM1470003 Breast Cistrome
TcoF_00_20913 PRKDC cell line MCF-7 GSM1470004 Breast Cistrome
TcoF_00_20914 PRKDC cell line MCF-7 GSM1470005 Breast Cistrome
TcoF_00_20915 PRKDC cell line MCF-7 GSM1470006 Breast Cistrome
 Downstream target genes of PRKDC
 Protein-protein interaction of PRKDC
OFFICIAL_SYMBOL_A OFFICIAL_SYMBOL_B EXPERIMENTAL_SYSTEM PUBMED_ID ORGANISM_A_ID ORGANISM_B_ID SOURCE
PRKDC AR Affinity Capture-MS 15640154 9606 9606 BIOGRID
PRKDC AP1B1 Protein-peptide 10608806 9606 9606 BIOGRID
PRKDC ATM Protein-peptide 10608806 9606 9606 BIOGRID
PRKDC BRCA1 Protein-peptide 10608806 9606 9606 BIOGRID
PRKDC CHEK1 Protein-peptide 10608806 9606 9606 BIOGRID
PRKDC E4F1 Protein-peptide 10608806 9606 9606 BIOGRID
PRKDC LIG4 Protein-peptide 10608806 9606 9606 BIOGRID
PRKDC MRE11A Protein-peptide 10608806 9606 9606 BIOGRID
PRKDC RAD17 Protein-peptide 10608806 9606 9606 BIOGRID
PRKDC RBBP8 Protein-peptide 10608806 9606 9606 BIOGRID
PRKDC TP53 Protein-peptide 10608806 9606 9606 BIOGRID
PRKDC WRN Protein-peptide 10608806 9606 9606 BIOGRID
PRKDC TP53 Biochemical Activity 12756247 9606 9606 BIOGRID
PRKDC NCOA6 Biochemical Activity 10823961 9606 9606 BIOGRID
PRKDC KAT2A Biochemical Activity 9488450 9606 9606 BIOGRID
PRKDC RPA2 Affinity Capture-Western 10064605 9606 9606 BIOGRID
PRKDC XRCC6 Affinity Capture-Western 10064605 9606 9606 BIOGRID
PRKDC RPA2 Reconstituted Complex 10064605 9606 9606 BIOGRID
PRKDC RPA1 Reconstituted Complex 10064605 9606 9606 BIOGRID
PRKDC C1D Two-hybrid 9679063 9606 9606 BIOGRID
PRKDC C1D Biochemical Activity 9679063 9606 9606 BIOGRID
PRKDC TP53 Biochemical Activity 9679063 9606 9606 BIOGRID
PRKDC C1D Affinity Capture-Western 9679063 9606 9606 BIOGRID
PRKDC WRN Biochemical Activity 11889123 9606 9606 BIOGRID
PRKDC IKBKB Biochemical Activity 9632806 9606 9606 BIOGRID
PRKDC CHUK Biochemical Activity 9632806 9606 9606 BIOGRID
PRKDC AKT2 Biochemical Activity 16221682 9606 9606 BIOGRID
PRKDC ILF3 Co-purification 9442054 9606 9606 BIOGRID
PRKDC ILF2 Co-purification 9442054 9606 9606 BIOGRID
PRKDC EIF2S2 Co-purification 9442054 9606 9606 BIOGRID
PRKDC NCF1 Biochemical Activity 9914162 9606 9606 BIOGRID
PRKDC NCF2 Biochemical Activity 9914162 9606 9606 BIOGRID
PRKDC NCF4 Biochemical Activity 9914162 9606 9606 BIOGRID
PRKDC MAPK8 Biochemical Activity 11749722 9606 9606 BIOGRID
PRKDC MAPK9 Biochemical Activity 11749722 9606 9606 BIOGRID
PRKDC CIB1 Two-hybrid 9372844 9606 9606 BIOGRID
PRKDC ATM Affinity Capture-Western 10464290 9606 9606 BIOGRID
PRKDC DCLRE1C Reconstituted Complex 11955432 9606 9606 BIOGRID
PRKDC DCLRE1C Biochemical Activity 11955432 9606 9606 BIOGRID
PRKDC SIRT6 Co-localization 20157594 9606 9606 BIOGRID
PRKDC AIRE Affinity Capture-Western 20085707 9606 9606 BIOGRID
PRKDC POU2F1 Biochemical Activity 17213819 9606 9606 BIOGRID
PRKDC KAT5 Affinity Capture-Western 16603769 9606 9606 BIOGRID
PRKDC H2AFX Biochemical Activity 14627815 9606 9606 BIOGRID
PRKDC POU2F1 Biochemical Activity 14612514 9606 9606 BIOGRID
PRKDC PDX1 Biochemical Activity 16166097 9606 9606 BIOGRID
PRKDC AICDA Affinity Capture-Western 15634916 9606 9606 BIOGRID
PRKDC H2AFX Biochemical Activity 15613478 9606 9606 BIOGRID
PRKDC DHX9 Biochemical Activity 15613478 9606 9606 BIOGRID
PRKDC DHX9 Co-fractionation 15613478 9606 9606 BIOGRID
PRKDC HDAC3 Biochemical Activity 17242407 9606 9606 BIOGRID
PRKDC BIRC5 Affinity Capture-Western 20394854 9606 9606 BIOGRID
PRKDC H2AFX Biochemical Activity 20356835 9606 9606 BIOGRID
PRKDC HIST1H1A Biochemical Activity 20356835 9606 9606 BIOGRID
PRKDC PPP2CA Affinity Capture-Western 20065038 9606 9606 BIOGRID
PRKDC PPP6C Affinity Capture-Western 20065038 9606 9606 BIOGRID
PRKDC PPP6R1 Affinity Capture-Western 20065038 9606 9606 BIOGRID
PRKDC PPP6R2 Affinity Capture-Western 20065038 9606 9606 BIOGRID
PRKDC PPP6R3 Affinity Capture-Western 20065038 9606 9606 BIOGRID
PRKDC PRKDC Biochemical Activity 20065038 9606 9606 BIOGRID
PRKDC SP1 Biochemical Activity 8422676 9606 9606 BIOGRID
PRKDC HOXB7 Affinity Capture-Western 17308091 9606 9606 BIOGRID
PRKDC XRCC5 Affinity Capture-Western 15758953 9606 9606 BIOGRID
PRKDC CTDP1 Biochemical Activity 21450944 9606 9606 BIOGRID
PRKDC CTDP1 Protein-peptide 21450944 9606 9606 BIOGRID
PRKDC ILF3 Affinity Capture-Western 21969602 9606 9606 BIOGRID
PRKDC XRCC6 Affinity Capture-Western 21969602 9606 9606 BIOGRID
PRKDC XRCC5 Affinity Capture-Western 22404984 9606 9606 BIOGRID
PRKDC XRCC5 Co-localization 22404984 9606 9606 BIOGRID
PRKDC CSNK2A1 Affinity Capture-Western 22404984 9606 9606 BIOGRID
PRKDC HIST1H3A Co-localization 22404984 9606 9606 BIOGRID
PRKDC HNRNPA1 Biochemical Activity 14704337 9606 9606 BIOGRID
PRKDC HNRNPC Biochemical Activity 14704337 9606 9606 BIOGRID
PRKDC TP53 Affinity Capture-Western 19918261 9606 9606 BIOGRID
PRKDC ARHGEF6 Affinity Capture-Western 19918261 9606 9606 BIOGRID
PRKDC TP53 Biochemical Activity 9363941 9606 9606 BIOGRID
PRKDC VPRBP Biochemical Activity 22184063 9606 9606 BIOGRID
PRKDC H2AFX Biochemical Activity 22184063 9606 9606 BIOGRID
PRKDC DCLRE1C Biochemical Activity 15456891 9606 9606 BIOGRID
PRKDC MBP Biochemical Activity 15147269 9606 9606 BIOGRID
PRKDC XPA Biochemical Activity 16540648 9606 9606 BIOGRID
PRKDC RPA2 Biochemical Activity 16540648 9606 9606 BIOGRID
PRKDC RPA2 Biochemical Activity 9295339 9606 9606 BIOGRID
PRKDC NR3C1 Biochemical Activity 9038175 9606 9606 BIOGRID
PRKDC XRCC4 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC EFTUD2 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC PRPF8 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC CWC27 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC THOC6 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC YBX1 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC TRA2B Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC U2AF2 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC RBM25 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC DHX38 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC RAD21 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC SRP14 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC RPS11 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC SMARCA5 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC SRSF10 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC SRP54 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC PHGDH Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC RANBP2 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC PTER Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC THYN1 Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC TPR Co-fractionation 22939629 9606 9606 BIOGRID
PRKDC PGR Biochemical Activity 10750018 9606 9606 BIOGRID
PRKDC XRCC6 Biochemical Activity 10750018 9606 9606 BIOGRID
PRKDC XRCC5 Biochemical Activity 10750018 9606 9606 BIOGRID
PRKDC PRKDC Biochemical Activity 10750018 9606 9606 BIOGRID
PRKDC AKT1 Biochemical Activity 15262962 9606 9606 BIOGRID
PRKDC AKT1 Affinity Capture-Western 15262962 9606 9606 BIOGRID
PRKDC LIG4 Biochemical Activity 15194694 9606 9606 BIOGRID
PRKDC GSK3A Biochemical Activity 15678105 9606 9606 BIOGRID
PRKDC GSK3B Biochemical Activity 15678105 9606 9606 BIOGRID
PRKDC AKT2 Biochemical Activity 15678105 9606 9606 BIOGRID
PRKDC AKT1 Reconstituted Complex 15678105 9606 9606 BIOGRID
PRKDC AKT1 Affinity Capture-Western 15678105 9606 9606 BIOGRID
PRKDC SRF Biochemical Activity 8407951 9606 9606 BIOGRID
PRKDC JUN Biochemical Activity 8464713 9606 9606 BIOGRID
PRKDC DCLRE1C Affinity Capture-Western 16857680 9606 9606 BIOGRID
PRKDC XRCC5 Affinity Capture-Western 16857680 9606 9606 BIOGRID
PRKDC EIF4EBP1 Biochemical Activity 10713094 9606 9606 BIOGRID
PRKDC TP53 Biochemical Activity 10713094 9606 9606 BIOGRID
PRKDC CHEK2 Biochemical Activity 10713094 9606 9606 BIOGRID
PRKDC RPA2 Biochemical Activity 10713094 9606 9606 BIOGRID
PRKDC XRCC5 Co-crystal Structure 20023628 9606 9606 BIOGRID
PRKDC CIB1 Affinity Capture-Western 15190070 9606 9606 BIOGRID
PRKDC TP53 Biochemical Activity 10608806 9606 9606 BIOGRID
PRKDC CTPS2 Co-fractionation 22863883 9606 9606 BIOGRID
PRKDC GTF2I Co-fractionation 22863883 9606 9606 BIOGRID
PRKDC PRDX1 Co-fractionation 22863883 9606 9606 BIOGRID
PRKDC TP53 Biochemical Activity 9744860 9606 9606 BIOGRID
PRKDC TP53 Biochemical Activity 25362358 9606 9606 BIOGRID
PRKDC RASSF1 Protein-peptide 10608806 9606 9606 BIOGRID
PRKDC ANAPC2 Affinity Capture-Western 26221070 9606 9606 BIOGRID
PRKDC FZR1 Affinity Capture-Western 26221070 9606 9606 BIOGRID
PRKDC ALOX15 Affinity Capture-Western 18785202 9606 9606 BIOGRID
PRKDC RPA2 Biochemical Activity 8943020 9606 9606 BIOGRID
PRKDC XRCC1 Affinity Capture-Western 18678286 9606 9606 BIOGRID
PRKDC RRM2 Negative Genetic 28319113 9606 9606 BIOGRID
PRKDC VHL Negative Genetic 28319113 9606 9606 BIOGRID
PRKDC FANCD2 Synthetic Lethality 24036544 9606 9606 BIOGRID
PRKDC HIF1A Affinity Capture-Western 15272235 9606 9606 BIOGRID
PRKDC TOP1 Affinity Capture-Western 28415827 9606 9606 BIOGRID
PRKDC TOP1 Biochemical Activity 28415827 9606 9606 BIOGRID
PRKDC RNF144A Affinity Capture-Western 28450160 9606 9606 BIOGRID
PRKDC TP53 Affinity Capture-Western 11751391 9606 9606 BIOGRID
PRKDC TP53 Biochemical Activity 10601022 9606 9606 BIOGRID
PRKDC TP53 Protein-peptide 8940078 9606 9606 BIOGRID
PRKDC TSPO Negative Genetic 28319085 9606 9606 BIOGRID
PRKDC RPS6KA2 Negative Genetic 28319085 9606 9606 BIOGRID
PRKDC SSTR4 Negative Genetic 28319085 9606 9606 BIOGRID
PRKDC XRCC5 Co-crystal Structure 28154079 9606 9606 BIOGRID
PRKDC FH Biochemical Activity 26237645 9606 9606 BIOGRID
PRKDC XRCC4 Biochemical Activity 9259561 9606 9606 BIOGRID
PRKDC PRKDC Biochemical Activity 25223785 9606 9606 BIOGRID
PRKDC BRCA1 Affinity Capture-Western 25223785 9606 9606 BIOGRID
PRKDC BRCA1 Reconstituted Complex 25223785 9606 9606 BIOGRID
PRKDC FLNA Co-localization 20305393 9606 9606 BIOGRID
PRKDC CHEK2 Biochemical Activity 17171639 9606 9606 BIOGRID
PRKDC XRCC6 Affinity Capture-Western 28345663 9606 9606 BIOGRID
PRKDC XRCC5 Affinity Capture-Western 28345663 9606 9606 BIOGRID
PRKDC KIAA1217 Proximity Label-MS 30021884 9606 9606 BIOGRID
PRKDC FAM161A Proximity Label-MS 30021884 9606 9606 BIOGRID
PRKDC PWWP2B Proximity Label-MS 30021884 9606 9606 BIOGRID
PRKDC TBC1D28 Proximity Label-MS 30021884 9606 9606 BIOGRID
PRKDC NRXN1 Proximity Label-MS 30021884 9606 9606 BIOGRID
PRKDC LAMC3 Proximity Label-MS 30021884 9606 9606 BIOGRID
PRKDC ZNF840P Proximity Label-MS 30021884 9606 9606 BIOGRID
PRKDC TIAM2 Proximity Label-MS 30021884 9606 9606 BIOGRID
PRKDC SYNE2 Proximity Label-MS 30021884 9606 9606 BIOGRID
PRKDC GTPBP4 Proximity Label-MS 30021884 9606 9606 BIOGRID
PRKDC SFPQ Affinity Capture-Western 30725116 9606 9606 BIOGRID
PRKDC HIST1H1A Biochemical Activity 15671175 9606 9913 BIOGRID
PRKDC tat Biochemical Activity 21450944 9606 11676 BIOGRID
 Annotation of PRKDC
 TCGA cancer survival map of PRKDC


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.
Reset Add The plot axis-x order will follow the list.


Calculate the hazards ratio based on Cox PH Model.
We use log2(TPM + 1) for log-scale.
All Add
Reset The plot is based on the datasets of list.


 Disease information of  PRKDC