TcoF overview
TcoF: PSEN1
GeneID: 5784
Name: Presenilin-1 CTF12
Ensembl: ENSG00000080815
Species: Human
Class: class HC
Family: Others
Disease: 46
Go term: 138
Pathway: 16
Hallmark: 4
Super Enhancer:

chr14:73577314-73610574

Enhancer:

chr14:73458660-73459850 chr14:73490220-73490730 chr14:73491650-73493630 chr14:73570190-73570950 chr14:73741350-73741910 chr14:73831700-73833600 chr14:73833690-73834800 chr14:73712400-73712780 chr14:73711470-73712340 chr14:73809300-73811540 chr14:73423900-73425310 chr14:73471480-73472930 chr14:73744000-73745980 chr14:73728000-73729050 chr14:73259880-73260260 chr14:73278970-73279950 chr14:73342850-73344880 chr14:73357420-73358850 chr14:73603290-73605570 chr14:73806390-73806880 chr14:73806950-73808010 chr14:73923240-73925190 chr14:73704300-73706480 chr14:73731040-73731290 chr14:73731440-73732070 chr14:73921940-73923090 chr14:73612030-73614500 chr14:73942840-73945180 chr14:73608760-73610140 chr14:73755520-73757660 chr14:73757780-73759440 chr14:73771010-73772790 chr14:73883260-73883490 chr14:73938300-73940180 chr14:73717740-73718370 chr14:73718540-73718720 chr14:73718850-73719350 chr14:73749520-73750780 chr14:73836210-73837740 chr14:73664840-73665560 chr14:73829130-73831000 chr14:74194230-74196340 chr14:74225520-74226470 chr14:73074290-73076250 chr14:73079230-73081430 chr14:73085730-73086000 chr14:73086080-73086610 chr14:73104340-73105400 chr14:73109170-73111190 chr14:73112610-73114240 chr14:73118860-73119210 chr14:73131000-73132790 chr14:73145200-73147200 chr14:73181210-73183280 chr14:73212020-73214290 chr14:73221220-73222670 chr14:73245010-73246700 chr14:73246970-73249420 chr14:73315820-73316610 chr14:73316830-73317440 chr14:73322240-73323030 chr14:73329200-73331700 chr14:73427830-73429340 chr14:73429380-73431020 chr14:73431720-73432340 chr14:73654640-73656070 chr14:73676330-73677030 chr14:73706540-73707020 chr14:73918690-73920530 chr14:73992630-73993980 chr14:74036590-74038780 chr14:74059120-74060400 chr14:74111750-74113550 chr14:73267380-73269390 chr14:73294810-73296210 chr14:73474590-73476200 chr14:73525410-73527880 chr14:73571770-73572290 chr14:73881070-73882850 chr14:74011880-74012710 chr14:74043090-74044670 chr14:73639100-73640270 chr14:73227350-73229780 chr14:73452440-73453490 chr14:73802040-73803760 chr14:73725770-73725970 chr14:74083900-74085930 chr14:73563810-73566060 chr14:73636640-73637500 chr14:73174800-73176120 chr14:73479860-73482050 chr14:73302300-73303600 chr14:73590690-73593040 chr14:73632800-73635000 chr14:73789910-73791930 chr14:73888950-73889660 chr14:73349580-73351670 chr14:73792240-73794130 chr14:73726250-73727410 chr14:73558520-73558990 chr14:74196690-74198400

Promoter:

chr14:73603126-73690399

 ChIP-seq based regulatory details of PSEN1
Sample ID Experiment target Biosample type Biosample term name GSM ID Tissue type Source
 Downstream target genes of PSEN1
 Protein-protein interaction of PSEN1
OFFICIAL_SYMBOL_A OFFICIAL_SYMBOL_B EXPERIMENTAL_SYSTEM PUBMED_ID ORGANISM_A_ID ORGANISM_B_ID SOURCE
PSEN1 CTNNB1 Affinity Capture-Western 9852041 9606 9606 BIOGRID
PSEN1 CTNNB1 Affinity Capture-Western 10341227 9606 9606 BIOGRID
PSEN1 NCSTN Affinity Capture-Western 14572442 9606 9606 BIOGRID
PSEN1 PSENEN Affinity Capture-Western 14572442 9606 9606 BIOGRID
PSEN1 APH1A Affinity Capture-Western 14572442 9606 9606 BIOGRID
PSEN1 PSENEN Affinity Capture-Western 12639958 9606 9606 BIOGRID
PSEN1 GFAP Two-hybrid 12058025 9606 9606 BIOGRID
PSEN1 GFAP Reconstituted Complex 12058025 9606 9606 BIOGRID
PSEN1 FLNB Two-hybrid 9437013 9606 9606 BIOGRID
PSEN1 ICAM5 Affinity Capture-Western 11719200 9606 9606 BIOGRID
PSEN1 ICAM5 Two-hybrid 11719200 9606 9606 BIOGRID
PSEN1 ICAM5 Reconstituted Complex 11719200 9606 9606 BIOGRID
PSEN1 PKP4 Affinity Capture-Western 10092585 9606 9606 BIOGRID
PSEN1 PKP4 Reconstituted Complex 10092585 9606 9606 BIOGRID
PSEN1 PKP4 Two-hybrid 10092585 9606 9606 BIOGRID
PSEN1 FBXW7 Affinity Capture-Western 12354302 9606 9606 BIOGRID
PSEN1 APH1A Affinity Capture-Western 12471034 9606 9606 BIOGRID
PSEN1 PSEN2 Affinity Capture-Western 12471034 9606 9606 BIOGRID
PSEN1 NCSTN Affinity Capture-Western 12471034 9606 9606 BIOGRID
PSEN1 BCL2 Two-hybrid 10521466 9606 9606 BIOGRID
PSEN1 CTNNA1 Affinity Capture-Western 10635315 9606 9606 BIOGRID
PSEN1 NOTCH1 Affinity Capture-Western 10077672 9606 9606 BIOGRID
PSEN1 BCL2L1 Two-hybrid 10446169 9606 9606 BIOGRID
PSEN1 HERPUD1 Affinity Capture-Western 11799129 9606 9606 BIOGRID
PSEN1 CTNND1 Two-hybrid 10208590 9606 9606 BIOGRID
PSEN1 CTNND1 Reconstituted Complex 10208590 9606 9606 BIOGRID
PSEN1 CTNND1 Affinity Capture-Western 10208590 9606 9606 BIOGRID
PSEN1 MAPT Co-fractionation 9689133 9606 9606 BIOGRID
PSEN1 KCNIP4 Two-hybrid 11847232 9606 9606 BIOGRID
PSEN1 CIB1 Two-hybrid 10366599 9606 9606 BIOGRID
PSEN1 PSEN1 Two-hybrid 12535650 9606 9606 BIOGRID
PSEN1 YME1L1 Two-hybrid 12214059 9606 9606 BIOGRID
PSEN1 CTNNB1 Affinity Capture-Western 17360711 9606 9606 BIOGRID
PSEN1 PSMB1 Two-hybrid 10527805 9606 9606 BIOGRID
PSEN1 PSMA5 Two-hybrid 10527805 9606 9606 BIOGRID
PSEN1 PSMB1 Affinity Capture-Western 10527805 9606 9606 BIOGRID
PSEN1 PSMA5 Affinity Capture-Western 10527805 9606 9606 BIOGRID
PSEN1 UBQLN1 FRET 16815845 9606 9606 BIOGRID
PSEN1 TRAF6 Affinity Capture-Western 18996842 9606 9606 BIOGRID
PSEN1 IRAK2 Affinity Capture-Western 18996842 9606 9606 BIOGRID
PSEN1 HERPUD1 Affinity Capture-Western 14550564 9606 9606 BIOGRID
PSEN1 APOE Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 PSEN2 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 CDC37 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 RAB3A Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 PRAM1 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 GCDH Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 KANK2 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 CDK5 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 AP1M2 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 CYP2C18 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 CYP2C8 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 FBXL12 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 NOS3 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 PDCD4 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 PRDX2 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 RAD23A Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 RHEB Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 STAMBPL1 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 EPB41L3 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 ACTN1 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 EFHD1 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 GAPDH Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 RMDN3 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 ST13 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 ENSA Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 CFL1 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 UMPS Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 OXCT1 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 FGF13 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 HMGB1 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 ITSN2 Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 SCN1A Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 TUBA1B Two-hybrid 21163940 9606 9606 BIOGRID
PSEN1 ECSIT Affinity Capture-Western 21163940 9606 9606 BIOGRID
PSEN1 ST13 Affinity Capture-Western 21163940 9606 9606 BIOGRID
PSEN1 ECSIT Reconstituted Complex 21163940 9606 9606 BIOGRID
PSEN1 NCSTN Affinity Capture-Western 15474363 9606 9606 BIOGRID
PSEN1 PSENEN Affinity Capture-Western 15474363 9606 9606 BIOGRID
PSEN1 APH1A Affinity Capture-Western 15474363 9606 9606 BIOGRID
PSEN1 PSEN1 Affinity Capture-Western 15474363 9606 9606 BIOGRID
PSEN1 PSEN2 Affinity Capture-Western 15474363 9606 9606 BIOGRID
PSEN1 TRAF6 Affinity Capture-Western 23707529 9606 9606 BIOGRID
PSEN1 TDP2 Two-hybrid 21988832 9606 9606 BIOGRID
PSEN1 ETFA Two-hybrid 10527805 9606 9606 BIOGRID
PSEN1 ERLIN2 Affinity Capture-MS 22771797 9606 9606 BIOGRID
PSEN1 ERLIN2 Affinity Capture-Western 22771797 9606 9606 BIOGRID
PSEN1 TGFBR1 Affinity Capture-Western 24399296 9606 9606 BIOGRID
PSEN1 TRAF6 Affinity Capture-Western 24399296 9606 9606 BIOGRID
PSEN1 TGFBR1 Co-localization 24399296 9606 9606 BIOGRID
PSEN1 UBC Co-localization 24399296 9606 9606 BIOGRID
PSEN1 NCSTN Co-fractionation 17911105 9606 9606 BIOGRID
PSEN1 NCSTN Affinity Capture-Western 17911105 9606 9606 BIOGRID
PSEN1 CDH2 Affinity Capture-Western 20696212 9606 9606 BIOGRID
PSEN1 NOTCH1 FRET 28351972 9606 9606 BIOGRID
PSEN1 APP FRET 28351972 9606 9606 BIOGRID
PSEN1 NCSTN FRET 28351972 9606 9606 BIOGRID
PSEN1 PSEN1 Co-fractionation 9452432 9606 9606 BIOGRID
PSEN1 PSEN1 Affinity Capture-Western 9452432 9606 9606 BIOGRID
PSEN1 FKBP8 Two-hybrid 15905180 9606 9606 BIOGRID
PSEN1 FKBP8 Affinity Capture-Western 15905180 9606 9606 BIOGRID
PSEN1 BCL2 Affinity Capture-Western 15905180 9606 9606 BIOGRID
PSEN1 GSK3B Affinity Capture-Western 11193155 9606 9606 BIOGRID
PSEN1 CTNNB1 Affinity Capture-Western 11193155 9606 9606 BIOGRID
PSEN1 TXNRD2 Co-fractionation 31536960 9606 9606 BIOGRID
PSEN1 CHCHD4 Co-fractionation 31536960 9606 9606 BIOGRID
PSEN1 MCFD2 Co-fractionation 31536960 9606 9606 BIOGRID
PSEN1 PGD Co-fractionation 31536960 9606 9606 BIOGRID
PSEN1 TMEM30A Co-fractionation 31536960 9606 9606 BIOGRID
PSEN1 TOMM22 Co-fractionation 31536960 9606 9606 BIOGRID
PSEN1 ARF4 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 ARL1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 ATP2A2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 BCAP31 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 CDKN2A Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 CHMP1A Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 EMC8 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 CYP51A1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 DDX20 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 DEGS1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 DNAJB11 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 DNAJC7 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 EIF4G1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 ERLIN2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 FADS1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 FAF2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 ESYT1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 HSD17B12 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 EMC1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 MAGEB2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 MLEC Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PCBP2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PGRMC1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSMA2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSMB5 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSMC2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSMC3 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PTPLAD1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 RDH11 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 RHBDD2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 RPL38 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 RPN2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 SAR1A Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 SCD Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 SLC1A5 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 SOAT1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 SRPRB Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 SSR1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 SSR3 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 SSR4 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 STT3A Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 TBL3 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 TMCO1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 TMED10 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 TMEM33 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 TMEM43 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 EMC2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 ZW10 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 BAG6 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 CNOT7 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 DNAJA1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 DNAJA2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 GLB1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSMA5 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSMA6 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSMA7 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSMB2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSMD14 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 RANGAP1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 BAG2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 HSPA5 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 HSPA8 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 HSPB1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 MLF1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 DHCR24 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 DNAJB12 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 FADS2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 DDOST Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSEN1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSMA4 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSMB1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSMD2 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 SKP1 Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 UBC Affinity Capture-MS 25959826 9606 9606 BIOGRID
PSEN1 PSMD2 Affinity Capture-Western 25959826 9606 9606 BIOGRID
PSEN1 DHCR24 Affinity Capture-Western 25959826 9606 9606 BIOGRID
PSEN1 SKP1 Affinity Capture-Western 25959826 9606 9606 BIOGRID
PSEN1 SLC10A6 Two-hybrid 32296183 9606 9606 BIOGRID
PSEN1 PSENEN Two-hybrid 32296183 9606 9606 BIOGRID
 Annotation of PSEN1
 TCGA cancer survival map of PSEN1


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.
Reset Add The plot axis-x order will follow the list.


Calculate the hazards ratio based on Cox PH Model.
We use log2(TPM + 1) for log-scale.
All Add
Reset The plot is based on the datasets of list.


 Disease information of  PSEN1