TcoF overview
TcoF: SIAH2
GeneID: 6622
Name: E3 ubiquitin-protein ligase
Ensembl: ENSG00000181788
Species: Human
Class: class 2
Family: Others
Disease: 1
Go term: 31
Pathway: 6
Hallmark: 3
Super Enhancer:

chr3:150439327-150490005 chr3:150441405-150479334 chr3:150445639-150490259 chr3:150442346-150519407 chr3:150455024-150482907 chr3:150477230-150482447 chr3:150464405-150482174 chr3:150442522-150482850 chr3:150442374-150482396 chr3:150442803-150483070 chr3:150450935-150489423 chr3:150453545-150486115 chr3:150442634-150480763 chr3:150439001-150490137 chr3:150441559-150482444 chr3:150455427-150482651 chr3:150444643-150492339 chr3:150476748-150482435 chr3:150461862-150482895 chr3:150455847-150482999 chr3:150439337-150489445 chr3:150450912-150459709 chr3:150478079-150489417 chr3:150442336-150460811 chr3:150454332-150480730 chr3:150442233-150482650 chr3:150439362-150489282 chr3:150450843-150485132 chr3:150442754-150482157 chr3:150442552-150503160 chr3:150454520-150482585 chr3:150440177-150482556 chr3:150454915-150482891 chr3:150455143-150504000 chr3:150454365-150482948 chr3:150439170-150486021 chr3:150439145-150485593 chr3:150439145-150485593 chr3:150439170-150486021 chr3:150445439-150482946 chr3:150442374-150482103 chr3:150455651-150484659 chr3:150454726-150485517 chr3:150453690-150482800 chr3:150439203-150482863 chr3:150456469-150485651 chr3:150478988-150482406 chr3:150451106-150483177 chr3:150455044-150485328 chr3:150454969-150485189 chr3:150445530-150492269 chr3:150446270-150489900 chr3:150445427-150490234 chr3:150430280-150485064 chr3:150439235-150489713 chr3:150439212-150483261 chr3:150440179-150480064 chr3:150439310-150483282

Enhancer:

chr3:150344950-150345440 chr3:150454300-150456630 chr3:150384800-150386600 chr3:150398720-150400000 chr3:150383960-150384570 chr3:150286260-150286980 chr3:150804810-150807060 chr3:150452650-150454120 chr3:150299840-150300980 chr3:150301050-150301630 chr3:150129100-150131400 chr3:150133260-150133790 chr3:150492680-150493780 chr3:150093690-150095080 chr3:149956620-149956720 chr3:149986110-149987610 chr3:149988640-149989620 chr3:149996050-149997320 chr3:150013860-150014210 chr3:150016820-150018080 chr3:150018300-150019620 chr3:150019830-150020510 chr3:150026360-150027580 chr3:150031230-150033270 chr3:150033500-150033950 chr3:150034190-150036360 chr3:150036640-150038680 chr3:150081950-150082360 chr3:150082870-150084010 chr3:150108920-150109420 chr3:150215340-150216930 chr3:150324980-150326670 chr3:150438090-150440470 chr3:150441500-150442310 chr3:150442690-150444290 chr3:150445720-150445890 chr3:150446340-150448520 chr3:150010260-150012390 chr3:150277120-150279550 chr3:150273570-150275690 chr3:150248200-150250540 chr3:150053080-150054150 chr3:150059430-150060260 chr3:150139740-150140500 chr3:150164490-150166540 chr3:150166620-150168060 chr3:150168200-150169560 chr3:150183690-150185180 chr3:150235220-150237150 chr3:150237350-150238430 chr3:150450420-150452250 chr3:150461770-150463300 chr3:150463540-150464900 chr3:150465030-150465420 chr3:150465990-150466510 chr3:150466950-150467350 chr3:149823640-149826130 chr3:150146830-150148700 chr3:150348240-150350640

Promoter:

chr3:150458912-150481264

 ChIP-seq based regulatory details of SIAH2
Sample ID Experiment target Biosample type Biosample term name GSM ID Tissue type Source
 Downstream target genes of SIAH2
 Protein-protein interaction of SIAH2
OFFICIAL_SYMBOL_A OFFICIAL_SYMBOL_B EXPERIMENTAL_SYSTEM PUBMED_ID ORGANISM_A_ID ORGANISM_B_ID SOURCE
SIAH2 RBBP8 Reconstituted Complex 14654780 9606 9606 BIOGRID
SIAH2 VAV1 Reconstituted Complex 10207103 9606 9606 BIOGRID
SIAH2 VAV1 Affinity Capture-Western 10207103 9606 9606 BIOGRID
SIAH2 AKAP1 Affinity Capture-Western 18323779 9606 9606 BIOGRID
SIAH2 PIAS1 Two-hybrid 17533377 9606 9606 BIOGRID
SIAH2 PIAS2 Two-hybrid 17533377 9606 9606 BIOGRID
SIAH2 UBE2I Two-hybrid 17533377 9606 9606 BIOGRID
SIAH2 PIAS1 Reconstituted Complex 17533377 9606 9606 BIOGRID
SIAH2 PIAS3 Reconstituted Complex 17533377 9606 9606 BIOGRID
SIAH2 PIAS1 Biochemical Activity 17533377 9606 9606 BIOGRID
SIAH2 SNCAIP Biochemical Activity 16174773 9606 9606 BIOGRID
SIAH2 DLST Reconstituted Complex 15466852 9606 9606 BIOGRID
SIAH2 DLST Affinity Capture-Western 15466852 9606 9606 BIOGRID
SIAH2 SNCA Biochemical Activity 15064394 9606 9606 BIOGRID
SIAH2 PLCE1 Affinity Capture-Western 17998205 9606 9606 BIOGRID
SIAH2 USP13 Affinity Capture-Western 21659512 9606 9606 BIOGRID
SIAH2 USP13 Reconstituted Complex 21659512 9606 9606 BIOGRID
SIAH2 HIPK2 Affinity Capture-Western 19043406 9606 9606 BIOGRID
SIAH2 HDAC3 Affinity Capture-Western 20691163 9606 9606 BIOGRID
SIAH2 SNCA Biochemical Activity 18070888 9606 9606 BIOGRID
SIAH2 SNCA Affinity Capture-Western 18070888 9606 9606 BIOGRID
SIAH2 SNCA Biochemical Activity 19224863 9606 9606 BIOGRID
SIAH2 PSMD4 Biochemical Activity 19240029 9606 9606 BIOGRID
SIAH2 TINF2 Affinity Capture-Western 22064479 9606 9606 BIOGRID
SIAH2 TINF2 Biochemical Activity 22064479 9606 9606 BIOGRID
SIAH2 TINF2 Two-hybrid 22064479 9606 9606 BIOGRID
SIAH2 SNCA Biochemical Activity 22065755 9606 9606 BIOGRID
SIAH2 USP19 Affinity Capture-Western 22128162 9606 9606 BIOGRID
SIAH2 CEBPD Affinity Capture-Western 22037769 9606 9606 BIOGRID
SIAH2 UBE2I Two-hybrid 9334332 9606 9606 BIOGRID
SIAH2 SH3RF1 Two-hybrid 21586138 9606 9606 BIOGRID
SIAH2 PPP1R12A Two-hybrid 19744480 9606 9606 BIOGRID
SIAH2 PPP1R12A Affinity Capture-Western 19744480 9606 9606 BIOGRID
SIAH2 EGLN3 Reconstituted Complex 15210114 9606 9606 BIOGRID
SIAH2 PSMD4 Biochemical Activity 22350919 9606 9606 BIOGRID
SIAH2 DYRK2 Affinity Capture-Western 22878263 9606 9606 BIOGRID
SIAH2 DYRK2 Reconstituted Complex 22878263 9606 9606 BIOGRID
SIAH2 PML Affinity Capture-Western 14645235 9606 9606 BIOGRID
SIAH2 TPX2 Two-hybrid 17716627 9606 9606 BIOGRID
SIAH2 TPX2 Affinity Capture-Western 17716627 9606 9606 BIOGRID
SIAH2 UBE2D2 Reconstituted Complex 19224863 9606 9606 BIOGRID
SIAH2 UBE2D2 Reconstituted Complex 16174773 9606 9606 BIOGRID
SIAH2 UBE2D1 Reconstituted Complex 18070888 9606 9606 BIOGRID
SIAH2 UBE2D2 Reconstituted Complex 22065755 9606 9606 BIOGRID
SIAH2 KAT5 Affinity Capture-Western 23044042 9606 9606 BIOGRID
SIAH2 KAT2B Affinity Capture-Western 23044042 9606 9606 BIOGRID
SIAH2 TNK2 Affinity Capture-Western 23208506 9606 9606 BIOGRID
SIAH2 USP19 Affinity Capture-Western 23500468 9606 9606 BIOGRID
SIAH2 PPP1R13B Affinity Capture-Western 23644657 9606 9606 BIOGRID
SIAH2 TP53BP2 Affinity Capture-Western 23644657 9606 9606 BIOGRID
SIAH2 TP53BP2 Biochemical Activity 23644657 9606 9606 BIOGRID
SIAH2 NFE2L2 Affinity Capture-Western 23645672 9606 9606 BIOGRID
SIAH2 SIAH2 Biochemical Activity 23891150 9606 9606 BIOGRID
SIAH2 UBE2D3 Reconstituted Complex 23891150 9606 9606 BIOGRID
SIAH2 STAT3 Two-hybrid 21988832 9606 9606 BIOGRID
SIAH2 UBE2I Two-hybrid 21988832 9606 9606 BIOGRID
SIAH2 UBE2L6 Affinity Capture-Western 11786535 9606 9606 BIOGRID
SIAH2 EGLN3 Affinity Capture-Western 25202994 9606 9606 BIOGRID
SIAH2 EGLN3 Reconstituted Complex 25202994 9606 9606 BIOGRID
SIAH2 HIPK2 Affinity Capture-Western 25313037 9606 9606 BIOGRID
SIAH2 XAF1 Affinity Capture-Western 25313037 9606 9606 BIOGRID
SIAH2 XAF1 Phenotypic Suppression 25313037 9606 9606 BIOGRID
SIAH2 UBE2D1 Reconstituted Complex 19240029 9606 9606 BIOGRID
SIAH2 AKR1C3 Affinity Capture-Western 26160177 9606 9606 BIOGRID
SIAH2 AKR1C3 Reconstituted Complex 26160177 9606 9606 BIOGRID
SIAH2 SIAH2 Biochemical Activity 26160177 9606 9606 BIOGRID
SIAH2 UBE2D1 Reconstituted Complex 26160177 9606 9606 BIOGRID
SIAH2 CHEK2 Affinity Capture-Western 26751770 9606 9606 BIOGRID
SIAH2 CHEK2 Reconstituted Complex 26751770 9606 9606 BIOGRID
SIAH2 CHEK2 Biochemical Activity 26751770 9606 9606 BIOGRID
SIAH2 EAF2 Affinity Capture-Western 27058417 9606 9606 BIOGRID
SIAH2 SIAH1 Two-hybrid 16899216 9606 9606 BIOGRID
SIAH2 SIAH2 Affinity Capture-Western 16899216 9606 9606 BIOGRID
SIAH2 SIAH1 Affinity Capture-Western 16899216 9606 9606 BIOGRID
SIAH2 ZYX Reconstituted Complex 27030211 9606 9606 BIOGRID
SIAH2 ZYX Affinity Capture-Western 27030211 9606 9606 BIOGRID
SIAH2 LATS2 Affinity Capture-Western 27030211 9606 9606 BIOGRID
SIAH2 PLK3 Affinity Capture-Western 28515325 9606 9606 BIOGRID
SIAH2 SIAH2 Biochemical Activity 23695783 9606 9606 BIOGRID
SIAH2 UBE2D2 Reconstituted Complex 23695783 9606 9606 BIOGRID
SIAH2 UBE2D3 Reconstituted Complex 23695783 9606 9606 BIOGRID
SIAH2 UBE2N Reconstituted Complex 23695783 9606 9606 BIOGRID
SIAH2 UBE2V2 Reconstituted Complex 23695783 9606 9606 BIOGRID
SIAH2 FLNC Affinity Capture-MS 30063986 9606 9606 BIOGRID
SIAH2 TES Affinity Capture-MS 30063986 9606 9606 BIOGRID
SIAH2 EP300 Affinity Capture-Western 30063986 9606 9606 BIOGRID
SIAH2 FLNC Affinity Capture-Western 30063986 9606 9606 BIOGRID
SIAH2 TES Affinity Capture-Western 30063986 9606 9606 BIOGRID
SIAH2 PIWIL2 Affinity Capture-Western 29555935 9606 9606 BIOGRID
SIAH2 NRF1 Reconstituted Complex 30833558 9606 9606 BIOGRID
SIAH2 NRF1 Affinity Capture-Western 30833558 9606 9606 BIOGRID
SIAH2 NRF1 Biochemical Activity 30833558 9606 9606 BIOGRID
SIAH2 UBE2D3 Reconstituted Complex 30833558 9606 9606 BIOGRID
SIAH2 HMOX1 Affinity Capture-Western 32042051 9606 9606 BIOGRID
SIAH2 DLST Biochemical Activity 30771432 9606 9606 BIOGRID
SIAH2 Akap1 Reconstituted Complex 18323779 9606 10090 BIOGRID
SIAH2 Akap1 Affinity Capture-Western 18323779 9606 10090 BIOGRID
 Annotation of SIAH2
 TCGA cancer survival map of SIAH2


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.
Reset Add The plot axis-x order will follow the list.


Calculate the hazards ratio based on Cox PH Model.
We use log2(TPM + 1) for log-scale.
All Add
Reset The plot is based on the datasets of list.


 Disease information of  SIAH2