TcoF overview
| TcoF: | SIRT3 | |
| GeneID: | 6498 | |
| Name: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | |
| Ensembl: | ENSG00000142082 | |
| Species: | Human | |
| Class: | NA | |
| Family: | Sirtuin | |
| Disease: | 5 | |
| Go term: | 25 | |
| Pathway: | 4 | |
| Hallmark: | 1 | |
| Super Enhancer: |
-- |
|
| Enhancer: |
chr11:319990-320560 chr11:394520-396600 chr11:406540-406840 chr11:406990-407060 chr11:407160-407420 chr11:612220-612550 chr11:624260-624550 chr11:654050-654610 chr11:278600-279320 chr11:279610-279830 chr11:279870-280080 chr11:289240-289800 chr11:308440-308990 chr11:314360-314920 chr11:396690-396810 chr11:397450-397530 chr11:407570-407810 chr11:500660-502060 chr11:567850-568080 chr11:613600-613780 chr11:250870-251540 chr11:250500-250800 chr11:290080-290380 chr11:555500-555730 chr11:606600-607060 chr11:605720-606440 chr11:290600-290670 chr11:291110-291970 chr11:555110-555300 chr11:585060-587250 chr11:640710-643200 chr11:612800-612990 chr11:613120-613200 chr11:613870-613950 chr11:614040-614170 chr11:614400-614470 chr11:422400-422900 chr11:614540-614790 chr11:369960-372100 chr11:225180-227020 chr11:505000-506610 chr11:406060-406340 chr11:621000-621070 chr11:216720-217950 chr11:593280-595340 chr11:408890-409860 chr11:621900-624210 chr11:222740-224070 chr11:295730-298200 chr11:352440-354470 chr11:456330-458200 chr11:587460-588920 chr11:664860-666770 chr11:726750-726900 chr11:763940-764280 chr11:764430-764810 chr11:788660-790020 chr11:819910-821630 chr11:836840-837240 chr11:837360-837450 chr11:837620-837820 chr11:861620-862540 chr11:862740-864430 chr11:872800-873820 chr11:875430-877660 chr11:908650-910770 chr11:930750-932420 chr11:944560-946850 chr11:980370-981190 chr11:981430-981640 chr11:1059910-1061680 chr11:637590-639430 chr11:818960-819570 chr11:834590-836060 chr11:965820-967470 chr11:1146740-1148800 chr11:317440-319670 chr11:359180-360030 chr11:397660-398390 chr11:404140-404230 chr11:404910-405710 chr11:407960-408070 chr11:408210-408690 chr11:410030-412000 chr11:412600-414820 chr11:552700-553960 chr11:611080-611630 chr11:615010-615090 chr11:621250-621340 chr11:621460-621540 chr11:624730-624810 chr11:645310-646780 chr11:647400-647850 chr11:657000-659010 chr11:706290-708730 chr11:709610-710420 chr11:710490-711980 chr11:712150-714560 chr11:719470-720020 chr11:720220-720590 chr11:720750-720820 chr11:720910-721060 chr11:721210-721280 chr11:721350-721560 chr11:721690-721900 chr11:721990-722090 chr11:722170-722400 chr11:722810-723240 chr11:724830-725720 chr11:725850-726090 chr11:726170-726300 chr11:726480-726610 chr11:732700-734690 chr11:763520-763740 chr11:803590-804090 chr11:804460-804940 chr11:812630-812750 chr11:821860-821950 chr11:822020-822390 chr11:822610-823260 chr11:833030-834520 chr11:836150-836250 chr11:836440-836760 chr11:869960-870120 chr11:936270-937020 chr11:937730-938440 chr11:939450-941440 chr11:942100-943800 chr11:951600-953380 chr11:953460-953800 chr11:954040-954410 chr11:954710-956400 chr11:985580-986780 chr11:986950-987430 chr11:995000-995420 chr11:995490-996510 chr11:1077920-1078090 chr11:1081810-1082280 chr11:1142230-1143380 chr11:1144610-1146620 chr11:1150310-1151750 chr11:1153700-1154540 chr11:654650-656310 chr11:220040-221940 chr11:460290-462470 chr11:458640-460180 chr11:241360-242290 chr11:531160-532240 chr11:765020-767220 chr11:811820-812530 chr11:812880-813900 chr11:864510-865510 chr11:865830-865910 chr11:298710-299300 chr11:439600-441920 chr11:855190-857420 chr11:866000-866560 chr11:867120-867850 chr11:974700-977090 chr11:1013630-1013890 chr11:373520-373740 chr11:373830-374750 chr11:471260-471840 chr11:772520-773520 chr11:315270-317190 chr11:528230-530490 |
|
| Promoter: |
chr11:215030-236931 |
ChIP-seq based regulatory details of SIRT3
| Sample ID | Experiment target | Biosample type | Biosample term name | GSM ID | Tissue type | Source |
|---|---|---|---|---|---|---|
| TcoF_00_30718 | SIRT3 | cell line | U2OS | GSM1006653 | Bone | ChIP-Atlas |
| TcoF_00_30719 | SIRT3 | cell line | U2OS | GSM1006655 | Bone | ChIP-Atlas |
| TcoF_00_30720 | SIRT3 | cell line | U2OS | GSM1006657 | Bone | ChIP-Atlas |
| TcoF_00_30721 | SIRT3 | cell line | U2OS | GSM1006658 | Bone | ChIP-Atlas |
Downstream target genes of SIRT3
Upstream regulatory details of SIRT3
Protein-protein interaction of SIRT3
| OFFICIAL_SYMBOL_A | OFFICIAL_SYMBOL_B | EXPERIMENTAL_SYSTEM | PUBMED_ID | ORGANISM_A_ID | ORGANISM_B_ID | SOURCE |
|---|---|---|---|---|---|---|
| SIRT3 | FOXO3 | Affinity Capture-Western | 18781224 | 9606 | 9606 | BIOGRID |
| SIRT3 | XRCC6 | Affinity Capture-Western | 18710944 | 9606 | 9606 | BIOGRID |
| SIRT3 | XRCC6 | Reconstituted Complex | 18710944 | 9606 | 9606 | BIOGRID |
| SIRT3 | XRCC6 | Biochemical Activity | 18710944 | 9606 | 9606 | BIOGRID |
| SIRT3 | ATP5A1 | Affinity Capture-Western | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | HSPA4 | Affinity Capture-Western | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | ATP5A1 | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | ATP5B | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | HSPD1 | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | NCAPD2 | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | GRN | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | HSPA5 | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | HSPA1L | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | HSP90B1 | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | CMYA5 | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | PGAP1 | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | RIF1 | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | HSPA9 | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | SBF1 | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | HERC2 | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | TTF2 | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | SNTB1 | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | UQCRH | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | UGDH | Affinity Capture-MS | 19343720 | 9606 | 9606 | BIOGRID |
| SIRT3 | HSPD1 | Affinity Capture-Western | 21840382 | 9606 | 9606 | BIOGRID |
| SIRT3 | HSPD1 | Reconstituted Complex | 21840382 | 9606 | 9606 | BIOGRID |
| SIRT3 | SKP2 | Affinity Capture-Western | 23045395 | 9606 | 9606 | BIOGRID |
| SIRT3 | SKP2 | Affinity Capture-Western | 22770219 | 9606 | 9606 | BIOGRID |
| SIRT3 | DMC1 | Affinity Capture-MS | 26186194 | 9606 | 9606 | BIOGRID |
| SIRT3 | MDM2 | Biochemical Activity | 28196907 | 9606 | 9606 | BIOGRID |
| SIRT3 | PDHA1 | Biochemical Activity | 24486017 | 9606 | 9606 | BIOGRID |
| SIRT3 | PDP1 | Biochemical Activity | 24486017 | 9606 | 9606 | BIOGRID |
| SIRT3 | PDHA1 | Affinity Capture-Western | 24486017 | 9606 | 9606 | BIOGRID |
| SIRT3 | PDP1 | Affinity Capture-Western | 24486017 | 9606 | 9606 | BIOGRID |
| SIRT3 | SDHA | Affinity Capture-MS | 28514442 | 9606 | 9606 | BIOGRID |
| SIRT3 | HSPD1 | Affinity Capture-MS | 28514442 | 9606 | 9606 | BIOGRID |
| SIRT3 | DMC1 | Affinity Capture-MS | 28514442 | 9606 | 9606 | BIOGRID |
| SIRT3 | TMEM25 | Affinity Capture-MS | 28514442 | 9606 | 9606 | BIOGRID |
| SIRT3 | ALDH2 | Biochemical Activity | 28248093 | 9606 | 9606 | BIOGRID |
| SIRT3 | HIST1H3A | Affinity Capture-Western | 29136592 | 9606 | 9606 | BIOGRID |
| SIRT3 | HIST1H3A | Biochemical Activity | 29136592 | 9606 | 9606 | BIOGRID |
| SIRT3 | ACADVL | Biochemical Activity | 25811481 | 9606 | 9606 | BIOGRID |
| SIRT3 | GLUD1 | Affinity Capture-MS | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | ACADVL | Affinity Capture-MS | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | HSDL2 | Affinity Capture-MS | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | RUVBL1 | Affinity Capture-MS | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | ATP5A1 | Affinity Capture-MS | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | HIST1H4A | Affinity Capture-MS | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | PDHB | Affinity Capture-MS | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | CS | Affinity Capture-MS | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | PYCR1 | Affinity Capture-MS | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | ETHE1 | Affinity Capture-MS | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | HSD17B10 | Affinity Capture-MS | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | ACAD9 | Affinity Capture-MS | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | PDK2 | Affinity Capture-MS | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | PYCR1 | Affinity Capture-Western | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | PYCR1 | Biochemical Activity | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | PYCR1 | Reconstituted Complex | 31108370 | 9606 | 9606 | BIOGRID |
| SIRT3 | tat | Biochemical Activity | 15719057 | 9606 | 11676 | BIOGRID |
Annotation of SIRT3
TCGA cancer survival map of SIRT3
Expression of SIRT3
Disease information of SIRT3