| Sirt1 |
axon |
GO:0030424 |
| Sirt1 |
chromatin |
GO:0000785 |
| Sirt1 |
chromatin silencing complex |
GO:0005677 |
| Sirt1 |
cytoplasm |
GO:0005737 |
| Sirt1 |
cytosol |
GO:0005829 |
| Sirt1 |
ESC/E(Z) complex |
GO:0035098 |
| Sirt1 |
growth cone |
GO:0030426 |
| Sirt1 |
mitochondrion |
GO:0005739 |
| Sirt1 |
nuclear chromatin |
GO:0000790 |
| Sirt1 |
nuclear envelope |
GO:0005635 |
| Sirt1 |
nuclear euchromatin |
GO:0005719 |
| Sirt1 |
nuclear heterochromatin |
GO:0005720 |
| Sirt1 |
nuclear inner membrane |
GO:0005637 |
| Sirt1 |
nucleolus |
GO:0005730 |
| Sirt1 |
nucleoplasm |
GO:0005654 |
| Sirt1 |
nucleus |
GO:0005634 |
| Sirt1 |
PML body |
GO:0016605 |
| Sirt1 |
rDNA heterochromatin |
GO:0033553 |
| Sirt1 |
bHLH transcription factor binding |
GO:0043425 |
| Sirt1 |
deacetylase activity |
GO:0019213 |
| Sirt1 |
enzyme binding |
GO:0019899 |
| Sirt1 |
histone binding |
GO:0042393 |
| Sirt1 |
histone deacetylase activity |
GO:0004407 |
| Sirt1 |
HLH domain binding |
GO:0043398 |
| Sirt1 |
identical protein binding |
GO:0042802 |
| Sirt1 |
keratin filament binding |
GO:1990254 |
| Sirt1 |
metal ion binding |
GO:0046872 |
| Sirt1 |
mitogen-activated protein kinase binding |
GO:0051019 |
| Sirt1 |
NAD+ binding |
GO:0070403 |
| Sirt1 |
NAD-dependent histone deacetylase activity |
GO:0017136 |
| Sirt1 |
NAD-dependent histone deacetylase activity (H3-K9 specific) |
GO:0046969 |
| Sirt1 |
NAD-dependent protein deacetylase activity |
GO:0034979 |
| Sirt1 |
nuclear hormone receptor binding |
GO:0035257 |
| Sirt1 |
p53 binding |
GO:0002039 |
| Sirt1 |
protein C-terminus binding |
GO:0008022 |
| Sirt1 |
protein deacetylase activity |
GO:0033558 |
| Sirt1 |
protein domain specific binding |
GO:0019904 |
| Sirt1 |
protein kinase B binding |
GO:0043422 |
| Sirt1 |
protein-propionyllysine depropionylase activity |
GO:0106231 |
| Sirt1 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO:0000978 |
| Sirt1 |
transcription coactivator activity |
GO:0003713 |
| Sirt1 |
transcription corepressor activity |
GO:0003714 |
| Sirt1 |
transcription factor binding |
GO:0008134 |
| Sirt1 |
angiogenesis |
GO:0001525 |
| Sirt1 |
behavioral response to starvation |
GO:0042595 |
| Sirt1 |
cellular glucose homeostasis |
GO:0001678 |
| Sirt1 |
cellular response to amyloid-beta |
GO:1904646 |
| Sirt1 |
cellular response to DNA damage stimulus |
GO:0006974 |
| Sirt1 |
cellular response to hydrogen peroxide |
GO:0070301 |
| Sirt1 |
cellular response to hypoxia |
GO:0071456 |
| Sirt1 |
cellular response to ionizing radiation |
GO:0071479 |
| Sirt1 |
cellular response to leukemia inhibitory factor |
GO:1990830 |
| Sirt1 |
cellular response to starvation |
GO:0009267 |
| Sirt1 |
cellular response to tumor necrosis factor |
GO:0071356 |
| Sirt1 |
cellular triglyceride homeostasis |
GO:0035356 |
| Sirt1 |
cholesterol homeostasis |
GO:0042632 |
| Sirt1 |
chromatin organization |
GO:0006325 |
| Sirt1 |
circadian regulation of gene expression |
GO:0032922 |
| Sirt1 |
circadian rhythm |
GO:0007623 |
| Sirt1 |
DNA synthesis involved in DNA repair |
GO:0000731 |
| Sirt1 |
energy homeostasis |
GO:0097009 |
| Sirt1 |
fatty acid homeostasis |
GO:0055089 |
| Sirt1 |
heterochromatin assembly |
GO:0031507 |
| Sirt1 |
heterochromatin maintenance |
GO:0070829 |
| Sirt1 |
histone deacetylation |
GO:0016575 |
| Sirt1 |
histone H3 deacetylation |
GO:0070932 |
| Sirt1 |
intrinsic apoptotic signaling pathway in response to DNA damage |
GO:0008630 |
| Sirt1 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
GO:0042771 |
| Sirt1 |
leptin-mediated signaling pathway |
GO:0033210 |
| Sirt1 |
macrophage cytokine production |
GO:0010934 |
| Sirt1 |
macrophage differentiation |
GO:0030225 |
| Sirt1 |
muscle organ development |
GO:0007517 |
| Sirt1 |
negative regulation of androgen receptor signaling pathway |
GO:0060766 |
| Sirt1 |
negative regulation of apoptotic process |
GO:0043066 |
| Sirt1 |
negative regulation of cAMP-dependent protein kinase activity |
GO:2000480 |
| Sirt1 |
negative regulation of cardiac muscle cell apoptotic process |
GO:0010667 |
| Sirt1 |
negative regulation of cell death |
GO:0060548 |
| Sirt1 |
negative regulation of cell growth |
GO:0030308 |
| Sirt1 |
negative regulation of cellular response to testosterone stimulus |
GO:2000655 |
| Sirt1 |
negative regulation of cellular senescence |
GO:2000773 |
| Sirt1 |
negative regulation of DNA binding |
GO:0043392 |
| Sirt1 |
negative regulation of DNA damage response, signal transduction by p53 class mediator |
GO:0043518 |
| Sirt1 |
negative regulation of DNA-binding transcription factor activity |
GO:0043433 |
| Sirt1 |
negative regulation of fat cell differentiation |
GO:0045599 |
| Sirt1 |
negative regulation of fibroblast apoptotic process |
GO:2000270 |
| Sirt1 |
negative regulation of gene expression |
GO:0010629 |
| Sirt1 |
negative regulation of growth hormone secretion |
GO:0060125 |
| Sirt1 |
negative regulation of helicase activity |
GO:0051097 |
| Sirt1 |
negative regulation of histone H3-K14 acetylation |
GO:0071441 |
| Sirt1 |
negative regulation of histone H3-K9 trimethylation |
GO:1900113 |
| Sirt1 |
negative regulation of histone H4-K16 acetylation |
GO:2000619 |
| Sirt1 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
GO:0043124 |
| Sirt1 |
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
GO:1902166 |
| Sirt1 |
negative regulation of neuron apoptotic process |
GO:0043524 |
| Sirt1 |
negative regulation of neuron death |
GO:1901215 |
| Sirt1 |
negative regulation of NF-kappaB transcription factor activity |
GO:0032088 |
| Sirt1 |
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
GO:1902176 |
| Sirt1 |
negative regulation of peptidyl-lysine acetylation |
GO:2000757 |
| Sirt1 |
negative regulation of phosphorylation |
GO:0042326 |
| Sirt1 |
negative regulation of prostaglandin biosynthetic process |
GO:0031393 |
| Sirt1 |
negative regulation of protein acetylation |
GO:1901984 |
| Sirt1 |
negative regulation of protein kinase B signaling |
GO:0051898 |
| Sirt1 |
negative regulation of protein localization to nucleus |
GO:1900181 |
| Sirt1 |
negative regulation of reactive oxygen species biosynthetic process |
GO:1903427 |
| Sirt1 |
negative regulation of TOR signaling |
GO:0032007 |
| Sirt1 |
negative regulation of transcription by RNA polymerase II |
GO:0000122 |
| Sirt1 |
negative regulation of transcription, DNA-templated |
GO:0045892 |
| Sirt1 |
negative regulation of transforming growth factor beta receptor signaling pathway |
GO:0030512 |
| Sirt1 |
negative regulation of tumor necrosis factor production |
GO:0032720 |
| Sirt1 |
ovulation from ovarian follicle |
GO:0001542 |
| Sirt1 |
peptidyl-lysine acetylation |
GO:0018394 |
| Sirt1 |
peptidyl-lysine deacetylation |
GO:0034983 |
| Sirt1 |
positive regulation of adaptive immune response |
GO:0002821 |
| Sirt1 |
positive regulation of adipose tissue development |
GO:1904179 |
| Sirt1 |
positive regulation of angiogenesis |
GO:0045766 |
| Sirt1 |
positive regulation of apoptotic process |
GO:0043065 |
| Sirt1 |
positive regulation of blood vessel diameter |
GO:0097755 |
| Sirt1 |
positive regulation of blood vessel endothelial cell migration |
GO:0043536 |
| Sirt1 |
positive regulation of cAMP-dependent protein kinase activity |
GO:2000481 |
| Sirt1 |
positive regulation of cell growth involved in cardiac muscle cell development |
GO:0061051 |
| Sirt1 |
positive regulation of cell population proliferation |
GO:0008284 |
| Sirt1 |
positive regulation of cellular senescence |
GO:2000774 |
| Sirt1 |
positive regulation of cholesterol efflux |
GO:0010875 |
| Sirt1 |
positive regulation of chromatin silencing |
GO:0031937 |
| Sirt1 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
GO:0043280 |
| Sirt1 |
positive regulation of DNA repair |
GO:0045739 |
| Sirt1 |
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
GO:1902237 |
| Sirt1 |
positive regulation of endothelial cell proliferation |
GO:0001938 |
| Sirt1 |
positive regulation of gluconeogenesis |
GO:0045722 |
| Sirt1 |
positive regulation of heart rate |
GO:0010460 |
| Sirt1 |
positive regulation of histone H3-K9 methylation |
GO:0051574 |
| Sirt1 |
positive regulation of insulin receptor signaling pathway |
GO:0046628 |
| Sirt1 |
positive regulation of insulin secretion involved in cellular response to glucose stimulus |
GO:0035774 |
| Sirt1 |
positive regulation of macroautophagy |
GO:0016239 |
| Sirt1 |
positive regulation of macrophage apoptotic process |
GO:2000111 |
| Sirt1 |
positive regulation of MHC class II biosynthetic process |
GO:0045348 |
| Sirt1 |
positive regulation of neuron projection development |
GO:0010976 |
| Sirt1 |
positive regulation of phosphatidylinositol 3-kinase signaling |
GO:0014068 |
| Sirt1 |
positive regulation of protein deacetylation |
GO:0090312 |
| Sirt1 |
positive regulation of protein phosphorylation |
GO:0001934 |
| Sirt1 |
positive regulation of skeletal muscle cell proliferation |
GO:0014858 |
| Sirt1 |
positive regulation of smooth muscle cell differentiation |
GO:0051152 |
| Sirt1 |
positive regulation of thyroid-stimulating hormone secretion |
GO:2000614 |
| Sirt1 |
positive regulation of transcription by RNA polymerase II |
GO:0045944 |
| Sirt1 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
GO:0043161 |
| Sirt1 |
protein deacetylation |
GO:0006476 |
| Sirt1 |
protein depropionylation |
GO:0106230 |
| Sirt1 |
protein destabilization |
GO:0031648 |
| Sirt1 |
protein ubiquitination |
GO:0016567 |
| Sirt1 |
pyrimidine dimer repair by nucleotide-excision repair |
GO:0000720 |
| Sirt1 |
rDNA heterochromatin assembly |
GO:0000183 |
| Sirt1 |
regulation of apoptotic process |
GO:0042981 |
| Sirt1 |
regulation of bile acid biosynthetic process |
GO:0070857 |
| Sirt1 |
regulation of brown fat cell differentiation |
GO:0090335 |
| Sirt1 |
regulation of cell population proliferation |
GO:0042127 |
| Sirt1 |
regulation of endodeoxyribonuclease activity |
GO:0032071 |
| Sirt1 |
regulation of glucose metabolic process |
GO:0010906 |
| Sirt1 |
regulation of lipid storage |
GO:0010883 |
| Sirt1 |
regulation of mitotic cell cycle |
GO:0007346 |
| Sirt1 |
regulation of peroxisome proliferator activated receptor signaling pathway |
GO:0035358 |
| Sirt1 |
regulation of protein serine/threonine kinase activity |
GO:0071900 |
| Sirt1 |
regulation of smooth muscle cell apoptotic process |
GO:0034391 |
| Sirt1 |
response to ethanol |
GO:0045471 |
| Sirt1 |
response to hydrogen peroxide |
GO:0042542 |
| Sirt1 |
response to insulin |
GO:0032868 |
| Sirt1 |
response to leptin |
GO:0044321 |
| Sirt1 |
response to oxidative stress |
GO:0006979 |
| Sirt1 |
single strand break repair |
GO:0000012 |
| Sirt1 |
spermatogenesis |
GO:0007283 |
| Sirt1 |
stress-induced premature senescence |
GO:0090400 |
| Sirt1 |
transforming growth factor beta receptor signaling pathway |
GO:0007179 |
| Sirt1 |
triglyceride mobilization |
GO:0006642 |
| Sirt1 |
UV-damage excision repair |
GO:0070914 |
| Sirt1 |
white fat cell differentiation |
GO:0050872 |