| Cdk7 |
Formation of the closed pre-initiation complex |
IEA |
R-MMU-109639 |
| Cdk7 |
Addition of nucleotides between position +11 and +30 |
IEA |
R-MMU-111264 |
| Cdk7 |
Recruitment of elongation factors to form elongation complex |
IEA |
R-MMU-112379 |
| Cdk7 |
Hypophosphorylation of RNA Pol II CTD by FCP1P protein |
IEA |
R-MMU-112383 |
| Cdk7 |
Addition of nucleotides leads to transcript elongation |
IEA |
R-MMU-112385 |
| Cdk7 |
Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex |
IEA |
R-MMU-113430 |
| Cdk7 |
CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes |
IEA |
R-MMU-170076 |
| Cdk7 |
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes |
IEA |
R-MMU-170087 |
| Cdk7 |
CAK-mediated phosphorylation of Cyclin A:Cdk2 |
IEA |
R-MMU-187949 |
| Cdk7 |
CAK-mediated phosphorylation of Cyclin E:Cdk2 |
IEA |
R-MMU-188350 |
| Cdk7 |
Recruitment of XPA and release of CAK |
IEA |
R-MMU-5689861 |
| Cdk7 |
TFIIH binds GG-NER site to form a verification complex |
IEA |
R-MMU-5691000 |
| Cdk7 |
RNA Pol II initiates transcription from damaged DNA template |
IEA |
R-MMU-6781818 |
| Cdk7 |
Active RNA Pol II complex transcribes lesion-containing DNA template |
IEA |
R-MMU-6781824 |
| Cdk7 |
ERCC8 (CSA) binds stalled RNA Pol II |
IEA |
R-MMU-6781833 |
| Cdk7 |
ERCC6 binds stalled RNA Pol II |
IEA |
R-MMU-6781840 |
| Cdk7 |
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II |
IEA |
R-MMU-6781867 |
| Cdk7 |
Assembly of the pre-incision complex in TC-NER |
IEA |
R-MMU-6782004 |
| Cdk7 |
UVSSA:USP7 deubiquitinates ERCC6 |
IEA |
R-MMU-6782069 |
| Cdk7 |
ERCC2-facilitated RNA Pol II backtracking in TC-NER |
IEA |
R-MMU-6782131 |
| Cdk7 |
ERCC5 and RPA bind TC-NER site |
IEA |
R-MMU-6782138 |
| Cdk7 |
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER |
IEA |
R-MMU-6782141 |
| Cdk7 |
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER |
IEA |
R-MMU-6782204 |
| Cdk7 |
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER |
IEA |
R-MMU-6782208 |
| Cdk7 |
DNA polymerases delta, epsilon or kappa bind the TC-NER site |
IEA |
R-MMU-6782211 |
| Cdk7 |
3' incision by ERCC5 (XPG) in TC-NER |
IEA |
R-MMU-6782224 |
| Cdk7 |
Ligation of newly synthesized repair patch to incised DNA in TC-NER |
IEA |
R-MMU-6782227 |
| Cdk7 |
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes |
IEA |
R-MMU-6797606 |
| Cdk7 |
CCNK:CDK12 binds RNA Pol II at DNA repair genes |
IEA |
R-MMU-6797616 |
| Cdk7 |
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter |
IEA |
R-MMU-6810233 |
| Cdk7 |
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene |
IEA |
R-MMU-6810234 |
| Cdk7 |
RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain |
IEA |
R-MMU-6810235 |
| Cdk7 |
RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) |
IEA |
R-MMU-6810238 |
| Cdk7 |
Pre-snRNA transcript initiation, Integrator binding, LEC binding |
IEA |
R-MMU-6814549 |
| Cdk7 |
Integrator complex processes the 3' end of snRNA |
IEA |
R-MMU-6814555 |
| Cdk7 |
Pre-snRNA is elongated and capped with 7-methylguanosine |
IEA |
R-MMU-6814559 |
| Cdk7 |
CBCAP complex binds 7-methylguanosine cap of snRNA |
IEA |
R-MMU-6814885 |
| Cdk7 |
Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter |
IEA |
R-MMU-73758 |
| Cdk7 |
Loss of Rrn3 from RNA Polymerase I promoter escape complex |
IEA |
R-MMU-73769 |
| Cdk7 |
Abortive initiation after formation of the first phosphodiester bond |
IEA |
R-MMU-73946 |
| Cdk7 |
Elongation of pre-rRNA transcript |
IEA |
R-MMU-74986 |
| Cdk7 |
PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box |
IEA |
R-MMU-74993 |
| Cdk7 |
Addition of the third nucleotide on the nascent transcript |
IEA |
R-MMU-75850 |
| Cdk7 |
Abortive Initiation Before Second Transition |
IEA |
R-MMU-75856 |
| Cdk7 |
NTP Binds Active Site of RNA Polymerase II |
IEA |
R-MMU-75861 |
| Cdk7 |
Fall Back to Closed Pre-initiation Complex |
IEA |
R-MMU-75862 |
| Cdk7 |
Newly Formed Phosphodiester Bond Stabilized and PPi Released |
IEA |
R-MMU-75864 |
| Cdk7 |
Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP |
IEA |
R-MMU-75866 |
| Cdk7 |
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition |
IEA |
R-MMU-75869 |
| Cdk7 |
Addition of Nucleotides 5 through 9 on the growing Transcript |
IEA |
R-MMU-75873 |
| Cdk7 |
Abortive Initiation After Second Transition |
IEA |
R-MMU-75891 |
| Cdk7 |
RNA Polymerase II Promoter Opening: First Transition |
IEA |
R-MMU-75949 |
| Cdk7 |
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition |
IEA |
R-MMU-76576 |
| Cdk7 |
Activation of GT |
IEA |
R-MMU-77068 |
| Cdk7 |
RNA Polymerase II CTD (phosphorylated) binds to CE |
IEA |
R-MMU-77069 |
| Cdk7 |
Phosphorylation (Ser5) of RNA pol II CTD |
IEA |
R-MMU-77071 |
| Cdk7 |
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) |
IEA |
R-MMU-77073 |
| Cdk7 |
Capping complex formation |
IEA |
R-MMU-77077 |
| Cdk7 |
Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme |
IEA |
R-MMU-77078 |
| Cdk7 |
Formation of the CE:GMP intermediate complex |
IEA |
R-MMU-77081 |
| Cdk7 |
Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA |
IEA |
R-MMU-77083 |
| Cdk7 |
Dissociation of transcript with 5'-GMP from GT |
IEA |
R-MMU-77085 |
| Cdk7 |
Methylation of GMP-cap by RNA Methyltransferase |
IEA |
R-MMU-77090 |
| Cdk7 |
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 |
IEA |
R-MMU-8942836 |
| Cdk7 |
RUNX1 binds the core TAL1 complex |
IEA |
R-MMU-8956568 |
| Cdk7 |
Unwinding of DNA for the Nascent Transcript: Second Transition |
IEA |
R-MMU-9613494 |
| Cdk7 |
Unwinding DNA for the nascent transcript |
IEA |
R-MMU-9613497 |
| Cdk7 |
ERCC3-facilitated RNA Pol II backtracking in TC-NER |
IEA |
R-MMU-9684118 |