| Smurf2 |
SMURF2 ubiquitinates SMAD2 |
IEA |
R-MMU-173542 |
| Smurf2 |
SMAD7 binds to SMURF2 |
IEA |
R-MMU-178208 |
| Smurf2 |
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 |
IEA |
R-MMU-201445 |
| Smurf2 |
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated |
IEA |
R-MMU-201821 |
| Smurf2 |
SMURF2 binds SMAD2 |
IEA |
R-MMU-2176445 |
| Smurf2 |
SMURF2 binds SMAD3 phosphorylated in the linker region |
IEA |
R-MMU-2179274 |
| Smurf2 |
SMURF2 monoubiquitinates SMAD3 |
IEA |
R-MMU-2179276 |
| Smurf2 |
SMURF1/2 ubiquitinates PRICKLE1 |
IEA |
R-MMU-4608852 |
| Smurf2 |
SMURF1/2 are recruited to the DVL2:PARD6A complex |
IEA |
R-MMU-4608854 |
| Smurf2 |
AXIN is ubiquitinated by SMURF2 |
IEA |
R-MMU-4641129 |
| Smurf2 |
SMURF2 binds AXIN |
IEA |
R-MMU-4641134 |
| Smurf2 |
Ubiquitinated AXIN is degraded by the proteasome |
IEA |
R-MMU-4641256 |
| Smurf2 |
Smurf1/2 bind Ptch1 |
TAS |
R-MMU-5632642 |
| Smurf2 |
Smurf1/2 ubiquitinates Ptch1 |
TAS |
R-MMU-5632644 |
| Smurf2 |
SMURF1/2 dissociates from ub-PTCH1 |
IEA |
R-MMU-5635865 |
| Smurf2 |
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 |
IEA |
R-MMU-6781764 |
| Smurf2 |
SMURFs ubiquitinate RUNX3 |
IEA |
R-MMU-8952419 |
| Smurf2 |
Transfer of Ub from E2 to substrate and release of E2 |
IEA |
R-MMU-983140 |
| Smurf2 |
Release of E3 from polyubiquitinated substrate |
IEA |
R-MMU-983147 |
| Smurf2 |
Polyubiquitination of substrate |
IEA |
R-MMU-983156 |
| Smurf2 |
Interaction of E3 with substrate and E2-Ub complex |
IEA |
R-MMU-983157 |