| Traf6 |
TRAF6 binds MEKK1 |
IEA |
R-MMU-166869 |
| Traf6 |
Activated TAK1 mediates phosphorylation of the IKK Complex |
IEA |
R-MMU-168184 |
| Traf6 |
K63-linked ubiquitination of RIP1 bound to the activated TLR complex |
IEA |
R-MMU-168915 |
| Traf6 |
IKK-beta is recruited |
IEA |
R-MMU-193641 |
| Traf6 |
MYD88 dissociates |
IEA |
R-MMU-193665 |
| Traf6 |
TRAF6 binds to p75NTR:NRIF |
IEA |
R-MMU-193669 |
| Traf6 |
p62 recruits an atypical PKC |
IEA |
R-MMU-193684 |
| Traf6 |
p62 is recruited and forms a complex with TRAF6 |
IEA |
R-MMU-193694 |
| Traf6 |
IRAK interacts with TRAF6 |
IEA |
R-MMU-193695 |
| Traf6 |
p75NTR ICD signals to NF-kB |
IEA |
R-MMU-193700 |
| Traf6 |
IKKbeta is activated |
IEA |
R-MMU-193703 |
| Traf6 |
IKKbeta phosphorylates IkB causing NF-kB to dissociate |
IEA |
R-MMU-193705 |
| Traf6 |
Auto-ubiquitination of TRAF6 |
IEA |
R-MMU-202453 |
| Traf6 |
Auto-ubiquitination of TRAF6 |
IEA |
R-MMU-202453 |
| Traf6 |
Translocation of TRAF6 to CBM complex |
IEA |
R-MMU-202472 |
| Traf6 |
Activation of IKK complex |
IEA |
R-MMU-202500 |
| Traf6 |
Activation of TAK1-TAB2 complex |
IEA |
R-MMU-202510 |
| Traf6 |
Ubiquitination of NEMO by TRAF6 |
IEA |
R-MMU-202534 |
| Traf6 |
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 |
IEA |
R-MMU-205112 |
| Traf6 |
TRAF6 polyubiquitinates NRIF |
IEA |
R-MMU-205118 |
| Traf6 |
TRAF6 is auto-ubiquitinated |
IEA |
R-MMU-209566 |
| Traf6 |
TRAF6 is auto-ubiquitinated |
IEA |
R-MMU-209566 |
| Traf6 |
PI3K phosphorylates PIP2 to PIP3 |
IEA |
R-MMU-2316434 |
| Traf6 |
Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 |
IEA |
R-MMU-2730861 |
| Traf6 |
Recruitment of TRAF6 to CBM complex by binding to MALT1 |
IEA |
R-MMU-2730864 |
| Traf6 |
Phosphorylation of IKK-beta by TAK1 |
IEA |
R-MMU-2730876 |
| Traf6 |
Activation of TAK1 complex bound to pUb-TRAF6 |
IEA |
R-MMU-2730900 |
| Traf6 |
Oligomerization of TRAF6 |
IEA |
R-MMU-2730903 |
| Traf6 |
Auto-ubiquitination of TRAF6 |
IEA |
R-MMU-2730904 |
| Traf6 |
Auto-ubiquitination of TRAF6 |
IEA |
R-MMU-2730904 |
| Traf6 |
Hyperphosphorylated IRAK1 associates with TRAF6 |
IEA |
R-MMU-446862 |
| Traf6 |
Polyubiquitinated TRAF6 binds the TAK1 complex |
IEA |
R-MMU-446870 |
| Traf6 |
TRAF6 is K63 poly-ubiquitinated |
IEA |
R-MMU-446877 |
| Traf6 |
TRAF6 is K63 poly-ubiquitinated |
IEA |
R-MMU-446877 |
| Traf6 |
TRAF6 binding leads to IRAK1:TRAF6 release |
IEA |
R-MMU-446894 |
| Traf6 |
IRAK1 induces oligomerisation of TRAF6 |
IEA |
R-MMU-450173 |
| Traf6 |
TAK1 is activated within the TAK1 complex |
IEA |
R-MMU-450187 |
| Traf6 |
Activated TAK1 phosphorylates MKK4/MKK7 |
IEA |
R-MMU-450337 |
| Traf6 |
activated human TAK1 phosphorylates MKK3/MKK6 |
IEA |
R-MMU-450346 |
| Traf6 |
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation |
IEA |
R-MMU-450358 |
| Traf6 |
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation |
IEA |
R-MMU-450358 |
| Traf6 |
p62:MEKK3 binds to TRAF6 |
IEA |
R-MMU-507719 |
| Traf6 |
K63polyUb-TAK1 autophosphorylates |
IEA |
R-MMU-5607732 |
| Traf6 |
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta |
IEA |
R-MMU-5607742 |
| Traf6 |
TRAF6 binds MALT1 oligomers |
IEA |
R-MMU-5607747 |
| Traf6 |
TRAF6 oligomerizes |
IEA |
R-MMU-5607751 |
| Traf6 |
TRAF6 oligomer autoubiquitinates |
IEA |
R-MMU-5607756 |
| Traf6 |
TRAF6 oligomer autoubiquitinates |
IEA |
R-MMU-5607756 |
| Traf6 |
K63polyUb-TRAF6 ubiquitinates TAK1 |
IEA |
R-MMU-5607757 |
| Traf6 |
TRIKA2 binds K63polyUb-TRAF6 oligomer |
IEA |
R-MMU-5607759 |
| Traf6 |
OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA |
IEA |
R-MMU-5690843 |
| Traf6 |
OTUD7B,TNFAIP3 deubiquitinate TRAF6 |
IEA |
R-MMU-5690870 |
| Traf6 |
OTUD7B,TNFAIP3 deubiquitinate TRAF6 |
IEA |
R-MMU-5690870 |
| Traf6 |
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG |
IEA |
R-MMU-5696627 |
| Traf6 |
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG |
IEA |
R-MMU-5696627 |
| Traf6 |
RIP2 is K63 polyubiquitinated |
IEA |
R-MMU-688137 |
| Traf6 |
RIP2 induces K63-linked ubiquitination of NEMO |
IEA |
R-MMU-741386 |
| Traf6 |
USP4 deubiquitinate TRAF2,TRAF6 |
IEA |
R-MMU-8869456 |
| Traf6 |
USP4 deubiquitinate TRAF2,TRAF6 |
IEA |
R-MMU-8869456 |
| Traf6 |
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 |
IEA |
R-MMU-8869506 |
| Traf6 |
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 |
IEA |
R-MMU-8869506 |
| Traf6 |
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb |
IEA |
R-MMU-8948015 |
| Traf6 |
UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 |
IEA |
R-MMU-8948018 |
| Traf6 |
Interaction of MEKK1 with TRAF6 |
TAS |
R-MMU-933534 |
| Traf6 |
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 |
IEA |
R-MMU-936942 |
| Traf6 |
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 |
IEA |
R-MMU-936942 |
| Traf6 |
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex |
IEA |
R-MMU-936947 |
| Traf6 |
Activation of TAK1 complex bound to activated TLR4 complex |
IEA |
R-MMU-936951 |
| Traf6 |
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex |
IEA |
R-MMU-936952 |
| Traf6 |
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex |
IEA |
R-MMU-936952 |
| Traf6 |
Activated TRAF6:p-IRAK2 interacts with TAK1 complex |
IEA |
R-MMU-936960 |
| Traf6 |
IRAK2 induces TRAF6 oligomerization |
IEA |
R-MMU-936963 |
| Traf6 |
IRAK2 induces TRAF6 oligomerization |
IEA |
R-MMU-936963 |
| Traf6 |
Activated TLR4:TICAM1 recruits TRAF6 |
IEA |
R-MMU-936985 |
| Traf6 |
Activated TRAF6 synthesizes unanchored polyubiquitin chains |
IEA |
R-MMU-936986 |
| Traf6 |
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 |
IEA |
R-MMU-936991 |
| Traf6 |
NEMO subunit of IKK complex binds to activated IRAK1 |
IEA |
R-MMU-937032 |
| Traf6 |
IRAK1 phosphorylates Pellino |
IEA |
R-MMU-937034 |
| Traf6 |
Pellino binds hp-IRAK1:TRAF6 |
IEA |
R-MMU-937044 |
| Traf6 |
Pellino ubiquitinates hp-IRAK1 |
IEA |
R-MMU-937050 |
| Traf6 |
Pellino ubiquitinates hp-IRAK1 |
IEA |
R-MMU-937050 |
| Traf6 |
Phosphorylated TAK1 leaves activated TLR receptor complex |
IEA |
R-MMU-937075 |
| Traf6 |
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation |
IEA |
R-MMU-9645394 |
| Traf6 |
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) |
IEA |
R-MMU-9645406 |
| Traf6 |
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer |
IEA |
R-MMU-9645414 |
| Traf6 |
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer |
IEA |
R-MMU-9645414 |
| Traf6 |
Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex |
IEA |
R-MMU-9645442 |
| Traf6 |
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex |
IEA |
R-MMU-9645501 |
| Traf6 |
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 |
IEA |
R-MMU-9645520 |
| Traf6 |
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation |
IEA |
R-MMU-975097 |
| Traf6 |
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation |
IEA |
R-MMU-975103 |
| Traf6 |
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. |
IEA |
R-MMU-975119 |
| Traf6 |
Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
|
IEA |
R-MMU-975122 |
| Traf6 |
IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation |
IEA |
R-MMU-975139 |
| Traf6 |
Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation |
IEA |
R-MMU-975142 |
| Traf6 |
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane |
IEA |
R-MMU-975147 |
| Traf6 |
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane |
IEA |
R-MMU-975147 |
| Traf6 |
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments |
IEA |
R-MMU-975185 |
| Traf6 |
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments |
IEA |
R-MMU-975185 |