| Vhl |
Proteasome proteolyzes ub-HIF-alpha |
IEA |
R-MMU-1234159 |
| Vhl |
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha |
IEA |
R-MMU-1234163 |
| Vhl |
Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha |
IEA |
R-MMU-1234169 |
| Vhl |
Nuclear VBC complex ubiquitinylates HIF-alpha |
IEA |
R-MMU-1234172 |
| Vhl |
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A |
IEA |
R-MMU-1234173 |
| Vhl |
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol |
IEA |
R-MMU-1234175 |
| Vhl |
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol |
IEA |
R-MMU-1234175 |
| Vhl |
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A |
IEA |
R-MMU-1234177 |
| Vhl |
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha |
IEA |
R-MMU-1234183 |
| Vhl |
PIAS4 SUMOylates VHL with SUMO1 |
IEA |
R-MMU-4551721 |
| Vhl |
PIAS4 SUMOylates VHL with SUMO1 |
IEA |
R-MMU-4551721 |
| Vhl |
CAND1 binds cytosolic CRL E3 ubiquitin ligases |
IEA |
R-MMU-8955241 |
| Vhl |
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes |
IEA |
R-MMU-8955289 |
| Vhl |
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes |
IEA |
R-MMU-8956040 |
| Vhl |
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 |
IEA |
R-MMU-8956099 |
| Vhl |
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha |
IEA |
R-MMU-8956103 |
| Vhl |
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha |
IEA |
R-MMU-8956106 |
| Vhl |
Transfer of Ub from E2 to substrate and release of E2 |
IEA |
R-MMU-983140 |
| Vhl |
Release of E3 from polyubiquitinated substrate |
IEA |
R-MMU-983147 |
| Vhl |
Polyubiquitination of substrate |
IEA |
R-MMU-983156 |
| Vhl |
Interaction of E3 with substrate and E2-Ub complex |
IEA |
R-MMU-983157 |