TcoF overview
| TcoF: | Sirt1 | |
| GeneID: | 93759 | |
| Name: | NAD-dependent protein deacetylase sirtuin-1 | |
| Ensembl: | ENSMUSG00000020063 | |
| Species: | Mouse | |
| Class: | class HC | |
| Family: | Sirtuin | |
| Disease: | 2 | |
| Go-trem: | 174 | |
| Pathway: | 6 | |
| Super Enhancer: | chr10:63326677-63327574 chr10:63327621-63328173 chr10:63346790-63368639 chr10:63307303-63321610 chr10:63347346-63367591 |
|
| Enhancer: |
chr10:62708870-62711300 chr10:62892920-62893550 chr10:62848680-62849310 chr10:62485730-62486460 chr10:62706910-62707430 chr10:62706910-62707540 chr10:62892920-62893600 chr10:62849520-62849830 chr10:62485360-62486460 chr10:62706910-62707580 chr10:62849000-62849310 chr10:62706910-62708160 chr10:62708870-62708970 chr10:62484400-62486460 chr10:62892920-62893230 chr10:62849520-62850030 chr10:62551610-62552900 chr10:62892920-62894000 chr10:63114940-63117350 chr10:62848350-62849310 chr10:62484340-62486460 chr10:62528150-62528530 chr10:62551920-62552900 chr10:62563350-62563670 chr10:62892920-62893860 chr10:62848490-62849310 chr10:62484520-62486460 chr10:62585180-62586010 chr10:62892920-62893540 chr10:62849040-62849310 chr10:62485650-62486460 chr10:62892920-62893300 chr10:62482670-62486460 chr10:62639170-62640480 chr10:62485680-62486460 chr10:62519580-62520380 chr10:62551990-62552900 chr10:62623380-62624350 chr10:62644360-62646400 chr10:62892920-62893280 chr10:62849520-62849620 chr10:62485200-62486460 chr10:62738830-62740890 chr10:62892920-62893360 chr10:62645160-62646000 chr10:62551650-62552900 chr10:62563350-62563630 chr10:62639170-62643760 chr10:62644400-62646300 chr10:62892920-62893370 chr10:62849520-62849800 chr10:62892920-62893520 chr10:62848780-62849310 chr10:62485320-62486460 chr10:62706910-62707500 chr10:62483780-62486460 chr10:62487480-62487920 chr10:62892920-62893650 chr10:62485900-62486460 chr10:62628260-62628900 chr10:62709780-62710600 chr10:62873330-62874380 chr10:62878340-62879080 chr10:62483690-62486460 chr10:62590840-62591640 chr10:62918740-62920250 chr10:62920410-62922690 chr10:63004340-63005820 chr10:62917560-62920250 chr10:62920410-62922310 chr10:62484820-62486460 chr10:62528630-62529270 chr10:62641700-62643030 chr10:62663780-62666460 chr10:62693620-62694010 chr10:62892920-62893940 chr10:62920410-62921980 chr10:62942880-62943940 chr10:63004400-63004990 chr10:62848870-62849310 chr10:62640210-62640630 chr10:62552510-62552900 chr10:62706910-62707460 chr10:62633740-62651450 chr10:62798620-62799720 chr10:62745430-62745920 chr10:62776260-62776890 chr10:62799570-62799720 chr10:62859260-62859980 chr10:62860120-62860440 chr10:62892920-62893490 chr10:62849520-62849900 chr10:62892920-62893400 chr10:62848800-62849310 chr10:62485380-62486460 chr10:62706910-62707470 chr10:62892920-62893020 chr10:63004430-63005000 chr10:62892920-62893110 chr10:63004410-63005670 chr10:62849520-62849700 chr10:62734770-62736190 chr10:62736420-62737080 chr10:62849520-62849760 chr10:62485330-62486460 chr10:62848860-62849310 chr10:62709920-62710700 chr10:62485510-62486460 chr10:62710220-62710590 chr10:62878010-62878840 chr10:62485690-62486460 chr10:62590520-62591760 chr10:62892920-62893640 chr10:63003280-63007480 chr10:63033570-63036710 chr10:62894720-62896620 chr10:62902170-62904080 chr10:62849520-62849990 chr10:62485420-62486460 chr10:62706910-62707480 chr10:62484500-62486460 chr10:62892920-62893350 chr10:62849520-62849930 chr10:62706910-62707290 chr10:62706910-62707320 chr10:62628040-62629600 chr10:62709250-62711130 chr10:62878570-62879450 chr10:62892920-62893120 chr10:62849520-62850010 chr10:62892920-62893190 chr10:62849520-62850580 chr10:62485490-62486460 chr10:62892920-62893220 chr10:62849520-62849610 chr10:62482270-62486460 chr10:62892920-62893210 chr10:62484450-62486460 chr10:62706910-62707380 chr10:62845260-62845670 chr10:62706910-62707510 chr10:62849060-62849310 chr10:62892920-62893310 chr10:62551950-62552640 chr10:62645080-62646230 chr10:62892920-62893430 chr10:62642200-62642620 chr10:62892920-62893100 chr10:62849520-62849680 |
|
| Promoter: |
chr10:63337035-63341035 |
ChIP-seq based regulatory details of Sirt1
| Sample ID | Experiment target | Biosample term name | Cell type | Tissue type | Source |
|---|---|---|---|---|---|
| TcoF_01_20315 | Sirt1 | None | None | Bone Marrow | Cistrome |
| TcoF_01_20314 | Sirt1 | None | None | Bone Marrow | Cistrome |
| TcoF_01_20312 | Sirt1 | None | Satellite Cells | None | Cistrome |
| TcoF_01_20311 | Sirt1 | None | Satellite Cells | None | Cistrome |
| TcoF_01_20310 | Sirt1 | None | Satellite Cells | None | Cistrome |
| TcoF_01_20309 | Sirt1 | None | Satellite Cells | None | Cistrome |
| TcoF_01_20036 | Sirt1 | None | None | Cerebellum | Cistrome |
| TcoF_01_20035 | Sirt1 | None | None | Cerebellum | Cistrome |
Downstream target genes of Sirt1
Protein-protein interaction of Sirt1
| OFFICIAL_SYMBOL_A | OFFICIAL_SYMBOL_B | EXPERIMENTAL_SYSTEM | PUBMED_ID | ORGANISM_A_ID | ORGANISM_B_ID | SOURCE |
|---|---|---|---|---|---|---|
| Sirt1 | Zfp236 | Two-hybrid | 20211142 | 10090 | 10090 | BIOGRID |
| Sirt1 | Rela | Affinity Capture-Western | 21454709 | 10090 | 10090 | BIOGRID |
| Sirt1 | Ep300 | Affinity Capture-Western | 21454709 | 10090 | 10090 | BIOGRID |
| Sirt1 | Rela | Co-localization | 21454709 | 10090 | 10090 | BIOGRID |
| Sirt1 | Esrra | Affinity Capture-Western | 20484414 | 10090 | 10090 | BIOGRID |
| Sirt1 | Nr0b2 | Affinity Capture-Western | 20375098 | 10090 | 10090 | BIOGRID |
| Sirt1 | Hnf1a | Affinity Capture-Western | 21176092 | 10090 | 10090 | BIOGRID |
| Sirt1 | Pax3 | Affinity Capture-Western | 21169561 | 10090 | 10090 | BIOGRID |
| Sirt1 | Hes1 | Affinity Capture-RNA | 21169561 | 10090 | 10090 | BIOGRID |
| Sirt1 | Neurog2 | Affinity Capture-RNA | 21169561 | 10090 | 10090 | BIOGRID |
| Sirt1 | Nr0b2 | Affinity Capture-RNA | 21081708 | 10090 | 10090 | BIOGRID |
| Sirt1 | Acaca | Affinity Capture-Western | 19343720 | 10090 | 10090 | BIOGRID |
| Sirt1 | Ppargc1a | Reconstituted Complex | 15744310 | 10090 | 10090 | BIOGRID |
| Sirt1 | Ppargc1a | Affinity Capture-Western | 15744310 | 10090 | 10090 | BIOGRID |
| Sirt1 | Ppargc1a | Biochemical Activity | 15744310 | 10090 | 10090 | BIOGRID |
| Sirt1 | Hnf4a | Affinity Capture-Western | 15744310 | 10090 | 10090 | BIOGRID |
| Sirt1 | Kat8 | Affinity Capture-Western | 22586264 | 10090 | 10090 | BIOGRID |
| Sirt1 | Kat5 | Affinity Capture-Western | 22586264 | 10090 | 10090 | BIOGRID |
| Sirt1 | Mecp2 | Affinity Capture-Western | 22677942 | 10090 | 10090 | BIOGRID |
| Sirt1 | Ncor1 | Affinity Capture-Western | 15175761 | 10090 | 10090 | BIOGRID |
| Sirt1 | Ncor1 | Reconstituted Complex | 15175761 | 10090 | 10090 | BIOGRID |
| Sirt1 | Ncor2 | Reconstituted Complex | 15175761 | 10090 | 10090 | BIOGRID |
| Sirt1 | Clock | Affinity Capture-Western | 18662546 | 10090 | 10090 | BIOGRID |
| Sirt1 | Arntl | Affinity Capture-Western | 18662546 | 10090 | 10090 | BIOGRID |
| Sirt1 | Per2 | Affinity Capture-Western | 18662546 | 10090 | 10090 | BIOGRID |
| Sirt1 | Per2 | Biochemical Activity | 18662546 | 10090 | 10090 | BIOGRID |
| Sirt1 | IRS2 | Affinity Capture-Western | 17901049 | 10090 | 9606 | BIOGRID |
| Sirt1 | TP53 | Reconstituted Complex | 19680552 | 10090 | 9606 | BIOGRID |
| Sirt1 | TP53 | Biochemical Activity | 19680552 | 10090 | 9606 | BIOGRID |
| Sirt1 | Dyrk3 | Two-hybrid | 20167603 | 10090 | 10090 | BIOGRID |
| Sirt1 | DYRK1A | Reconstituted Complex | 20167603 | 10090 | 9606 | BIOGRID |
| Sirt1 | DYRK3 | Reconstituted Complex | 20167603 | 10090 | 9606 | BIOGRID |
| Sirt1 | Dyrk3 | Affinity Capture-Western | 20167603 | 10090 | 10090 | BIOGRID |
| Sirt1 | Dyrk1a | Affinity Capture-Western | 20167603 | 10090 | 10090 | BIOGRID |
| Sirt1 | TP53 | Biochemical Activity | 20167603 | 10090 | 9606 | BIOGRID |
| Sirt1 | TP53 | Affinity Capture-Western | 20167603 | 10090 | 9606 | BIOGRID |
| Sirt1 | TP53 | Reconstituted Complex | 20167603 | 10090 | 9606 | BIOGRID |
| Sirt1 | Foxo1 | Affinity Capture-Western | 22514318 | 10090 | 10090 | BIOGRID |
| Sirt1 | Ndn | Affinity Capture-Western | 22514318 | 10090 | 10090 | BIOGRID |
| Sirt1 | Cbx5 | Affinity Capture-Western | 28059589 | 10090 | 10090 | BIOGRID |
| Sirt1 | Cbx3 | Affinity Capture-Western | 28059589 | 10090 | 10090 | BIOGRID |
| Sirt1 | Rnf219 | Affinity Capture-Western | 32220064 | 10090 | 10090 | BIOGRID |
Annotation of Sirt1
Expression of Sirt1
Disease information of Sirt1