TcoF overview
TcoF: CHEK1
GeneID: 9318
Name: Serine/threonine-protein kinase Chk1
Ensembl: ENSG00000149554
Species: Human
Class: class 2
Family: Others
Disease: 8
Go term: 38
Pathway: 25
Hallmark: 4
Super Enhancer:

chr11:125494569-125497218

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Enhancer:

chr11:125105010-125106880 chr11:125132580-125134280 chr11:125462810-125463530 chr11:125496540-125496640 chr11:125365510-125366010 chr11:125496730-125497500 chr11:125514160-125514400 chr11:125514540-125515400 chr11:125184100-125186200 chr11:125240040-125242190 chr11:125333470-125335770 chr11:125321090-125322220 chr11:125463620-125465770 chr11:125298980-125299850 chr11:125383180-125385600 chr11:125322310-125324020 chr11:125433410-125434100 chr11:125451250-125452120 chr11:125516840-125517850 chr11:125311070-125312820 chr11:125669810-125672110 chr11:125899560-125900540 chr11:125169780-125171860 chr11:125280770-125281640 chr11:125316010-125318390 chr11:125351530-125351880 chr11:125135690-125136410 chr11:125876800-125878030 chr11:125991130-125991760 chr11:125993790-125995060 chr11:126019410-126020600 chr11:126023100-126025270 chr11:126153050-126155440 chr11:125992680-125993460 chr11:125300040-125301060 chr11:125543380-125545720 chr11:125673520-125675600 chr11:125472840-125473650 chr11:124922140-124924380 chr11:124950680-124951310 chr11:124951350-124951640 chr11:125324110-125325000 chr11:125823860-125824220 chr11:125837410-125839190 chr11:125244850-125246990 chr11:125820460-125822170 chr11:125085680-125087280 chr11:125204570-125205780 chr11:125212170-125213060 chr11:125214620-125216530 chr11:125327360-125328460 chr11:124980450-124980530 chr11:124980640-124981430 chr11:125061900-125064400 chr11:125097800-125099300 chr11:125199650-125201710 chr11:125242570-125244820 chr11:125260060-125261910 chr11:125312840-125315290 chr11:125347200-125349150 chr11:125379180-125379880 chr11:125403980-125405300 chr11:125288310-125288670 chr11:125385740-125388090 chr11:125304820-125306640 chr11:125422450-125424800 chr11:125228380-125229360

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Promoter:

chr11:125495560-125546150

False
 ChIP-seq based regulatory details of CHEK1
select * from encode where Experiment_target='CHEK1'
Sample ID Experiment target Biosample type Biosample term name GSM ID Tissue type Source
 Downstream target genes of CHEK1
 Protein-protein interaction of CHEK1
OFFICIAL_SYMBOL_A OFFICIAL_SYMBOL_B EXPERIMENTAL_SYSTEM PUBMED_ID ORGANISM_A_ID ORGANISM_B_ID SOURCE
CHEK1 CDC25A Reconstituted Complex 12963847 9606 9606 BIOGRID
CHEK1 CSNK2A1 Reconstituted Complex 15225637 9606 9606 BIOGRID
CHEK1 SFN Affinity Capture-Western 11896572 9606 9606 BIOGRID
CHEK1 CDKN1A Affinity Capture-Western 11896572 9606 9606 BIOGRID
CHEK1 TP53 Affinity Capture-Western 11896572 9606 9606 BIOGRID
CHEK1 BLM Affinity Capture-Western 15364958 9606 9606 BIOGRID
CHEK1 BLM Co-localization 15364958 9606 9606 BIOGRID
CHEK1 XIAP Reconstituted Complex 14759516 9606 9606 BIOGRID
CHEK1 PRKDC Reconstituted Complex 12756247 9606 9606 BIOGRID
CHEK1 CLSPN Reconstituted Complex 12766152 9606 9606 BIOGRID
CHEK1 CLSPN Affinity Capture-Western 12766152 9606 9606 BIOGRID
CHEK1 TP53 Biochemical Activity 12756247 9606 9606 BIOGRID
CHEK1 XRCC6 Affinity Capture-Western 12756247 9606 9606 BIOGRID
CHEK1 XRCC5 Affinity Capture-Western 12756247 9606 9606 BIOGRID
CHEK1 CDC25A Biochemical Activity 9278511 9606 9606 BIOGRID
CHEK1 CDC25B Biochemical Activity 9278511 9606 9606 BIOGRID
CHEK1 CDC25C Biochemical Activity 9278511 9606 9606 BIOGRID
CHEK1 CDC25A Biochemical Activity 12399544 9606 9606 BIOGRID
CHEK1 CDC25A Biochemical Activity 18480045 9606 9606 BIOGRID
CHEK1 MSH6 Affinity Capture-Western 20029092 9606 9606 BIOGRID
CHEK1 MDM4 Biochemical Activity 16511572 9606 9606 BIOGRID
CHEK1 POLA1 Affinity Capture-Western 19177015 9606 9606 BIOGRID
CHEK1 MDM4 Biochemical Activity 16163388 9606 9606 BIOGRID
CHEK1 CDC25C Biochemical Activity 17035231 9606 9606 BIOGRID
CHEK1 CLSPN Reconstituted Complex 16963448 9606 9606 BIOGRID
CHEK1 CLSPN Biochemical Activity 16963448 9606 9606 BIOGRID
CHEK1 MCPH1 Reconstituted Complex 16783362 9606 9606 BIOGRID
CHEK1 CDC25C Biochemical Activity 16705183 9606 9606 BIOGRID
CHEK1 XPO1 Reconstituted Complex 12676962 9606 9606 BIOGRID
CHEK1 CDC25C Biochemical Activity 15705874 9606 9606 BIOGRID
CHEK1 CDC25A Biochemical Activity 12759351 9606 9606 BIOGRID
CHEK1 DNMT1 Affinity Capture-Western 17991895 9606 9606 BIOGRID
CHEK1 DDB1 Affinity Capture-MS 19276361 9606 9606 BIOGRID
CHEK1 DDB1 Affinity Capture-Western 19276361 9606 9606 BIOGRID
CHEK1 CUL4A Affinity Capture-Western 19276361 9606 9606 BIOGRID
CHEK1 FANCE Biochemical Activity 17296736 9606 9606 BIOGRID
CHEK1 MEN1 Affinity Capture-Western 20969866 9606 9606 BIOGRID
CHEK1 TP53 Biochemical Activity 10673501 9606 9606 BIOGRID
CHEK1 LATS2 Biochemical Activity 21118956 9606 9606 BIOGRID
CHEK1 MEPE Affinity Capture-Western 19808933 9606 9606 BIOGRID
CHEK1 CDC25C Biochemical Activity 11836499 9606 9606 BIOGRID
CHEK1 BRCA1 Affinity Capture-Western 11836499 9606 9606 BIOGRID
CHEK1 CDC25C Biochemical Activity 11016625 9606 9606 BIOGRID
CHEK1 FEM1B Affinity Capture-Western 19330022 9606 9606 BIOGRID
CHEK1 CDC25C Biochemical Activity 19330022 9606 9606 BIOGRID
CHEK1 RB1 Biochemical Activity 17380128 9606 9606 BIOGRID
CHEK1 BRCA1 Biochemical Activity 17380128 9606 9606 BIOGRID
CHEK1 RB1 Reconstituted Complex 17380128 9606 9606 BIOGRID
CHEK1 TLK1 Biochemical Activity 12955071 9606 9606 BIOGRID
CHEK1 CDC25C Biochemical Activity 11390642 9606 9606 BIOGRID
CHEK1 NEK2 Co-fractionation 15311285 9606 9606 BIOGRID
CHEK1 CDC25C Biochemical Activity 12660173 9606 9606 BIOGRID
CHEK1 APP Reconstituted Complex 21832049 9606 9606 BIOGRID
CHEK1 MED15 Co-fractionation 22939629 9606 9606 BIOGRID
CHEK1 RELA Biochemical Activity 15775976 9606 9606 BIOGRID
CHEK1 CDC25C Biochemical Activity 10681541 9606 9606 BIOGRID
CHEK1 CDC25A Biochemical Activity 12676583 9606 9606 BIOGRID
CHEK1 CUL4A Affinity Capture-Western 23109433 9606 9606 BIOGRID
CHEK1 CUL1 Affinity Capture-Western 23109433 9606 9606 BIOGRID
CHEK1 DTL Affinity Capture-Western 23109433 9606 9606 BIOGRID
CHEK1 DDB1 Affinity Capture-Western 23109433 9606 9606 BIOGRID
CHEK1 CLSPN Affinity Capture-Western 23109433 9606 9606 BIOGRID
CHEK1 CUL1 Affinity Capture-Western 16137618 9606 9606 BIOGRID
CHEK1 CUL4A Affinity Capture-Western 16137618 9606 9606 BIOGRID
CHEK1 CDC25C Biochemical Activity 16330544 9606 9606 BIOGRID
CHEK1 HSP90AA1 Reconstituted Complex 16330544 9606 9606 BIOGRID
CHEK1 RAD51 Affinity Capture-Western 15665856 9606 9606 BIOGRID
CHEK1 BTG3 Affinity Capture-Western 23533280 9606 9606 BIOGRID
CHEK1 CLSPN Affinity Capture-Western 16123041 9606 9606 BIOGRID
CHEK1 PIGM Two-hybrid 21988832 9606 9606 BIOGRID
CHEK1 DDB1 Affinity Capture-Western 25024738 9606 9606 BIOGRID
CHEK1 SETMAR Affinity Capture-Western 25024738 9606 9606 BIOGRID
CHEK1 LATS2 Biochemical Activity 23886938 9606 9606 BIOGRID
CHEK1 FUS Affinity Capture-MS 25852190 9606 9606 BIOGRID
CHEK1 RAD23A Affinity Capture-Western 26296656 9606 9606 BIOGRID
CHEK1 USP7 Affinity Capture-Western 26296656 9606 9606 BIOGRID
CHEK1 FANCD2 Biochemical Activity 19861535 9606 9606 BIOGRID
CHEK1 UBE2T Biochemical Activity 28162934 9606 9606 BIOGRID
CHEK1 IGF1R Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 VEGFA Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 PTEN Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 MTOR Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 SMO Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 PARP1 Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 PRKDC Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 TYMS Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 PIK3CA Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 SMARCA4 Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 VHL Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 MAP2K1 Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 SRC Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 MET Negative Genetic 28319113 9606 9606 BIOGRID
CHEK1 KCTD3 Affinity Capture-MS 27173435 9606 9606 BIOGRID
CHEK1 KIF13B Affinity Capture-MS 27173435 9606 9606 BIOGRID
CHEK1 ZBTB21 Affinity Capture-MS 27173435 9606 9606 BIOGRID
CHEK1 GIGYF1 Affinity Capture-MS 27173435 9606 9606 BIOGRID
CHEK1 LRFN1 Affinity Capture-MS 27173435 9606 9606 BIOGRID
CHEK1 DENND1A Affinity Capture-MS 27173435 9606 9606 BIOGRID
CHEK1 SRGAP2 Affinity Capture-MS 27173435 9606 9606 BIOGRID
CHEK1 CBY1 Affinity Capture-MS 27173435 9606 9606 BIOGRID
CHEK1 WEE1 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 CDC6 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 CDC73 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 BLM Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 RFC1 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 RAD17 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 FZR1 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 ATAD5 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 LLGL1 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 CDC14A Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 RPS10 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 WRN Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 ATR Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 DAAM1 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 TTN Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 BRD4 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 MTOR Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 SMARCC1 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 TUSC3 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 TCEA1 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 FHIT Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 USP11 Synthetic Lethality 27453043 9606 9606 BIOGRID
CHEK1 BCL2L1 Biochemical Activity 22617334 9606 9606 BIOGRID
CHEK1 FBXO6 Affinity Capture-Western 28180282 9606 9606 BIOGRID
CHEK1 ATXN3 Affinity Capture-Western 28180282 9606 9606 BIOGRID
CHEK1 DDB1 Affinity Capture-Western 28192407 9606 9606 BIOGRID
CHEK1 CNTN2 Affinity Capture-Western 15107832 9606 9606 BIOGRID
CHEK1 CDC25C Biochemical Activity 29735693 9606 9606 BIOGRID
CHEK1 USP3 Reconstituted Complex 29735693 9606 9606 BIOGRID
CHEK1 USP3 Affinity Capture-Western 29735693 9606 9606 BIOGRID
CHEK1 BTG3 Affinity Capture-Western 29735693 9606 9606 BIOGRID
CHEK1 MCM2 Affinity Capture-Western 25049228 9606 9606 BIOGRID
CHEK1 MCM3 Affinity Capture-Western 25049228 9606 9606 BIOGRID
CHEK1 MCM4 Affinity Capture-Western 25049228 9606 9606 BIOGRID
CHEK1 MCM5 Affinity Capture-Western 25049228 9606 9606 BIOGRID
CHEK1 MCM6 Affinity Capture-Western 25049228 9606 9606 BIOGRID
CHEK1 MCM7 Affinity Capture-Western 25049228 9606 9606 BIOGRID
CHEK1 MCM2 Reconstituted Complex 25049228 9606 9606 BIOGRID
CHEK1 MCM6 Reconstituted Complex 25049228 9606 9606 BIOGRID
CHEK1 MCM7 Reconstituted Complex 25049228 9606 9606 BIOGRID
CHEK1 GINS1 Affinity Capture-Western 25049228 9606 9606 BIOGRID
CHEK1 TP53BP1 Biochemical Activity 17984114 9606 9606 BIOGRID
CHEK1 BRCA2 Biochemical Activity 18317453 9606 9606 BIOGRID
CHEK1 BTRC Affinity Capture-Western 30428154 9606 9606 BIOGRID
CHEK1 MAPT Biochemical Activity 20159774 9606 9606 BIOGRID
CHEK1 USP7 Affinity Capture-Western 32447346 9606 9606 BIOGRID
CHEK1 USP7 Co-localization 32447346 9606 9606 BIOGRID
CHEK1 FZR1 Biochemical Activity 32345958 9606 9606 BIOGRID
CHEK1 TRAF4 Affinity Capture-MS 32357935 9606 9606 BIOGRID
CHEK1 TRAF4 Affinity Capture-Western 32357935 9606 9606 BIOGRID
CHEK1 TRAF4 Reconstituted Complex 32357935 9606 9606 BIOGRID
CHEK1 CDC25C Biochemical Activity 32357935 9606 9606 BIOGRID
CHEK1 MCD1 Biochemical Activity 18614046 9606 559292 BIOGRID
 Annotation of CHEK1
 TCGA cancer survival map of CHEK1


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.
Reset Add The plot axis-x order will follow the list.


Calculate the hazards ratio based on Cox PH Model.
We use log2(TPM + 1) for log-scale.
All Add
Reset The plot is based on the datasets of list.


 Disease information of  CHEK1