TcoF overview
| TcoF: | CHEK1 | |
| GeneID: | 9318 | |
| Name: | Serine/threonine-protein kinase Chk1 | |
| Ensembl: | ENSG00000149554 | |
| Species: | Human | |
| Class: | class 2 | |
| Family: | Others | |
| Disease: | 8 | |
| Go term: | 38 | |
| Pathway: | 25 | |
| Hallmark: | 4 | |
| Super Enhancer: |
chr11:125494569-125497218 |
|
| Enhancer: |
chr11:125105010-125106880 chr11:125132580-125134280 chr11:125462810-125463530 chr11:125496540-125496640 chr11:125365510-125366010 chr11:125496730-125497500 chr11:125514160-125514400 chr11:125514540-125515400 chr11:125184100-125186200 chr11:125240040-125242190 chr11:125333470-125335770 chr11:125321090-125322220 chr11:125463620-125465770 chr11:125298980-125299850 chr11:125383180-125385600 chr11:125322310-125324020 chr11:125433410-125434100 chr11:125451250-125452120 chr11:125516840-125517850 chr11:125311070-125312820 chr11:125669810-125672110 chr11:125899560-125900540 chr11:125169780-125171860 chr11:125280770-125281640 chr11:125316010-125318390 chr11:125351530-125351880 chr11:125135690-125136410 chr11:125876800-125878030 chr11:125991130-125991760 chr11:125993790-125995060 chr11:126019410-126020600 chr11:126023100-126025270 chr11:126153050-126155440 chr11:125992680-125993460 chr11:125300040-125301060 chr11:125543380-125545720 chr11:125673520-125675600 chr11:125472840-125473650 chr11:124922140-124924380 chr11:124950680-124951310 chr11:124951350-124951640 chr11:125324110-125325000 chr11:125823860-125824220 chr11:125837410-125839190 chr11:125244850-125246990 chr11:125820460-125822170 chr11:125085680-125087280 chr11:125204570-125205780 chr11:125212170-125213060 chr11:125214620-125216530 chr11:125327360-125328460 chr11:124980450-124980530 chr11:124980640-124981430 chr11:125061900-125064400 chr11:125097800-125099300 chr11:125199650-125201710 chr11:125242570-125244820 chr11:125260060-125261910 chr11:125312840-125315290 chr11:125347200-125349150 chr11:125379180-125379880 chr11:125403980-125405300 chr11:125288310-125288670 chr11:125385740-125388090 chr11:125304820-125306640 chr11:125422450-125424800 chr11:125228380-125229360 |
|
| Promoter: |
chr11:125495560-125546150 |
ChIP-seq based regulatory details of CHEK1
| Sample ID | Experiment target | Biosample type | Biosample term name | GSM ID | Tissue type | Source |
|---|
Downstream target genes of CHEK1
Upstream regulatory details of CHEK1
Protein-protein interaction of CHEK1
| OFFICIAL_SYMBOL_A | OFFICIAL_SYMBOL_B | EXPERIMENTAL_SYSTEM | PUBMED_ID | ORGANISM_A_ID | ORGANISM_B_ID | SOURCE |
|---|---|---|---|---|---|---|
| CHEK1 | CDC25A | Reconstituted Complex | 12963847 | 9606 | 9606 | BIOGRID |
| CHEK1 | CSNK2A1 | Reconstituted Complex | 15225637 | 9606 | 9606 | BIOGRID |
| CHEK1 | SFN | Affinity Capture-Western | 11896572 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDKN1A | Affinity Capture-Western | 11896572 | 9606 | 9606 | BIOGRID |
| CHEK1 | TP53 | Affinity Capture-Western | 11896572 | 9606 | 9606 | BIOGRID |
| CHEK1 | BLM | Affinity Capture-Western | 15364958 | 9606 | 9606 | BIOGRID |
| CHEK1 | BLM | Co-localization | 15364958 | 9606 | 9606 | BIOGRID |
| CHEK1 | XIAP | Reconstituted Complex | 14759516 | 9606 | 9606 | BIOGRID |
| CHEK1 | PRKDC | Reconstituted Complex | 12756247 | 9606 | 9606 | BIOGRID |
| CHEK1 | CLSPN | Reconstituted Complex | 12766152 | 9606 | 9606 | BIOGRID |
| CHEK1 | CLSPN | Affinity Capture-Western | 12766152 | 9606 | 9606 | BIOGRID |
| CHEK1 | TP53 | Biochemical Activity | 12756247 | 9606 | 9606 | BIOGRID |
| CHEK1 | XRCC6 | Affinity Capture-Western | 12756247 | 9606 | 9606 | BIOGRID |
| CHEK1 | XRCC5 | Affinity Capture-Western | 12756247 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25A | Biochemical Activity | 9278511 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25B | Biochemical Activity | 9278511 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25C | Biochemical Activity | 9278511 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25A | Biochemical Activity | 12399544 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25A | Biochemical Activity | 18480045 | 9606 | 9606 | BIOGRID |
| CHEK1 | MSH6 | Affinity Capture-Western | 20029092 | 9606 | 9606 | BIOGRID |
| CHEK1 | MDM4 | Biochemical Activity | 16511572 | 9606 | 9606 | BIOGRID |
| CHEK1 | POLA1 | Affinity Capture-Western | 19177015 | 9606 | 9606 | BIOGRID |
| CHEK1 | MDM4 | Biochemical Activity | 16163388 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25C | Biochemical Activity | 17035231 | 9606 | 9606 | BIOGRID |
| CHEK1 | CLSPN | Reconstituted Complex | 16963448 | 9606 | 9606 | BIOGRID |
| CHEK1 | CLSPN | Biochemical Activity | 16963448 | 9606 | 9606 | BIOGRID |
| CHEK1 | MCPH1 | Reconstituted Complex | 16783362 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25C | Biochemical Activity | 16705183 | 9606 | 9606 | BIOGRID |
| CHEK1 | XPO1 | Reconstituted Complex | 12676962 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25C | Biochemical Activity | 15705874 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25A | Biochemical Activity | 12759351 | 9606 | 9606 | BIOGRID |
| CHEK1 | DNMT1 | Affinity Capture-Western | 17991895 | 9606 | 9606 | BIOGRID |
| CHEK1 | DDB1 | Affinity Capture-MS | 19276361 | 9606 | 9606 | BIOGRID |
| CHEK1 | DDB1 | Affinity Capture-Western | 19276361 | 9606 | 9606 | BIOGRID |
| CHEK1 | CUL4A | Affinity Capture-Western | 19276361 | 9606 | 9606 | BIOGRID |
| CHEK1 | FANCE | Biochemical Activity | 17296736 | 9606 | 9606 | BIOGRID |
| CHEK1 | MEN1 | Affinity Capture-Western | 20969866 | 9606 | 9606 | BIOGRID |
| CHEK1 | TP53 | Biochemical Activity | 10673501 | 9606 | 9606 | BIOGRID |
| CHEK1 | LATS2 | Biochemical Activity | 21118956 | 9606 | 9606 | BIOGRID |
| CHEK1 | MEPE | Affinity Capture-Western | 19808933 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25C | Biochemical Activity | 11836499 | 9606 | 9606 | BIOGRID |
| CHEK1 | BRCA1 | Affinity Capture-Western | 11836499 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25C | Biochemical Activity | 11016625 | 9606 | 9606 | BIOGRID |
| CHEK1 | FEM1B | Affinity Capture-Western | 19330022 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25C | Biochemical Activity | 19330022 | 9606 | 9606 | BIOGRID |
| CHEK1 | RB1 | Biochemical Activity | 17380128 | 9606 | 9606 | BIOGRID |
| CHEK1 | BRCA1 | Biochemical Activity | 17380128 | 9606 | 9606 | BIOGRID |
| CHEK1 | RB1 | Reconstituted Complex | 17380128 | 9606 | 9606 | BIOGRID |
| CHEK1 | TLK1 | Biochemical Activity | 12955071 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25C | Biochemical Activity | 11390642 | 9606 | 9606 | BIOGRID |
| CHEK1 | NEK2 | Co-fractionation | 15311285 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25C | Biochemical Activity | 12660173 | 9606 | 9606 | BIOGRID |
| CHEK1 | APP | Reconstituted Complex | 21832049 | 9606 | 9606 | BIOGRID |
| CHEK1 | MED15 | Co-fractionation | 22939629 | 9606 | 9606 | BIOGRID |
| CHEK1 | RELA | Biochemical Activity | 15775976 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25C | Biochemical Activity | 10681541 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25A | Biochemical Activity | 12676583 | 9606 | 9606 | BIOGRID |
| CHEK1 | CUL4A | Affinity Capture-Western | 23109433 | 9606 | 9606 | BIOGRID |
| CHEK1 | CUL1 | Affinity Capture-Western | 23109433 | 9606 | 9606 | BIOGRID |
| CHEK1 | DTL | Affinity Capture-Western | 23109433 | 9606 | 9606 | BIOGRID |
| CHEK1 | DDB1 | Affinity Capture-Western | 23109433 | 9606 | 9606 | BIOGRID |
| CHEK1 | CLSPN | Affinity Capture-Western | 23109433 | 9606 | 9606 | BIOGRID |
| CHEK1 | CUL1 | Affinity Capture-Western | 16137618 | 9606 | 9606 | BIOGRID |
| CHEK1 | CUL4A | Affinity Capture-Western | 16137618 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25C | Biochemical Activity | 16330544 | 9606 | 9606 | BIOGRID |
| CHEK1 | HSP90AA1 | Reconstituted Complex | 16330544 | 9606 | 9606 | BIOGRID |
| CHEK1 | RAD51 | Affinity Capture-Western | 15665856 | 9606 | 9606 | BIOGRID |
| CHEK1 | BTG3 | Affinity Capture-Western | 23533280 | 9606 | 9606 | BIOGRID |
| CHEK1 | CLSPN | Affinity Capture-Western | 16123041 | 9606 | 9606 | BIOGRID |
| CHEK1 | PIGM | Two-hybrid | 21988832 | 9606 | 9606 | BIOGRID |
| CHEK1 | DDB1 | Affinity Capture-Western | 25024738 | 9606 | 9606 | BIOGRID |
| CHEK1 | SETMAR | Affinity Capture-Western | 25024738 | 9606 | 9606 | BIOGRID |
| CHEK1 | LATS2 | Biochemical Activity | 23886938 | 9606 | 9606 | BIOGRID |
| CHEK1 | FUS | Affinity Capture-MS | 25852190 | 9606 | 9606 | BIOGRID |
| CHEK1 | RAD23A | Affinity Capture-Western | 26296656 | 9606 | 9606 | BIOGRID |
| CHEK1 | USP7 | Affinity Capture-Western | 26296656 | 9606 | 9606 | BIOGRID |
| CHEK1 | FANCD2 | Biochemical Activity | 19861535 | 9606 | 9606 | BIOGRID |
| CHEK1 | UBE2T | Biochemical Activity | 28162934 | 9606 | 9606 | BIOGRID |
| CHEK1 | IGF1R | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | VEGFA | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | PTEN | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | MTOR | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | SMO | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | PARP1 | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | PRKDC | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | TYMS | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | PIK3CA | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | SMARCA4 | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | VHL | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | MAP2K1 | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | SRC | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | MET | Negative Genetic | 28319113 | 9606 | 9606 | BIOGRID |
| CHEK1 | KCTD3 | Affinity Capture-MS | 27173435 | 9606 | 9606 | BIOGRID |
| CHEK1 | KIF13B | Affinity Capture-MS | 27173435 | 9606 | 9606 | BIOGRID |
| CHEK1 | ZBTB21 | Affinity Capture-MS | 27173435 | 9606 | 9606 | BIOGRID |
| CHEK1 | GIGYF1 | Affinity Capture-MS | 27173435 | 9606 | 9606 | BIOGRID |
| CHEK1 | LRFN1 | Affinity Capture-MS | 27173435 | 9606 | 9606 | BIOGRID |
| CHEK1 | DENND1A | Affinity Capture-MS | 27173435 | 9606 | 9606 | BIOGRID |
| CHEK1 | SRGAP2 | Affinity Capture-MS | 27173435 | 9606 | 9606 | BIOGRID |
| CHEK1 | CBY1 | Affinity Capture-MS | 27173435 | 9606 | 9606 | BIOGRID |
| CHEK1 | WEE1 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC6 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC73 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | BLM | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | RFC1 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | RAD17 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | FZR1 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | ATAD5 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | LLGL1 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC14A | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | RPS10 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | WRN | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | ATR | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | DAAM1 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | TTN | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | BRD4 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | MTOR | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | SMARCC1 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | TUSC3 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | TCEA1 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | FHIT | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | USP11 | Synthetic Lethality | 27453043 | 9606 | 9606 | BIOGRID |
| CHEK1 | BCL2L1 | Biochemical Activity | 22617334 | 9606 | 9606 | BIOGRID |
| CHEK1 | FBXO6 | Affinity Capture-Western | 28180282 | 9606 | 9606 | BIOGRID |
| CHEK1 | ATXN3 | Affinity Capture-Western | 28180282 | 9606 | 9606 | BIOGRID |
| CHEK1 | DDB1 | Affinity Capture-Western | 28192407 | 9606 | 9606 | BIOGRID |
| CHEK1 | CNTN2 | Affinity Capture-Western | 15107832 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25C | Biochemical Activity | 29735693 | 9606 | 9606 | BIOGRID |
| CHEK1 | USP3 | Reconstituted Complex | 29735693 | 9606 | 9606 | BIOGRID |
| CHEK1 | USP3 | Affinity Capture-Western | 29735693 | 9606 | 9606 | BIOGRID |
| CHEK1 | BTG3 | Affinity Capture-Western | 29735693 | 9606 | 9606 | BIOGRID |
| CHEK1 | MCM2 | Affinity Capture-Western | 25049228 | 9606 | 9606 | BIOGRID |
| CHEK1 | MCM3 | Affinity Capture-Western | 25049228 | 9606 | 9606 | BIOGRID |
| CHEK1 | MCM4 | Affinity Capture-Western | 25049228 | 9606 | 9606 | BIOGRID |
| CHEK1 | MCM5 | Affinity Capture-Western | 25049228 | 9606 | 9606 | BIOGRID |
| CHEK1 | MCM6 | Affinity Capture-Western | 25049228 | 9606 | 9606 | BIOGRID |
| CHEK1 | MCM7 | Affinity Capture-Western | 25049228 | 9606 | 9606 | BIOGRID |
| CHEK1 | MCM2 | Reconstituted Complex | 25049228 | 9606 | 9606 | BIOGRID |
| CHEK1 | MCM6 | Reconstituted Complex | 25049228 | 9606 | 9606 | BIOGRID |
| CHEK1 | MCM7 | Reconstituted Complex | 25049228 | 9606 | 9606 | BIOGRID |
| CHEK1 | GINS1 | Affinity Capture-Western | 25049228 | 9606 | 9606 | BIOGRID |
| CHEK1 | TP53BP1 | Biochemical Activity | 17984114 | 9606 | 9606 | BIOGRID |
| CHEK1 | BRCA2 | Biochemical Activity | 18317453 | 9606 | 9606 | BIOGRID |
| CHEK1 | BTRC | Affinity Capture-Western | 30428154 | 9606 | 9606 | BIOGRID |
| CHEK1 | MAPT | Biochemical Activity | 20159774 | 9606 | 9606 | BIOGRID |
| CHEK1 | USP7 | Affinity Capture-Western | 32447346 | 9606 | 9606 | BIOGRID |
| CHEK1 | USP7 | Co-localization | 32447346 | 9606 | 9606 | BIOGRID |
| CHEK1 | FZR1 | Biochemical Activity | 32345958 | 9606 | 9606 | BIOGRID |
| CHEK1 | TRAF4 | Affinity Capture-MS | 32357935 | 9606 | 9606 | BIOGRID |
| CHEK1 | TRAF4 | Affinity Capture-Western | 32357935 | 9606 | 9606 | BIOGRID |
| CHEK1 | TRAF4 | Reconstituted Complex | 32357935 | 9606 | 9606 | BIOGRID |
| CHEK1 | CDC25C | Biochemical Activity | 32357935 | 9606 | 9606 | BIOGRID |
| CHEK1 | MCD1 | Biochemical Activity | 18614046 | 9606 | 559292 | BIOGRID |
Annotation of CHEK1
TCGA cancer survival map of CHEK1
Expression of CHEK1
Disease information of CHEK1