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TcoF overview
TcoF: MDM4
GeneID: 10025
Name: MDM4 protein variant G
Ensembl: ENSG00000198625
Species: Human
Class: class HC
Family: Others
Disease: 19
Go term: 21
Pathway: 11
Hallmark: 3
Super Enhancer:

chr1:204449616-204491656 chr1:204433816-204477483 chr1:204450504-204477740 chr1:204434792-204495623 chr1:204448882-204500898 chr1:204534045-204544745 chr1:204447066-204495690 chr1:204449160-204495490 chr1:204450553-204477470 chr1:204449164-204496341 chr1:204449748-204496603 chr1:204449569-204492048 chr1:204447733-204501251 chr1:204440967-204477483 chr1:204447477-204487808 chr1:204448231-204496397 chr1:204434196-204490618 chr1:204435985-204477761 chr1:204534957-204555304 chr1:204447814-204477816 chr1:204447806-204491150 chr1:204447606-204477593 chr1:204449073-204492326 chr1:204441829-204492564 chr1:204461554-204492183 chr1:204460443-204491504 chr1:204461330-204491396 chr1:204461241-204492003 chr1:204481375-204492181 chr1:204474977-204488675 chr1:204463183-204491402 chr1:204460504-204491567 chr1:204462592-204491262 chr1:204462567-204515060 chr1:204462314-204496254 chr1:204462308-204498990 chr1:204462328-204496310 chr1:204475491-204493739 chr1:204461109-204491424 chr1:204476231-204491322 chr1:204462707-204491356 chr1:204462196-204491409 chr1:204461088-204495400 chr1:204460732-204495682 chr1:204461449-204494803 chr1:204461287-204491113 chr1:204462605-204549171 chr1:204462271-204549348 chr1:204462607-204488598 chr1:204462659-204489397 chr1:204462410-204488195 chr1:204462500-204490708 chr1:204462658-204492614 chr1:204462660-204494834
Enhancer:

chr1:204170940-204172020 chr1:204213170-204213990 chr1:204214130-204214740 chr1:204394870-204396770 chr1:204397350-204399040 chr1:204410690-204411650 chr1:204411760-204412540 chr1:204416710-204418310 chr1:204425180-204426160 chr1:204426190-204426850 chr1:204494720-204495480 chr1:204505410-204506550 chr1:204506630-204507330 chr1:204513810-204515920 chr1:204516010-204518240 chr1:204652400-204654440 chr1:204415270-204416560 chr1:204499950-204501310 chr1:204507440-204509550 chr1:204512070-204513660 chr1:204101380-204103640 chr1:204103820-204105500 chr1:204503130-204503950 chr1:204975700-204978150 chr1:204126490-204128520 chr1:204128720-204129680 chr1:204409450-204410590 chr1:204326220-204327970 chr1:204672860-204674000 chr1:204892310-204894140 chr1:204797910-204800080 chr1:204047110-204048330 chr1:204119220-204120720 chr1:204157280-204159460 chr1:204316800-204318460 chr1:204605940-204607680 chr1:204615660-204617550 chr1:204643450-204643650 chr1:204677610-204678570 chr1:204691360-204693040 chr1:204827300-204829690 chr1:204857900-204859810 chr1:204915300-204916730 chr1:204957940-204960410 chr1:204960430-204962630 chr1:205088920-205090980 chr1:204536910-204538990 chr1:204408200-204409310 chr1:204412730-204413190 chr1:204413290-204413450 chr1:204085810-204086240 chr1:204218390-204219670 chr1:204227000-204228380 chr1:204399170-204400790 chr1:204402550-204402920 chr1:204413550-204415080 chr1:204234170-204236600 chr1:204429790-204432010 chr1:204432030-204433130 chr1:204547040-204549330 chr1:204433730-204434340 chr1:204434450-204436840 chr1:204489600-204491870 chr1:204492320-204494610 chr1:204082260-204083020 chr1:204083730-204085630 chr1:204092340-204092780 chr1:204093990-204094980 chr1:204130540-204131140 chr1:203830840-203832790 chr1:203981720-203982960 chr1:203984270-203986190 chr1:203987420-203988640 chr1:204336440-204337020 chr1:205031130-205031560 chr1:203840280-203842450 chr1:203894240-203896700 chr1:203902880-203904180 chr1:203905850-203908310 chr1:203925840-203927320 chr1:203937680-203939480 chr1:204009520-204010210 chr1:204033880-204035780 chr1:204111390-204111770 chr1:204198230-204199540 chr1:204206890-204207590 chr1:204400920-204401320 chr1:204418420-204418970 chr1:203898540-203899950 chr1:204026160-204027440 chr1:204056960-204059110 chr1:204260830-204262500 chr1:204290790-204291130 chr1:204353840-204354460 chr1:204376250-204378610 chr1:204560170-204562260 chr1:204940280-204942400 chr1:204244330-204244700 chr1:204244780-204245150 chr1:204246030-204246380 chr1:204246460-204247770 chr1:204403740-204405790 chr1:204811740-204812450 chr1:204854300-204855430 chr1:204070920-204071900 chr1:204181990-204183000 chr1:204406740-204408060 chr1:204052290-204054380 chr1:204179800-204181810 chr1:204258100-204258920 chr1:204272640-204273790 chr1:204282710-204283930 chr1:204295310-204297080 chr1:204300270-204302630 chr1:204302690-204302920 chr1:204303510-204305730 chr1:204352260-204353000 chr1:204887910-204888460 chr1:204335040-204335690 chr1:204511030-204511660 chr1:204269830-204271400 chr1:204423920-204424980 chr1:204428440-204429000 chr1:203575130-203577530 chr1:203599620-203601290 chr1:203601980-203602620 chr1:203793470-203794060 chr1:203857090-203859340 chr1:203875350-203877150 chr1:204083150-204083440 chr1:204114110-204114870 chr1:204219740-204222080 chr1:204599220-204600250 chr1:204694670-204696000 chr1:204751150-204752780 chr1:205275440-205277290 chr1:203618030-203620470 chr1:204552950-204554850 chr1:203486420-203486930 chr1:203494850-203496660 chr1:203557900-203558820 chr1:203566150-203568170 chr1:204076300-204077230 chr1:204077400-204078510 chr1:204079540-204081200 chr1:204081900-204082040 chr1:204437400-204437990 chr1:204439020-204439280 chr1:204585210-204585510 chr1:204620750-204622520 chr1:204699960-204700680 chr1:204894560-204895310 chr1:204896180-204898520 chr1:204489200-204489410

Promoter:

chr1:204485507-204527248

 ChIP-seq based regulatory details of MDM4
Sample ID Experiment target Biosample type Biosample term name GSM ID Tissue type Source
 Downstream target genes of MDM4
 Upstream regulatory details of MDM4
 Protein-protein interaction of MDM4
OFFICIAL_SYMBOL_A OFFICIAL_SYMBOL_B EXPERIMENTAL_SYSTEM PUBMED_ID ORGANISM_A_ID ORGANISM_B_ID SOURCE
MDM4 SMAD3 Reconstituted Complex 12483531 9606 9606 BIOGRID
MDM4 SMAD4 Reconstituted Complex 12483531 9606 9606 BIOGRID
MDM4 EP300 Reconstituted Complex 12483531 9606 9606 BIOGRID
MDM4 MDM2 Reconstituted Complex 12483531 9606 9606 BIOGRID
MDM4 MDM2 Biochemical Activity 12393902 9606 9606 BIOGRID
MDM4 TP53 Biochemical Activity 12393902 9606 9606 BIOGRID
MDM4 UBE2D1 Reconstituted Complex 12393902 9606 9606 BIOGRID
MDM4 CDKN2A Affinity Capture-Western 11297540 9606 9606 BIOGRID
MDM4 TP53 Reconstituted Complex 9226370 9606 9606 BIOGRID
MDM4 TP53 Reconstituted Complex 18485870 9606 9606 BIOGRID
MDM4 YWHAG Affinity Capture-Western 16511572 9606 9606 BIOGRID
MDM4 YWHAE Affinity Capture-Western 16227609 9606 9606 BIOGRID
MDM4 YWHAB Affinity Capture-Western 16227609 9606 9606 BIOGRID
MDM4 CSNK1A1 Affinity Capture-Western 16024788 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 16024788 9606 9606 BIOGRID
MDM4 MDM2 Reconstituted Complex 20473904 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 11223036 9606 9606 BIOGRID
MDM4 TP73 Affinity Capture-Western 11223036 9606 9606 BIOGRID
MDM4 USP7 Reconstituted Complex 20713061 9606 9606 BIOGRID
MDM4 USP7 Protein-peptide 20713061 9606 9606 BIOGRID
MDM4 MDM4 Biochemical Activity 17301054 9606 9606 BIOGRID
MDM4 CDKN1A Affinity Capture-Western 18086887 9606 9606 BIOGRID
MDM4 CDKN1A Reconstituted Complex 18086887 9606 9606 BIOGRID
MDM4 PSMC5 Co-fractionation 18086887 9606 9606 BIOGRID
MDM4 PSMD2 Affinity Capture-Western 18086887 9606 9606 BIOGRID
MDM4 TP63 Reconstituted Complex 21088494 9606 9606 BIOGRID
MDM4 TP53 Reconstituted Complex 21088494 9606 9606 BIOGRID
MDM4 TP73 Reconstituted Complex 21088494 9606 9606 BIOGRID
MDM4 TP53 Biochemical Activity 17301054 9606 9606 BIOGRID
MDM4 MDM2 Biochemical Activity 19683495 9606 9606 BIOGRID
MDM4 USP2 Affinity Capture-Western 19838211 9606 9606 BIOGRID
MDM4 USP2 Reconstituted Complex 19838211 9606 9606 BIOGRID
MDM4 MDM2 Reconstituted Complex 19838211 9606 9606 BIOGRID
MDM4 RFWD2 Affinity Capture-Western 20333547 9606 9606 BIOGRID
MDM4 RCHY1 Affinity Capture-Western 20333547 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 20484049 9606 9606 BIOGRID
MDM4 CDKN1A Affinity Capture-Western 21148311 9606 9606 BIOGRID
MDM4 YWHAG Affinity Capture-Western 21148311 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 21925390 9606 9606 BIOGRID
MDM4 CSNK1A1 Affinity Capture-Western 21925390 9606 9606 BIOGRID
MDM4 RN5S1@ Affinity Capture-Western 21925390 9606 9606 BIOGRID
MDM4 YWHAB Affinity Capture-Western 21925390 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 21925390 9606 9606 BIOGRID
MDM4 RN5S1@ Affinity Capture-RNA 21925390 9606 9606 BIOGRID
MDM4 TP53 Biochemical Activity 21965653 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 12874296 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 12874296 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 22266850 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 22266850 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 17159902 9606 9606 BIOGRID
MDM4 TP53 PCA 22266850 9606 9606 BIOGRID
MDM4 MDM2 PCA 22266850 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 10827196 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 21075307 9606 9606 BIOGRID
MDM4 TP53 PCA 21075307 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 16055726 9606 9606 BIOGRID
MDM4 UBE2D2 Reconstituted Complex 20705607 9606 9606 BIOGRID
MDM4 ABL1 Affinity Capture-Western 19075013 9606 9606 BIOGRID
MDM4 TP53 Protein-peptide 19305137 9606 9606 BIOGRID
MDM4 TP53 Co-crystal Structure 18677113 9606 9606 BIOGRID
MDM4 TP53 Reconstituted Complex 17875722 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 10608892 9606 9606 BIOGRID
MDM4 MDM2 Reconstituted Complex 10608892 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 10608892 9606 9606 BIOGRID
MDM4 YWHAQ Affinity Capture-MS 18356162 9606 9606 BIOGRID
MDM4 YWHAQ Affinity Capture-Western 18356162 9606 9606 BIOGRID
MDM4 YWHAE Affinity Capture-Western 18356162 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 22374672 9606 9606 BIOGRID
MDM4 UBE2D1 Reconstituted Complex 17301054 9606 9606 BIOGRID
MDM4 UBE2D3 Reconstituted Complex 19683495 9606 9606 BIOGRID
MDM4 RB1 Affinity Capture-Western 16510145 9606 9606 BIOGRID
MDM4 APP Reconstituted Complex 21832049 9606 9606 BIOGRID
MDM4 PPP1CA Affinity Capture-Western 23277204 9606 9606 BIOGRID
MDM4 YWHAQ Affinity Capture-MS 17110929 9606 9606 BIOGRID
MDM4 CSNK1A1 Affinity Capture-MS 17110929 9606 9606 BIOGRID
MDM4 BCL2 Affinity Capture-Western 19521340 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 19521340 9606 9606 BIOGRID
MDM4 CSNK1A1 Affinity Capture-Western 23028042 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 23028042 9606 9606 BIOGRID
MDM4 TP53 Reconstituted Complex 23028042 9606 9606 BIOGRID
MDM4 TP53 Biochemical Activity 23671280 9606 9606 BIOGRID
MDM4 MDM4 Co-purification 24127580 9606 9606 BIOGRID
MDM4 MDM4 Reconstituted Complex 24127580 9606 9606 BIOGRID
MDM4 TP53 Reconstituted Complex 24127580 9606 9606 BIOGRID
MDM4 TP53 Biochemical Activity 24127580 9606 9606 BIOGRID
MDM4 UBE2D2 Biochemical Activity 24127580 9606 9606 BIOGRID
MDM4 USP2 Affinity Capture-Western 24445145 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 24445145 9606 9606 BIOGRID
MDM4 BCL2 Affinity Capture-Western 24445145 9606 9606 BIOGRID
MDM4 TP53 Co-localization 24445145 9606 9606 BIOGRID
MDM4 USP2 Co-localization 24445145 9606 9606 BIOGRID
MDM4 MDM4 Biochemical Activity 24755078 9606 9606 BIOGRID
MDM4 UBC Biochemical Activity 24755078 9606 9606 BIOGRID
MDM4 MDM2 Co-crystal Structure 24755078 9606 9606 BIOGRID
MDM4 TP53 Reconstituted Complex 10075736 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 23946421 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 23946421 9606 9606 BIOGRID
MDM4 CD160 Two-hybrid 25416956 9606 9606 BIOGRID
MDM4 CAPN7 Two-hybrid 25416956 9606 9606 BIOGRID
MDM4 RNF115 Two-hybrid 25416956 9606 9606 BIOGRID
MDM4 RAD54B Affinity Capture-Western 25384516 9606 9606 BIOGRID
MDM4 SMARCA2 Reconstituted Complex 25384516 9606 9606 BIOGRID
MDM4 RAD54B Reconstituted Complex 25384516 9606 9606 BIOGRID
MDM4 MDM2 Reconstituted Complex 25384516 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 11606419 9606 9606 BIOGRID
MDM4 MDM4 Affinity Capture-Western 25888903 9606 9606 BIOGRID
MDM4 TP53 Reconstituted Complex 20515689 9606 9606 BIOGRID
MDM4 TP53 Co-crystal Structure 20515689 9606 9606 BIOGRID
MDM4 NBN Affinity Capture-Western 24608433 9606 9606 BIOGRID
MDM4 MRE11A Affinity Capture-Western 24608433 9606 9606 BIOGRID
MDM4 RAD50 Affinity Capture-Western 24608433 9606 9606 BIOGRID
MDM4 USP22 Affinity Capture-Western 25547493 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 25105592 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 25659040 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 25703327 9606 9606 BIOGRID
MDM4 RB1 Affinity Capture-Western 25703327 9606 9606 BIOGRID
MDM4 CSNK1A1 Affinity Capture-Western 25825738 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 25825738 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 26359458 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 27617579 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-MS 28514442 9606 9606 BIOGRID
MDM4 CSNK1A1 Affinity Capture-MS 28514442 9606 9606 BIOGRID
MDM4 FAM193A Affinity Capture-MS 28514442 9606 9606 BIOGRID
MDM4 PELI1 Affinity Capture-MS 28514442 9606 9606 BIOGRID
MDM4 CCNDBP1 Affinity Capture-MS 28514442 9606 9606 BIOGRID
MDM4 ASRGL1 Affinity Capture-MS 28514442 9606 9606 BIOGRID
MDM4 TP73 Affinity Capture-MS 28514442 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-MS 28514442 9606 9606 BIOGRID
MDM4 YWHAZ Affinity Capture-MS 28514442 9606 9606 BIOGRID
MDM4 EIF2AK4 Affinity Capture-MS 28514442 9606 9606 BIOGRID
MDM4 HBB Affinity Capture-MS 28514442 9606 9606 BIOGRID
MDM4 CDK1 Affinity Capture-Western 15735705 9606 9606 BIOGRID
MDM4 MDM2 Reconstituted Complex 26720344 9606 9606 BIOGRID
MDM4 TP53 Protein-peptide 18316739 9606 9606 BIOGRID
MDM4 HIPK2 Affinity Capture-Western 25961923 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 25961923 9606 9606 BIOGRID
MDM4 TP53 Reconstituted Complex 29023092 9606 9606 BIOGRID
MDM4 MTOR Affinity Capture-Western 28270148 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 29262653 9606 9606 BIOGRID
MDM4 MDM2 Reconstituted Complex 29262653 9606 9606 BIOGRID
MDM4 TP53 Reconstituted Complex 10629057 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 10629057 9606 9606 BIOGRID
MDM4 TP73 Affinity Capture-MS 29523541 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-MS 29523541 9606 9606 BIOGRID
MDM4 PELI1 Affinity Capture-MS 29523541 9606 9606 BIOGRID
MDM4 CSNK1A1 Affinity Capture-MS 29523541 9606 9606 BIOGRID
MDM4 YWHAB Affinity Capture-MS 29523541 9606 9606 BIOGRID
MDM4 CSNK1A1L Affinity Capture-MS 29523541 9606 9606 BIOGRID
MDM4 YWHAE Affinity Capture-MS 29523541 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-MS 29523541 9606 9606 BIOGRID
MDM4 YWHAQ Affinity Capture-MS 29523541 9606 9606 BIOGRID
MDM4 YWHAG Affinity Capture-MS 29523541 9606 9606 BIOGRID
MDM4 YWHAH Affinity Capture-MS 29523541 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 29523541 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 29523541 9606 9606 BIOGRID
MDM4 PELI1 Affinity Capture-Western 29523541 9606 9606 BIOGRID
MDM4 CSNK1A1 Affinity Capture-Western 29523541 9606 9606 BIOGRID
MDM4 PELI1 Reconstituted Complex 29523541 9606 9606 BIOGRID
MDM4 PELI1 Co-localization 29523541 9606 9606 BIOGRID
MDM4 MDM2 Reconstituted Complex 29524278 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 22745160 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 22745160 9606 9606 BIOGRID
MDM4 ALB Affinity Capture-Western 24278348 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 30598450 9606 9606 BIOGRID
MDM4 CSNK1A1 Affinity Capture-Western 30598450 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 30598450 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 31024344 9606 9606 BIOGRID
MDM4 TP53 Reconstituted Complex 31066983 9606 9606 BIOGRID
MDM4 MDM2 FRET 28205554 9606 9606 BIOGRID
MDM4 CD44 FRET 28205554 9606 9606 BIOGRID
MDM4 CDK4 FRET 28205554 9606 9606 BIOGRID
MDM4 CDKN2A FRET 28205554 9606 9606 BIOGRID
MDM4 CDKN2B FRET 28205554 9606 9606 BIOGRID
MDM4 EPHA2 FRET 28205554 9606 9606 BIOGRID
MDM4 FGFR4 FRET 28205554 9606 9606 BIOGRID
MDM4 LATS2 FRET 28205554 9606 9606 BIOGRID
MDM4 USP7 Reconstituted Complex 31519875 9606 9606 BIOGRID
MDM4 MDM4 Affinity Capture-Western 32075226 9606 9606 BIOGRID
MDM4 MDM2 Affinity Capture-Western 32075226 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 31462704 9606 9606 BIOGRID
MDM4 CSNK1A1 Affinity Capture-Western 31462704 9606 9606 BIOGRID
MDM4 TOP2A Affinity Capture-Western 30672125 9606 9606 BIOGRID
MDM4 TP53 Affinity Capture-Western 30672125 9606 9606 BIOGRID
MDM4 TOP2A Co-fractionation 30672125 9606 9606 BIOGRID
 Annotation of MDM4
 TCGA cancer survival map of MDM4


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.
Reset Add The plot axis-x order will follow the list.


Calculate the hazards ratio based on Cox PH Model.
We use log2(TPM + 1) for log-scale.
All Add
Reset The plot is based on the datasets of list.


 Expression of  MDM4
 Disease information of  MDM4