TcoF overview
TcoF: SIRT2
GeneID: 10011
Name: NAD-dependent protein deacetylase sirtuin-2
Ensembl: ENSG00000068903
Species: Human
Class: class HC
Family: Sirtuin
Disease: 2
Go term: 95
Pathway: 2
Hallmark: 4
Super Enhancer:

chr19:39373553-39390531 chr19:39375244-39391457 chr19:39375502-39391117 chr19:39373660-39391166

Enhancer:

chr19:39034300-39034410 chr19:39209160-39211560 chr19:39212330-39214250 chr19:39321810-39321940 chr19:39322160-39322360 chr19:38713350-38714750 chr19:38729620-38730110 chr19:38798390-38799430 chr19:38799700-38799860 chr19:38799970-38800040 chr19:38826520-38827860 chr19:38835010-38837080 chr19:38847500-38848910 chr19:38849200-38850100 chr19:38850220-38851120 chr19:38851480-38852280 chr19:38852500-38852840 chr19:38852910-38853010 chr19:38853220-38853350 chr19:38865600-38866790 chr19:38870050-38871530 chr19:38875170-38875840 chr19:38883670-38885000 chr19:38893860-38893970 chr19:38907810-38909030 chr19:38909200-38910260 chr19:38931500-38932980 chr19:38933090-38934190 chr19:38974160-38976220 chr19:38988540-38989660 chr19:38993370-38993510 chr19:38997190-38997460 chr19:38997590-38998350 chr19:38998470-38998730 chr19:39003350-39005660 chr19:39005750-39006720 chr19:39071140-39071550 chr19:39078460-39079810 chr19:39086640-39086950 chr19:39093100-39094180 chr19:39121070-39123060 chr19:39125760-39127520 chr19:39196770-39198750 chr19:39216540-39217590 chr19:39218670-39219630 chr19:39224420-39224780 chr19:39224840-39224950 chr19:39225030-39225450 chr19:39225510-39226000 chr19:39226070-39226140 chr19:39226180-39226740 chr19:39226960-39227190 chr19:39227200-39227790 chr19:39259660-39261600 chr19:39328120-39328230 chr19:39328290-39329030 chr19:39329660-39330730 chr19:39338080-39340340 chr19:39360340-39360580 chr19:39397060-39397860 chr19:39397950-39398030 chr19:39399970-39401200 chr19:39401720-39402200 chr19:39402290-39402450 chr19:39402490-39402730 chr19:39407800-39408360 chr19:39408470-39408560 chr19:39408650-39408730 chr19:39408770-39409060 chr19:39409170-39409400 chr19:39409450-39410400 chr19:39410510-39410720 chr19:39410790-39412030 chr19:39412090-39412160 chr19:39412310-39412640 chr19:39412720-39412870 chr19:39433390-39435600 chr19:39519700-39521660 chr19:39521760-39521840 chr19:39521960-39522500 chr19:39528200-39529440 chr19:39531360-39533440 chr19:39554790-39555770 chr19:39561080-39562240 chr19:39891200-39892480 chr19:39897570-39898380 chr19:39905320-39905630 chr19:39909640-39910520 chr19:39924400-39926240 chr19:39926350-39926480 chr19:39961160-39961990 chr19:39971600-39972520 chr19:39996090-39997670 chr19:39998260-39998460 chr19:38845490-38847120 chr19:38993610-38994110 chr19:39123320-39125630 chr19:39221860-39224340 chr19:39435740-39437110 chr19:39944160-39945780 chr19:39960040-39960750 chr19:38796150-38797550 chr19:39329240-39329530 chr19:39087130-39087670 chr19:39191360-39191640 chr19:39221660-39221740 chr19:38778580-38779770 chr19:38853470-38855530 chr19:38894130-38894190 chr19:38894340-38895540 chr19:38914500-38916700 chr19:39056410-39056810 chr19:39228030-39228110 chr19:39228280-39228780 chr19:39281530-39282210 chr19:39334740-39336280 chr19:39359810-39359880 chr19:39360050-39360210 chr19:39360900-39361200 chr19:39367420-39368870 chr19:39440100-39440610 chr19:38828140-38828230 chr19:39037750-39038870 chr19:39825950-39826070 chr19:39840930-39842450 chr19:39886840-39888090 chr19:39362510-39364520 chr19:38692640-38694760 chr19:38949980-38951010 chr19:38961480-38962760 chr19:39061330-39062060 chr19:39082900-39083920 chr19:39258250-39258780 chr19:39336730-39337950 chr19:39474150-39474690 chr19:39379800-39380320 chr19:39027990-39028510 chr19:39053710-39053870 chr19:39198840-39200030 chr19:39200120-39200890 chr19:39221520-39221600 chr19:39295880-39296500 chr19:39297240-39297400 chr19:39327500-39328020 chr19:38742090-38742940 chr19:38885430-38886110 chr19:39297500-39299190 chr19:39301610-39303070 chr19:39530320-39530870 chr19:39586940-39587780 chr19:38742970-38743530 chr19:38781210-38782470 chr19:38755640-38757080 chr19:38757100-38759580 chr19:38760490-38762000 chr19:39151190-39152380 chr19:39152500-39153620 chr19:39551440-39553320 chr19:39159200-39161350 chr19:39319460-39321710 chr19:39041650-39042720 chr19:39045030-39046420 chr19:39049390-39051360 chr19:39073080-39075580 chr19:39354830-39357110 chr19:39046810-39048650 chr19:38585690-38587050 chr19:38595750-38597170 chr19:38632080-38633210 chr19:38653010-38655110 chr19:38682950-38684170 chr19:38702770-38702910 chr19:38704400-38706770 chr19:38719890-38720190 chr19:38885120-38885280 chr19:38942530-38943450 chr19:38949520-38949780 chr19:38952150-38952940 chr19:38976840-38976980 chr19:39083980-39084950 chr19:39195660-39196680 chr19:39522890-39523140 chr19:38911840-38912600 chr19:38943660-38945870 chr19:38985270-38986180 chr19:39086370-39086570 chr19:38866870-38866990 chr19:39217740-39218580 chr19:39331020-39331120 chr19:39334560-39334640 chr19:39440980-39443210 chr19:39471450-39473220 chr19:39164820-39165290 chr19:39650220-39652640 chr19:39660450-39661840 chr19:39833220-39835380 chr19:39464280-39466220 chr19:38740150-38741870 chr19:38743620-38745600 chr19:38745690-38746770 chr19:38780100-38780750 chr19:38783260-38784970 chr19:38811610-38813420 chr19:39289440-39290980 chr19:39482920-39484810 chr19:39575040-39575730 chr19:39602130-39604460 chr19:39656270-39656910 chr19:39656980-39658860 chr19:39658950-39659260 chr19:39852890-39855180 chr19:39939630-39940360 chr19:39972670-39973090 chr19:39989680-39989830 chr19:40006660-40007830 chr19:39862090-39864480 chr19:39843020-39844640 chr19:38780920-38781170 chr19:38431130-38433150 chr19:38433180-38435620 chr19:38456340-38458420 chr19:38470200-38472040 chr19:38472080-38474530 chr19:38481840-38483080 chr19:38496610-38497710 chr19:38505950-38508070 chr19:38569660-38571890 chr19:38640300-38640760 chr19:38663570-38665320 chr19:38684420-38685150 chr19:38685200-38686970 chr19:38765160-38765790 chr19:38766790-38767000 chr19:38772140-38773810 chr19:38773980-38774260 chr19:38774650-38777030 chr19:38778120-38778510 chr19:38800280-38800540 chr19:38802750-38804880 chr19:38805200-38805480 chr19:38851290-38851370 chr19:38900740-38901520 chr19:39161420-39163100 chr19:39163700-39163850 chr19:39207960-39208560 chr19:39214720-39214790 chr19:39215410-39216360 chr19:39229290-39230690 chr19:39230860-39231210 chr19:39246870-39249260 chr19:39249740-39250980 chr19:39253150-39255390 chr19:39299300-39299380 chr19:39299590-39299790 chr19:39303160-39303480 chr19:39309340-39311780 chr19:39314240-39315770 chr19:39336380-39336490 chr19:39485980-39487240 chr19:39536200-39537740 chr19:39620310-39622800 chr19:39623070-39625180 chr19:39637200-39638390 chr19:39640380-39641290 chr19:39641420-39642200 chr19:39642770-39643680 chr19:39644750-39646220 chr19:39649570-39650050 chr19:39659480-39660170 chr19:39727690-39729680 chr19:39924060-39924160 chr19:39924200-39924300 chr19:40009620-40009710 chr19:40009810-40010780 chr19:38419110-38420680 chr19:38467860-38469890 chr19:38682220-38682780 chr19:38763690-38764960 chr19:39205200-39207280 chr19:38898220-38899390 chr19:38939620-38940660 chr19:38996040-38996440 chr19:39688890-39689800 chr19:39689910-39690980 chr19:38902020-38903310 chr19:38903460-38903570 chr19:38903690-38903830 chr19:38903940-38904030 chr19:38997020-38997110 chr19:39018420-39018940 chr19:39034080-39034170 chr19:39087780-39087960 chr19:39088020-39088120 chr19:39099320-39100230 chr19:39240710-39241780 chr19:39271170-39272200 chr19:39395500-39395650 chr19:39070440-39070580 chr19:39384170-39384450 chr19:38856660-38857790 chr19:39671270-39673310 chr19:39673690-39674630 chr19:39674830-39676410 chr19:39282400-39284740 chr19:39990110-39990230 chr19:39792360-39794780 chr19:38872870-38873890 chr19:38987600-38988250 chr19:39291750-39292310 chr19:38941540-38942400 chr19:39066430-39066550 chr19:39066600-39068550 chr19:39380390-39380490 chr19:39653360-39654230 chr19:39655420-39655710

Promoter:

chr19:39369195-39390502

 ChIP-seq based regulatory details of SIRT2
Sample ID Experiment target Biosample type Biosample term name GSM ID Tissue type Source
 Downstream target genes of SIRT2
 Protein-protein interaction of SIRT2
OFFICIAL_SYMBOL_A OFFICIAL_SYMBOL_B EXPERIMENTAL_SYSTEM PUBMED_ID ORGANISM_A_ID ORGANISM_B_ID SOURCE
SIRT2 PHB2 Affinity Capture-MS 17353931 9606 9606 BIOGRID
SIRT2 GYS1 Affinity Capture-MS 17353931 9606 9606 BIOGRID
SIRT2 RTN4 Affinity Capture-MS 17353931 9606 9606 BIOGRID
SIRT2 KRT78 Affinity Capture-MS 17353931 9606 9606 BIOGRID
SIRT2 SARS Affinity Capture-MS 17353931 9606 9606 BIOGRID
SIRT2 DNAJB8 Affinity Capture-Western 20159555 9606 9606 BIOGRID
SIRT2 DNAJB6 Affinity Capture-Western 20159555 9606 9606 BIOGRID
SIRT2 HIST1H3A Biochemical Activity 19801601 9606 9606 BIOGRID
SIRT2 EP300 Biochemical Activity 18995842 9606 9606 BIOGRID
SIRT2 EP300 Affinity Capture-Western 18722353 9606 9606 BIOGRID
SIRT2 ING1 Affinity Capture-Western 14522900 9606 9606 BIOGRID
SIRT2 FOXO1 Biochemical Activity 15220471 9606 9606 BIOGRID
SIRT2 RUNX3 Affinity Capture-Western 21511279 9606 9606 BIOGRID
SIRT2 FZR1 Biochemical Activity 22014574 9606 9606 BIOGRID
SIRT2 CDC20 Biochemical Activity 22014574 9606 9606 BIOGRID
SIRT2 FOXO1 Affinity Capture-Western 24419059 9606 9606 BIOGRID
SIRT2 EP300 Biochemical Activity 23934153 9606 9606 BIOGRID
SIRT2 HIST1H3A Biochemical Activity 19270680 9606 9606 BIOGRID
SIRT2 RAB3GAP2 Affinity Capture-MS 26186194 9606 9606 BIOGRID
SIRT2 GPAM Affinity Capture-MS 26186194 9606 9606 BIOGRID
SIRT2 RAB3GAP1 Affinity Capture-MS 26186194 9606 9606 BIOGRID
SIRT2 SCFD2 Affinity Capture-MS 26186194 9606 9606 BIOGRID
SIRT2 SARS Affinity Capture-MS 26186194 9606 9606 BIOGRID
SIRT2 FADS1 Affinity Capture-MS 26186194 9606 9606 BIOGRID
SIRT2 MTDH Affinity Capture-MS 26186194 9606 9606 BIOGRID
SIRT2 DEGS1 Affinity Capture-MS 26186194 9606 9606 BIOGRID
SIRT2 ORC2 Affinity Capture-MS 26186194 9606 9606 BIOGRID
SIRT2 TRAPPC12 Affinity Capture-MS 26186194 9606 9606 BIOGRID
SIRT2 VAMP7 Affinity Capture-MS 26186194 9606 9606 BIOGRID
SIRT2 TUBA4A Biochemical Activity 12620231 9606 9606 BIOGRID
SIRT2 SKP2 Affinity Capture-Western 26942878 9606 9606 BIOGRID
SIRT2 MDM2 Biochemical Activity 28196907 9606 9606 BIOGRID
SIRT2 PLA2G4A Affinity Capture-Western 26303530 9606 9606 BIOGRID
SIRT2 PLA2G4A Reconstituted Complex 26303530 9606 9606 BIOGRID
SIRT2 SARS Affinity Capture-MS 28514442 9606 9606 BIOGRID
SIRT2 SCFD2 Affinity Capture-MS 28514442 9606 9606 BIOGRID
SIRT2 RAB3GAP1 Affinity Capture-MS 28514442 9606 9606 BIOGRID
SIRT2 GPAM Affinity Capture-MS 28514442 9606 9606 BIOGRID
SIRT2 ORC2 Affinity Capture-MS 28514442 9606 9606 BIOGRID
SIRT2 MTDH Affinity Capture-MS 28514442 9606 9606 BIOGRID
SIRT2 FADS1 Affinity Capture-MS 28514442 9606 9606 BIOGRID
SIRT2 RAB3GAP2 Affinity Capture-MS 28514442 9606 9606 BIOGRID
SIRT2 DEGS1 Affinity Capture-MS 28514442 9606 9606 BIOGRID
SIRT2 VAMP7 Affinity Capture-MS 28514442 9606 9606 BIOGRID
SIRT2 ARHGDIA Biochemical Activity 26719334 9606 9606 BIOGRID
SIRT2 SPOP Affinity Capture-Western 28073696 9606 9606 BIOGRID
SIRT2 HIF1A Affinity Capture-Western 24681946 9606 9606 BIOGRID
SIRT2 KAT2B Affinity Capture-Western 30482390 9606 9606 BIOGRID
SIRT2 SYVN1 Affinity Capture-Western 31932479 9606 9606 BIOGRID
SIRT2 GART Affinity Capture-MS 24981860 9606 9606 BIOGRID
SIRT2 tat Biochemical Activity 15719057 9606 11676 BIOGRID
SIRT2 tat Affinity Capture-Western 15719057 9606 11676 BIOGRID
 Annotation of SIRT2
 TCGA cancer survival map of SIRT2


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.
Reset Add The plot axis-x order will follow the list.


Calculate the hazards ratio based on Cox PH Model.
We use log2(TPM + 1) for log-scale.
All Add
Reset The plot is based on the datasets of list.


 Disease information of  SIRT2